“…However, the process of regeneration of the corneal endothelium in rabbits differs from that in mammals that are phylogenetically higher, including humans [6, 10,19,22,23,26,32,35,36,39]. In order to determine the effect of corticosteroids in animals whose corneal endothelium does not regenerate spontaneously by cell division, the present experiments were performed on cats, in which, as in humans, corneal re-endothelialization occurs mostly through cell enlargement and not through mitosis [20]. Following identical trauma to the In a previous study, which correlated the functional ability and the morphology of regenerating feline corneal endothelial cells, we demonstrated that the appearance of large numbers of giant (3000-4000 btm a) nonhexagonal cells induced decompensation of the dehydrating function of the endothelium [19].…”