Cell and tissue reactions to mineral trioxide aggregate and portland cement

Saidon, Jacob; He, Jianing; Zhu, Qiang; Safavi, Kamran E.; Spångberg, Larz S.W.

doi:10.1067/moe.2003.20

Cited by 247 publications

(237 citation statements)

References 15 publications

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“…1,6,8,[10][11][12]17 The factor responsible for the beneficial effects in MTA is also found in PC, 31 although it is important to emphasize that they are not identical materials. 13 This has resulted in a signifi cant body of research showing that PC appears to be a useful substitute for MTA.…”

Section: Discussionmentioning

confidence: 99%

“…13 This has resulted in a signifi cant body of research showing that PC appears to be a useful substitute for MTA. 17,21,24,27,31,32 However, only four studies reported the use of PC in conservative pulp therapy with considerable success in rats 24 and dogs. 16,17,23 To the best of our knowledge, this is the fi rst randomised controlled clinical trial assessing the effectiveness of PC in human primary teeth and comparing this regenerative dressing agent with MTA.…”

Section: Discussionmentioning

confidence: 99%

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Pulpotomy of human primary molars with MTA and Portland cement: a randomised controlled trial

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pulpotomy of human primary molars with MTA and Portland cement: a randomised controlled trial

et al. 2009

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“…It is interesting to evaluate the reaction of fibroblasts to the materials because those cells are involved with the healing process. The established L929 cell line used in this study is commonly employed in biocompatibility studies (10,(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

L929 cell response to root perforation repair cements: an in vitro cytotoxicity assay

Miranda¹,

Fidel

Boller

2009

Braz. Dent. J.

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This study compared the cytotoxicity of an experimental epoxy-resin and calcium hydroxide-based cement (MBPc), gray mineral trioxide aggregate (MTA) and white mineral trioxide aggregate (WMTA) using the agar overlay method with neutral red dye. L929 cells were seeded into 6-well culture plates where 48-h set test materials were placed on the agar overlay, in triplicate. Teflon and natural rubber served as negative and positive controls. After an incubation period of 24 h at 37ºC in a humidified atmosphere of 5% CO 2 in air, a discolored area around the samples and the positive controls could be observed and measured per quadrant. The mean values were compared and converted into grades to classify the results according to the table of cytotoxicity grades according to the Standard Operating Procedures (SOP) of the Oswaldo Cruz Foundation, Brazil. The nonviable cell areas and the morphological changes in the cells were observed with an inverted microscope. The results showed grade 1 (slight) for the two types of MTA (p>0.05) and grade 2 (mild) for the MBPc (p<0.001). All samples met the requirements of the test as none of the cultures showed reactivity higher than grade 2.

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“…5 Previous studies have shown that calcium silicate and MTA present similar chemical, physical and biological properties, [6][7][8] with the exception of radiopacity. [8][9][10] Calcium silicate does not have the minimum radiopacity recommended (3 mm equivalent of Al) by ISO 6876/2001 specifications. 11 Thus, a radiopacifier agent should be added in order to distinguish it from anatomical structures, in clinical conditions.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the color alteration and radiopacity promoted by bismuth oxide in calcium silicate cement

et al. 2013

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Analysis of the color alteration and radiopacity promoted by bismuth oxide in calcium silicate cement Abstract: The aim of the study was to determine if the increase in radiopacity provided by bismuth oxide is related to the color alteration of calcium silicate-based cement. Calcium silicate cement (CSC) was mixed with 0%, 15%, 20%, 30% and 50% of bismuth oxide (BO), determined by weight. Mineral trioxide aggregate (MTA) was the control group. The radiopacity test was performed according to ISO 6876/2001. The color was evaluated using the CIE system. The assessments were performed after 24 hours, 7 and 30 days of setting time, using a spectrophotometer to obtain the ∆E, ∆a, ∆b and ∆L values. The statistical analyses were performed using the Kruskal-Wallis/Dunn and ANOVA/ Tukey tests (p < 0.05). The cements in which bismuth oxide was added showed radiopacity corresponding to the ISO recommendations ( > 3 mm equivalent of Al). The MTA group was statistically similar to the CSC / 30% BO group (p > 0.05). In regard to color, the increase of bismuth oxide resulted in a decrease in the ∆E value of the calcium silicate cement. The CSC group presented statistically higher ∆E values than the CSC / 50% BO group (p < 0.05). The comparison between 24 hours and 7 days showed higher ∆E for the MTA group, with statistical differences for the CSC / 15% BO and CSC / 50% BO groups (p < 0.05). After 30 days, CSC showed statistically higher ∆E values than CSC / 30% BO and CSC / 50% BO (p < 0.05). In conclusion, the increase in radiopacity provided by bismuth oxide has no relation to the color alteration of calcium silicate-based cements.

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Cell and tissue reactions to mineral trioxide aggregate and portland cement

Cited by 247 publications

References 15 publications

Pulpotomy of human primary molars with MTA and Portland cement: a randomised controlled trial

Pulpotomy of human primary molars with MTA and Portland cement: a randomised controlled trial

L929 cell response to root perforation repair cements: an in vitro cytotoxicity assay

Analysis of the color alteration and radiopacity promoted by bismuth oxide in calcium silicate cement

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