Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells

Okamura, Daiji; Maeda, Ikuma; Taniguchi, Hirofumi; Tokitake, Yuko; Ikeda, Makiko; Ozato, Keiko; Mise, Nathan; Abe, Kuniya; Noce, Toshiaki; Belmonte, Juan Carlos Izpisúa; Matsui, Yasuhisa

doi:10.1101/gad.202242.112

Cited by 26 publications

(17 citation statements)

References 34 publications

(35 reference statements)

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“…In particular, the significant SNP in the vicinity of the 7SK gene on BTA10 relates to small RNA that are important for the regulation of transcription. Our significant result stays in line with experimental findings by Okamura et al (2012), who demonstrated a role of small RNA in the proliferation of germ cells in mouse embryos. The gene PAPPA on BTA8, with a significant effect on the number of spermatozoa estimated for rs109336730 located within an intron of this gene, codes for a pregnancy-associated plasma protein A and is thus related to female fertility.…”

Section: Discussionsupporting

confidence: 95%

Genome-wide association study for semen production traits in Holstein-Friesian bulls

Suchocki

Szyda

2015

Journal of Dairy Science

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Identifying genomic regions, particularly individual genes associated with semen quality traits, may be very important for improving sire fertility via selective breeding. The aim of the study was to estimate (co)variance components and effects of single nucleotide polymorphisms (SNP) from the Illumina BovineSNP50 BeadChip (Illumina, San Diego, CA) on semen production traits and to find candidate genes for these traits. The analyzed data set originates from the Polish Holstein-Friesian dairy cattle population and consists of 1,212 bulls kept at 4 artificial insemination stations. For each bull, 5 semen production traits were collected: sperm concentration, semen volume, number of spermatozoa, motility, and motility score. A multitrait mixed model was used to estimate genetic parameters. The parameters obtained were used to estimate SNP effects for each trait separately by the mixed model, which is used in the Polish direct genomic value project. Additionally, genes located in the vicinity of significant SNP were selected as candidate genes. For motility, 20 genome-wide significant SNP, located on 12 autosomes, were identified. For sperm concentration, we found 7 significant SNP: 3 on chromosome X, and 1 on chromosomes 1, 6, 23, and 24. For semen volume and motility score, 3 and 1 significant SNP were detected, respectively. All these SNP were located on chromosome X. For the number of spermatozoa, 12 significant SNP were observed. Six SNP were located on chromosome X, 3 on chromosome 8, and 1 on chromosomes 2, 7, and 16. This study clearly indicated a key role of the X chromosome in the determination of semen quality and emphasized that including such traits into genetic evaluation should be strongly considered.

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Section: Discussionsupporting

confidence: 95%

Genome-wide association study for semen production traits in Holstein-Friesian bulls

Suchocki

Szyda

2015

Journal of Dairy Science

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“…LncRNAs which are generated in intronic, intergenic, antisense loci or overlapping regions play a great role in diverse gene regulatory functions (37,38). At present, numerous studies have demonstrated that lncRNAs are involved in tumor carcinogenesis since it can accelerate cell proliferation through controlling correlative proteins (39)(40)(41). In the present study, we found that the expression levels of lncRNA-SNHG7 mRNA and protein obviously increased in lung cancer tissues compared to adjacent non-cancerous tissues.…”

Section: Discussionsupporting

confidence: 50%

lncRNA-SNHG7 promotes the proliferation, migration and invasion and inhibits apoptosis of lung cancer cells by enhancing the FAIM2 expression

et al. 2016

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There is growing evidence that long non-coding RNAs (lncRNAs) are related to cancer development. In the present study, we found that the expression levels of lncRNA-SNHG7 mRNA and protein obviously increased in lung cancer tissues compared to adjacent non-cancerous tissues. Simultaneously, the expression levels of Fas apoptotic inhibitory molecule 2 (FAIM2) also increased in lung cancer tissues. In addition, lncRNA-SNHG7 was of positive relevance with FAIM2 in human lung cancer tissues. Silence of lncRNA‑SNHG7 by siRNA repressed the level of FAIM2 protein and suppressed cell proliferation, migration and invasion and accelerated apoptosis of A594 cells in vitro. Furthermore, silence of FAIM2 by siRNA generated a phenotype similar to silence of lncRNA-SNHG7 by siRNA. Therefore, our research showed that lncRNA-SNHG7 promotes the proliferation, migration and invasion, and inhibits apoptosis of lung cancer cells by enhancing the FAIM2 expression, suggesting that lncRNA-SNHG7 as a key regulator of gene expression, may be a promising therapeutic strategy for the treatment of lung cancer. It may improve the understanding of their biogenesis and function of lung cancer and further provide the theoretical fundamental basis for cancer pathogenesis and treatment.

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“…Previous studies have found associations of the 7SK variants with traits related to fertility and sexual precocity in bull and cattle, respectively (Melo et al, ; Suchocki & Szyda, ). Also, it has been demonstrated that this candidate gene has an important role on the control of primordial germ cell proliferation of mouse embryos (Okamura et al, ). SMG9 is another candidate gene in this selection region on ECA10.…”

Section: Discussionmentioning

confidence: 99%

Whole‐genome sequence analysis reveals candidate genomic footprints and genes associated with reproductive traits in Thoroughbred horse

Nanaei

Mehrgardi

Esmailizadeh

2020

Reprod Domestic Animals

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The primary objective of most horse breeding operations was to maximize reproductive efficiency and minimize the cost of producing live foals. Here, we compared individual horses from the Thoroughbred population (n = 17), known as a horse breed with poor reproductive performance, with other six horse populations (n = 28), to detect genomic signatures of positive selection underlying of reproductive traits. A number of protein‐coding genes with significant (p‐value <.01) higher FST values (616 genes) and a lower value for nucleotide diversity (π) (310 genes) were identified. The results of our study revealed some candidate genes such as IGFBP2, IGFBP5, GDF9, BRINP3 and GRID1 are possibly associated with functions influencing reproductive traits. These genes may have been under selection due to their essential roles in reproduction performance in horses. The candidate selected genes identified in this work should be of great interest for future research into genetic architecture of traits relevant to horse breeding programmes.

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Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells

Cited by 26 publications

References 34 publications

Genome-wide association study for semen production traits in Holstein-Friesian bulls

Genome-wide association study for semen production traits in Holstein-Friesian bulls

lncRNA-SNHG7 promotes the proliferation, migration and invasion and inhibits apoptosis of lung cancer cells by enhancing the FAIM2 expression

Whole‐genome sequence analysis reveals candidate genomic footprints and genes associated with reproductive traits in Thoroughbred horse

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