Cell Behavior on Polymer Surfaces with Different Functional Groups

Lee, Jin Ho; Lee, Jin Whan; Khang, Gilson; Lee, Hai Bang

doi:10.1007/978-1-4899-0112-5_45

Cited by 26 publications

(40 citation statements)

References 10 publications

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“…The whole process of adhesion and spreading of the cells after contact to biomaterials consists of cell attachment, growth of filopodia, cytoplasmic webbing and flattening of the cell mass, and the ruffling of peripheral cytoplasm, which progress in a sequential fashion. 3 The morphology of attached cells was examined using SEM. Figure 1(a-d) shows the morphology of fibroblasts cultured on the CO 2 laser-treated PET surface and unmodified PET after 48 h incubation in culture medium.…”

Section: Resultsmentioning

confidence: 99%

“…1 A large number of groups have studied the interaction of biomedical materials with cultured cells because cell compatible materials are thought to be very important in many biomedical applications. [2][3][4][5] The control of cell adhesion to synthetic polymers is also a key factor in tissue engineering, which rests on the ability to direct specific cell types to proliferate, migrate, and express physiological behaviors in order to support and stimulate cellular architecture and tissue reconstraction. [6][7][8] Numerous in vitro experiments have shown that the cell behavior is influenced by the physicochemical properties of polymer surfaces such as wettability, chemistry, charge, roughness and rigidity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cell behavior on laser surface-modified polyethylene terephthalatein vitro

Dadsetan

Mirzadeh

Sharifi-Sanjani

et al. 2001

J. Biomed. Mater. Res.

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This work has been undertaken to study the cell behavior of L929 fibroblasts on the laser irradiated polyethylene terephthalate (PET) surface. To modify the surface properties of the PET, CO2 pulsed laser at the wavelength of 9.25 microm and KrF excimer laser at 248 nm with various number of pulses were used. Laser irradiation caused some changes in the chemical and physical properties of the laser-treated film surfaces, which were evaluated using different techniques. These changes may affect the cell adhesion and growth on the laser-treated PET. Therefore, cell attachment and spreading were investigated on the laser-treated PET in vitro. The data from in vitro assays showed the fibroblast cells were attached and proliferated extensively on the CO2 and KrF laser-treated films in comparison with the unmodified PET. The results obtained from the cell behavior studies revealed that surface morphology and wettability affected cell adhesion and spreading on the laser-treated PET.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cell behavior on laser surface-modified polyethylene terephthalatein vitro

Dadsetan

Mirzadeh

Sharifi-Sanjani

et al. 2001

J. Biomed. Mater. Res.

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show abstract

“…A number of studies have shown that differences in cell adhesion are brought about by the introduction of functional groups having either different affinities for serum proteins or structural similarities to extracellular matrix components. [40][41][42][43] However, the branching modification introduced here apparently had no clearly observable effect on the medium-term (7 days) interactions of SMCs with chitosan.…”

Section: Discussionmentioning

confidence: 76%

Branched chitosans: Effects of branching parameters on rheological and mechanical properties

Aggarwal

Matthew

2007

J Biomedical Materials Res

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Chitosan continues to be studied as a promising biomaterial for tissue repair and regeneration applications. However, chitosan structures show a large reduction in tensile strength in the wet state. Methods for improving the wet strength of chitosan materials may broaden its applicability as a tissue scaffold for applications requiring significant load bearing capacity. In this study, the role of molecular architecture in defining the mechanical properties of hydrated chitosan membranes was examined. Specifically, branched chitosan molecules were synthesized with a range of branch lengths and branch densities. Physical and mechanical properties were characterized using viscometry, FTIR spectroscopy, and tensile testing measurements, and the results were correlated with the postulated architecture of the linear and branched chitosan materials. Both branch density and branch length were found to influence the mechanical properties of chitosan membranes. For example, high-molecular-weight (600 kDa) chitosans grafted with 80 kDa branches exhibited up to twofold increases in both tensile strength and extensibility. FTIR results indicated that these increases correlated with enhanced levels of hydrogen bonding in the branched materials. Vascular smooth muscle cells cultured on cast membranes of the branched chitosans exhibited no differences in adhesion or spreading as compared to the linear polymer. The results indicate that the mechanical properties of chitosan materials can be improved by the induction of a branched molecular architecture.

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“…Some studies have shown that cornea cells showed enhanced attachment and growth on plasma-treated surfaces vs. untreated surfaces, and exploration into whether this applies to other types of cells may have merit [48]. Studies prepared by Ho et al found that polymer samples that undergo water vapor plasma treatment may elicit enhanced cell attachment compared to untreated samples, potentially due to the formation of hydroxyl groups on the surface, allowing for hydrogen bond formation between the surface and the cells [81,82].…”

Section: Chemical Modification Of the Surfacementioning

confidence: 99%

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

Govindarajan

Shandas

2014

Polymers

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Abstract:The search for a single material with ideal surface properties and necessary mechanical properties is on-going, especially with regard to cardiovascular stent materials. Since the majority of stent problems arise from surface issues rather than bulk material deficiencies, surface optimization of a material that already contains the necessary bulk properties is an active area of research. Polymers can be surface-modified using a variety of methods to increase hemocompatibilty by reducing either late-stage restenosis or acute thrombogenicity, or both. These modification methods can be extended to shape memory polymers (SMPs), in an effort to make these materials more surface compatible, based on the application. This review focuses on the role of surface modification of materials, mainly polymers, to improve the hemocompatibility of stent materials; additional discussion of other materials commonly used in stents is also provided. Although shape memory polymers are not yet extensively used for stents, they offer numerous benefits that may make them good candidates for next-generation stents. Surface modification techniques discussed here include roughening, patterning, chemical modification, and surface modification for biomolecule and drug delivery.

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Cell Behavior on Polymer Surfaces with Different Functional Groups

Cited by 26 publications

References 10 publications

Cell behavior on laser surface-modified polyethylene terephthalatein vitro

Cell behavior on laser surface-modified polyethylene terephthalatein vitro

Branched chitosans: Effects of branching parameters on rheological and mechanical properties

A Survey of Surface Modification Techniques for Next-Generation Shape Memory Polymer Stent Devices

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