Cell and Tissue Biology Paves a Path to Breast Cancer Prevention

Todhunter, Michael E.; LaBarge, Mark A.

doi:10.1016/j.trecan.2017.03.001

Cited by 4 publications

(3 citation statements)

References 15 publications

(14 reference statements)

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“…Overall, these chemoprevention cancer trials revealed that different sources of RA, rather than reducing the incidence of cancer, promoted both cancer growth and invasion [ 26 , 27 ]. Similar studies performed by the National Cancer Institute Breast and Prostate Cancer Cohort Consortium and the European Prospective Investigation of Cancer (EPIC) on subjects with different cancer predisposing conditions (e.g., obesity, diabetes, defective immunity, and aging) did not lead to firm conclusions [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ].…”

Section: Introductionmentioning

confidence: 93%

Emerging Cancer Epigenetic Mechanisms Regulated by All-Trans Retinoic Acid

Rossetti

Sacchi

2020

Cancers

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All-trans retinoic acid (RA), which is the dietary bioactive derivative obtained from animal (retinol) and plant sources (beta-carotene), is a physiological lipid signal of both embryonic and postembryonic development. During pregnancy, either RA deficiency or an excessive RA intake is teratogenic. Too low or too high RA affects not only prenatal, but also postnatal, developmental processes such as myelopoiesis and mammary gland morphogenesis. In this review, we mostly focus on emerging RA-regulated epigenetic mechanisms involving RA receptor alpha (RARA) and Annexin A8 (ANXA8), which is a member of the Annexin family, as well as ANXA8 regulatory microRNAs (miRNAs). The first cancer showing ANXA8 upregulation was reported in acute promyelocytic leukemia (APL), which induces the differentiation arrest of promyelocytes due to defective RA signaling caused by RARA fusion genes as the PML-RARA gene. Over the years, ANXA8 has also been found to be upregulated in other cancers, even in the absence of RARA fusion genes. Mechanistic studies on human mammary cells and mammary glands of mice showed that ANXA8 upregulation is caused by genetic mutations affecting RARA functions. Although not all of the underlying mechanisms of ANXA8 upregulation have been elucidated, the interdependence of RA-RARA and ANXA8 seems to play a relevant role in some normal and tumorigenic settings.

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Section: Introductionmentioning

confidence: 93%

Emerging Cancer Epigenetic Mechanisms Regulated by All-Trans Retinoic Acid

Rossetti

Sacchi

2020

Cancers

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“…The systems biology tools can demystify the mechanism of actions of different compounds by understanding the process affected by the drug. Gene expression profiles reported from drug resistant and drug sensitive cell lines to Lapatinib in breast cancer patients pointed to the loss of ErbB2, a plasma membrane bound receptor tyrosine kinase pathway for glucose metabolism through network-scoring method, Netwalk [ 27 , 28 , 29 ].…”

Section: Role Of Systems Biology In Drug Discovery and Developmentmentioning

confidence: 99%

The Role of Systems Biologic Approach in Cell Signaling and Drug Development Responses—A Mini Review

2018

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The immune system is an integral aspect of the human defense system and is primarily responsible for and involved in the communication between the immune cells. It also plays an important role in the protection of the organism from foreign invaders. Recent studies in the literature have described its role in the process of hematopoiesis, lymphocyte recruitment, T cell subset differentiation and inflammation. However, the specific molecular mechanisms underlying these observations remain elusive, impeding the elaborate manipulation of cytokine sequential delivery in tissue repair. Previously, the discovery of new drugs and systems biology went hand in hand; although Systems biology as a term has only originated in the last century. Various new chemicals were tested on the human body, and studied through observation. Animal models replaced humans for initial trials, but the interactions, response, dose and effect between animals and humans could not be directly correlated. Therefore, there is a need to form disease models outside of human subjects to check the effectiveness and response of the newer natural or synthetic chemicals. These emulate human disease conditions wherein the behavior of the chemicals would be similar in the disease model and humans.

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“…Thereafter, this novel technology was also adapted to generate organoid from human small intestine 4 . To date, efficient and robust protocols have been established for tissues covering colon 5 , liver 6 , pancreas 7 , brain 8 , breast 9 , prostate 10 , and ovaries 11 . Organoids have been developed to model multiple diseases, such as cystic fibrosis and Zika virus infection 12 , neurodevelopmental disorders 13 - 16 , and chronic liver diseases 17 .…”

Section: Introductionmentioning

confidence: 99%

Organoids in recapitulating tumorigenesis driven by risk factors: Current trends and future perspectives

Zhang¹,

Wang²,

Song³

et al. 2022

Int. J. Biol. Sci.

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Environmental and exogenous/ endogenous factors, in a setting of individual genetic predisposition, contribute to the cancer development. Over the years, epidemical evidence increasingly highlights the correlations of multiple cancer incentives and genetic alterations with cancer incidence. Unraveling the pivotal carcinogenesis events prompted by particular risk factors remarkably advances early surveillance and oncogenesis intervening. Traditional cell-based models and animal-based models are unrealistic and unreliable for translational study, respectively ascribing to the limited tumor heterogeneity and species-related variation. Organoid emerged as a fidelity model that well preserves the properties of its origin. With inherent quality of holistic perspective, organoid is therefore ideally suited for delineating the carcinogenesis under risk exposure, in favor of understanding pathogen-host interactions and alleviating cancer initiation. In this review, we have summarized the organoid model-based evidence that identified or validated carcinogenic risks, mainly including diet, aging, microbial infection, and chemical exposure. In addition, we envisioned the exciting prospect of organoid model in screening promising treatment and/or prevention during tumorigenesis. As a robust 3D in vitro system, organoid has been widespread applied in basial and clinical cancer research, which may elucidate crucial mechanisms of oncogenesis and develop novel targeting strategies.

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Cell and Tissue Biology Paves a Path to Breast Cancer Prevention

Cited by 4 publications

References 15 publications

Emerging Cancer Epigenetic Mechanisms Regulated by All-Trans Retinoic Acid

Emerging Cancer Epigenetic Mechanisms Regulated by All-Trans Retinoic Acid

The Role of Systems Biologic Approach in Cell Signaling and Drug Development Responses—A Mini Review

Organoids in recapitulating tumorigenesis driven by risk factors: Current trends and future perspectives

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