Immunity status in patients with periprosthetic knee joint infection

Abstract

Mamonova I.A., Babushkina I.V., Bondarenko A.S., Ulyanov V.Yu. Immunity status in patients with periprosthetic knee joint infection. Implant-associated infection is one of the most severe complications after total replacement of larger joints. The diagnosis of periprosthetic infection is often impeded as 5-34% of bacteriological tests are false-negative. Now the investigations of the immune status of patients suspected of periprosthetic infection are considered perspective as these are aimed at finding the most significant indicators for underlying the diagnosis of this pathology. In this research, we assessed immunology indicators in peripheral blood of patients with periprosthetic infection in their knee joints. We determined immunology characteristics associated with the clinical aspects of the progressing pathology. Our findings can be used as the basis for further search of pathophysiological mechanisms of periprosthetic infection progress in the knee joint as well as defining new diagnostic approaches.