The Role of Systems Biologic Approach in Cell Signaling and Drug Development Responses—A Mini Review

Abstract

The immune system is an integral aspect of the human defense system and is primarily responsible for and involved in the communication between the immune cells. It also plays an important role in the protection of the organism from foreign invaders. Recent studies in the literature have described its role in the process of hematopoiesis, lymphocyte recruitment, T cell subset differentiation and inflammation. However, the specific molecular mechanisms underlying these observations remain elusive, impeding the elaborate manipulation of cytokine sequential delivery in tissue repair. Previously, the discovery of new drugs and systems biology went hand in hand; although Systems biology as a term has only originated in the last century. Various new chemicals were tested on the human body, and studied through observation. Animal models replaced humans for initial trials, but the interactions, response, dose and effect between animals and humans could not be directly correlated. Therefore, there is a need to form disease models outside of human subjects to check the effectiveness and response of the newer natural or synthetic chemicals. These emulate human disease conditions wherein the behavior of the chemicals would be similar in the disease model and humans.

Systems Biology Approaches to Understanding the Human Immune System

“…Thus, through these systems biologybased studies, novel pharmaceuticals (IDR-1018) and 2 existing drugs (Metformin and salubrinal) were identified as potential treatments for CF-related hyperinflammation. As such, along with numerous other studies [e.g., (89)(90)(91)(92)], it has been shown that integrating omics datasets using resources such as InnateDB and DrugBank can reveal potential drug targets for improved therapies.…”