Cell Immunity in Implant-Associated Infections Caused by Biofilm-Forming Microorganisms

Babushkina, I. V.; Mamonova, I. A.; Bondarenko, Alexander S.; Ulyanov, Vladimir Yu.; Норкин, И. А.

doi:10.1007/s10517-021-05087-6

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…I mplant-associated infection ranges with the most severe complications of larger joint replacements. Periprosthetic infection is often difficult to diagnose, its pathogenesis is underlain by the microorganism ability to form microbe biofilms on the surface of the implanted joints hindering the isolation of the agent from specimens for examination [1]. 5 to 34 percent of patients with periprosthetic infection receive false-negative results to their bacteriological tests.…”

Section: Introductionmentioning

confidence: 99%

Immunity status in patients with periprosthetic knee joint infection

Mamonova¹,

Babushkina²,

Bondarenko

et al. 2021

Preprint

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Mamonova I.A., Babushkina I.V., Bondarenko A.S., Ulyanov V.Yu. Immunity status in patients with periprosthetic knee joint infection. Implant-associated infection is one of the most severe complications after total replacement of larger joints. The diagnosis of periprosthetic infection is often impeded as 5-34% of bacteriological tests are false-negative. Now the investigations of the immune status of patients suspected of periprosthetic infection are considered perspective as these are aimed at finding the most significant indicators for underlying the diagnosis of this pathology. In this research, we assessed immunology indicators in peripheral blood of patients with periprosthetic infection in their knee joints. We determined immunology characteristics associated with the clinical aspects of the progressing pathology. Our findings can be used as the basis for further search of pathophysiological mechanisms of periprosthetic infection progress in the knee joint as well as defining new diagnostic approaches.

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Section: Introductionmentioning

confidence: 99%

Immunity status in patients with periprosthetic knee joint infection

Mamonova¹,

Babushkina²,

Bondarenko

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…The chronic inflammation caused by the response of the body’s immune system to the implant wear particles is believed to be the main reason for the implant aseptic loosening [5] while the septic inflammation is often induced by the chronic infection in the implantation area [1]. However, some studies claim that the diagnosis of periprosthetic inflammation is hindered with microbe biofilm formed by the pathogens; this results in making incorrect diagnoses leading to the wrong treatment strategy [2, 4]. Therefore, the investigation of mechanisms of aseptic inflammation progressing aimed at identifying pathogenic indicators of significant diagnostic value is a challenging line of research.…”

mentioning

confidence: 99%

Evaluation of systemic immune response in patients with inflammatory complications of large joint replacements

Mamonova

Babushkina

Ulyanov

et al. 2022

Preprint

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We studied the features of systemic immunity in patients with inflammatory complications of their knee replacements and used the factor analysis to find immune characteristics associated with the progress of the pathological condition. The components indicative of changes related to the development of cell and humoral immune response in patients were isolated. Our findings present prospects for the development of new diagnostic techniques ensuring higher precision in searching for adequate surgical methods.

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Assessment of the Systemic Immune Response in Patients With Inflammatory Complications of Large Joint Implants

Mamonova

Babushkina

Ulyanov

et al. 2023

RCLD

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One of the most common reasons for the progressing of aseptic instability of implanted structures in patients with end-stage osteoarthrosis is a disorder of immunogenulatory processes of bone tissue remodeling along with chronic inflammatory response influenced by endoprosthesis wear components. This research features the specifics of systemic immune response in patients with inflammatory complications in late postoperative period after total replacements of large joints. The factor analysis enabled determining the most significant immunological mechanisms associated with the progressing of implant aseptic instability. Pathogenetically significant components involved in the formation of cellular and humoral immune responses in patients with signs of inflammatory activity in late postoperative period have been identified. Our findings can be used in designing diagnostic and prognostic criteria for systemic inflammatory response severity in preoperative monitoring of the condition of patients in need of large joint arthroplasties, and also in detecting the progress of implant aseptic instability.

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Cell Immunity in Implant-Associated Infections Caused by Biofilm-Forming Microorganisms

Cited by 3 publications

References 4 publications

Immunity status in patients with periprosthetic knee joint infection

Immunity status in patients with periprosthetic knee joint infection

Evaluation of systemic immune response in patients with inflammatory complications of large joint replacements

Assessment of the Systemic Immune Response in Patients With Inflammatory Complications of Large Joint Implants

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