Cell cycle regulator in primary lung adenocarcinoma and its haematogenous metastases

Refractory remodeling of the microenvironment by abnormal type V collagen, apoptosis, and immune response in non-small cell lung cancer

“…There is therefore great interest in finding ways to identify which tumors are likely to invade and metastasize, thereby shortening the patient's life, and to optimize therapeutic efforts for each individual patient. In this regard, our group has been studying morphometric and biological markers in resected lung cancer and its correspondent lymphatic and hematogenous metastasis [12][13][14][15][16][17][18][19][20]. Lung cancer is the phenotypic consequence of the interactions between cellular and microenvironment factors, such as blood supply and ECM, in terms of growth, invasion, and metastasis, and currently much interest is focused on the influence of these factors on programmed cell death, or apoptosis.…”

Different morphology, stage and treatment affect immune cell infiltration and long‐term outcome in patients with non‐small‐cell lung carcinoma

“…This could facilitate optimization of therapeutic efforts for each patient. In this regard, our group have studied morphometric and biological markers in resected lung cancers and in associated lymphatic and haematogenous metastases 2–11 . With regard to growth, invasion and metastasis, lung cancer is the phenotypic consequence of the interaction between factors in the tumour environment and in surrounding non‐tumoral tissue.…”

“…In this regard, our group have studied morphometric and biological markers in resected lung cancers and in associated lymphatic and haematogenous metastases. [2][3][4][5][6][7][8][9][10][11] With regard to growth, invasion and metastasis, lung cancer is the phenotypic consequence of the interaction between factors in the tumour environment and in surrounding non-tumoral tissue. Currently, much interest is focused on the influence of these factors on the host immune response.…”

Papel da imuno-histoquímica no diagnóstico do câncer de pulmão

“…It has been observed that HER2 is produced in conjunction with EGFR in many lung adenocarcinomas. One group of authors (13) recently demonstrated that survival is strongly associated with cyclin D1, c-erbB-2 and VEGF expression in resected primary adenocarcinomas and their metastases.…”

“…(20) There have been various studies showing the relationship between high VEGF levels and poor prognosis in cases of NSCLC. (13,20) One group of authors (21) recently demonstrated the importance of VEGF as a prognostic marker in adenocarcinomas and their hematogenous metastases.…”