Cell attachment and spreading on metal implant materials

Schwartz, Jeffrey; Avaltroni, Michael J.; Danahy, Michael P.; Silverman, Brett M.; Hanson, Eric L.; Schwarzbauer, Jean E.; Midwood, Kim S.; Gawalt, Ellen S.

doi:10.1016/s0928-4931(02)00310-7

Cited by 110 publications

(102 citation statements)

References 21 publications

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“…The native oxide film on Ti contains very low amounts of hydroxyl groups and only about 15% of the surface O is related to OH groups. [1] However, when a film of aqueous phosphoric acid on air-oxidized titanium is heated, a layer of crystalline titanium (III) dihydrogen orthophosphate Ti(H 2 PO 4 ) 3 forms and appears to be strongly adhered to the surface. [2] A surface of this composition is then suitable for silanisation.…”

Section: Introductionmentioning

confidence: 99%

ARXPS and high energy XPS characterisation of titanium surfaces for medical implants

Sunding¹,

Jensen²,

Stenstad³

et al. 2008

Surface & Interface Analysis

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Section: Introductionmentioning

confidence: 99%

ARXPS and high energy XPS characterisation of titanium surfaces for medical implants

Sunding¹,

Jensen²,

Stenstad³

et al. 2008

Surface & Interface Analysis

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“…In addition, the Ti x O y H z fragments that were detected in ToF-SIMS negative secondary ion spectra (Table IV) are consistent with the presence of hydroxide groups on the titanium nitride surfaces, which are essential for surface silanization. 27,35,37 Siloxane-anchored thin films are known to interact strongly on a variety of surfaces 38,40 such as silicon oxide, 41-43 aluminum oxide, 44,45 glass, 43 and titanium oxides. 16,17,27 Therefore, siloxane chemistry was chosen to modify the titanium nitride surfaces.…”

Section: Resultsmentioning

confidence: 99%

“…1,[31][32][33][34] It was suggested that covalent bonding and self-assembly of phosphonate molecules onto the surface of titanium oxide is possible due to surface OH group regeneration via proton transfer from the phosphonic group to the surface oxygen. 35 However, in the case of titanium nitride surface, OH group regeneration only occurs when there is an oxygen atom close to the phosphonic hydrogen, whereas no such regeneration is possible if the next neighbor is nitrogen. Siloxane chemistry has been widely used to anchor polymers such as styrene, poly(ethylene glycol)acrylate, and poly(ethylene glycol)methacrylate onto titanium oxide surfaces through ATRP.…”

Section: Introductionmentioning

confidence: 99%

“…The driving force for this self-assembly is the in situ formation of polysiloxane with the Si-O bond connected either to another polysiloxane chain or to the surface. 35,37,38 The difference in covalent bonding and selfassembly between phosphonic acids and silanes makes the latter more suitable for tailoring the surface of titanium nitride. However, given the different reactivities of the titanium oxide and nitride surfaces, it is essential to carefully characterize the functionalization process on both surfaces.…”

Section: Introductionmentioning

confidence: 99%

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Grafting titanium nitride surfaces with sodium styrene sulfonate thin films

2014

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The importance of titanium nitride lies in its high hardness and its remarkable resistance to wear and corrosion, which has led to its use as a coating for the heads of hip prostheses, dental implants and dental surgery tools. However, the usefulness of titanium nitride coatings for biomedical applications could be significantly enhanced by modifying their surface with a bioactive polymer film. The main focus of the present work was to graft a bioactive poly(sodium styrene sulfonate) (pNaSS) thin film from titanium nitride surfaces via a two-step procedure: first modifying the surface with 3-methacryloxypropyltrimethoxysilane (MPS) and then grafting the pNaSS film from the MPS modified titanium through free radical polymerization. X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) were used after each step to characterize success and completeness of each reaction. The surface region of the titanium nitride prior to MPS functionalization and NaSS grafting contained a mixture of titanium nitride, oxynitride, oxide species as well as adventitious surface contaminants. After MPS functionalization, Si was detected by XPS, and characteristic MPS fragments were detected by ToF-SIMS. After NaSS grafting, Na and S were detected by XPS and characteristic NaSS fragments were detected by ToF-SIMS. The XPS determined thicknesses of the MPS and NaSS overlayers were $1.5 and $1.7 nm, respectively. The pNaSS film density was estimated by the toluidine blue colorimetric assay to be 260 6 70 ng/cm 2

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“…Parmi les différentes techniques de modification de surfaces répertoriées dans la littérature [2,3], l'utilisation de dérivés de catéchols sembleêtre celle présentant le plus fort potentiel, notamment en raison de ses fortes propriétés d'adhésion sur de nombreux supports [4]. La dopamine, une molécule commerciale dérivée des catéchols, possède une fonction amine primaire susceptible d'être modifiée chimiquement permettant d'apporter une fonctionnalité supplémentaire.…”

Section: Introductionunclassified

Elaboration de plateformes biomimétiques à base de dopamine pour la fonctionnalisation du titane

Laure

Zobrist

Lyskawa

et al. 2013

MATEC Web of Conferences

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Abstract. The aim of this study concerns the functionalization of titanium surfaces by using versatile dopamine based on biomimetic anchors. This general concept was exploited to design new biomaterials which might be used as medical implants. In this context, two different grafting strategies based onto the "grafting to" approach were developed. The first one consisted on the synthesis and the immobilization of well-defined catechol end-functionalized polymers onto titanium surfaces. The second strategy was based on the functionalization of titanium surfaces by using dopamine derivates containing, on the one hand, a catechol unit for surface attachment and, on the other hand, a furan or a maleimide moiety able to react, on demand, through reversible Diels Alder (DA) reaction.Résumé. L'étude concerne la fonctionnalisation de surfacesà base de titaneà partir d'une ancre chimique biomimétique modifiable chimiquement, la dopamine, dans le but de concevoir des biomatériaux utilisables en tant que dispositifs implantables.Deux approches différentes de greffage par la stratégie «graft to» sont proposées. La première consiste en la synthèse et l'immobilisation sur les surfaces de titane de polymères parfaitement définis et stimulables fonctionnalisés par un motif catéchol en extrémité de chaîne. La seconde propose de modifier préalablement la surface par une ancre chimique spécifique intégrant un motif catéchol d'une part et un motif furane ou maléimide d'autre part permettant d'engager sur demande une réaction réversible de cycloaddition de type Diels Alder (DA) avec une large gamme de molécules ou polymères fonctionnalisés par l'entité complémentaire.

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Cell attachment and spreading on metal implant materials

Cited by 110 publications

References 21 publications

ARXPS and high energy XPS characterisation of titanium surfaces for medical implants

ARXPS and high energy XPS characterisation of titanium surfaces for medical implants

Grafting titanium nitride surfaces with sodium styrene sulfonate thin films

Elaboration de plateformes biomimétiques à base de dopamine pour la fonctionnalisation du titane

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