Cell culture on PCL/PLGA blends

Abstract

Bioresorbable polymers have been studied as support for cell culture in the tissue engineering area. Osteoblastic cells were cultivated on poly(e-caprolactone), poly(lactic acid-co-glycolic acid), and (70/30), (50/50), and (30/70) blends. Cytotoxicity and cell adhesion assays and scanning electronic microscopy studies were described. The cells presented significant growth on the blends, showing no cytotoxic response. Results indicated that these blends are promising as devices for bone tissue applications. V

Amphiphilic multiblock copolymers of PLLA, PEO and PPO blocks: Synthesis, properties and cell affinity

“…Osteoblast cells were obtained from a calvaria explants culture from three male 15-day-old Wistar rats, as described previously [25]. Briefly, the skin and soft connective tissues were removed.…”

Electrospun Biocomposite Polycaprolactone/Collagen Tubes as Scaffolds for Neural Stem Cell Differentiation

“…These biomimetic scaffolds can be reconstructed to provide physical and chemical cues that match the surrounding tissues, and provide support to the particular cell type required for specific tissue engineering applications [ 16 ]. In particular, poly(ε-caprolactone) (PCL) is a synthetic, biodegradable and biocompatible polymer, which has been investigated as a biomaterial for surgery and drug delivery systems [ 17 , 18 ], as there are no toxic effects from degradation products [ 19 , 20 ]. Furthermore, PCL is the most widely investigated synthetic polymer and has FDA approval in various devices for medical applications [ 21 ].…”

Biological Evaluation of PLDLA Polymer Synthesized as Construct on Bone Tissue Engineering Application

“…Osteoblasts were obtained from explants of calvarial from three Wistar rats as previously described 20,21 . Briefly, the skin, soft connective tissues and periosteum were removed and then, calvaria were dissected from 15 day old of three Wistar rats.…”