Cell and Gene Therapy in Alzheimer's Disease

Glat, Micaela; Offen, Daniel

doi:10.1089/scd.2012.0633

Cited by 33 publications

(26 citation statements)

References 92 publications

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“…Several potential approaches for AD treatment such as cell and gene therapies are currently under investigation; however, a great number of compounds for AD failed to reach the goal [36].…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Hydrogen Sulfide against the Progression of Severe Alzheimer’s Disease in Transgenic Mice at Different Ages

et al. 2018

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Backgroud: Alzheimer disease is an age-related severe neurodegenerative pathology. The level of the third endogenous gas, hydrogen sulfide (H₂S), is decreased in the brain of Alzheimer’s disease (AD) patients compared with the brain of the age-matched normal individuals; also, plasma H₂S levels are negatively correlated with the severity of AD. Recently, we have demonstrated that systemic H₂S injections are neuroprotective in an early phase of preclinical AD. Objectives: This study focuses on the possible neuroprotection of a chronic treatment with an H₂S donor and sulfurous water (rich of H₂S) in a severe transgenic 3×Tg-AD mice model. Method: 3×Tg-AD mice at 2 different ages (6 and 12 months) were daily treated intraperitoneally with an H₂S donor and sulfurous water (rich of H₂S) for 3 months consecutively. We investigated the cognitive ability, brain morphological alterations, amyloid/tau cascade, excitotoxic, inflammatory and apoptotic responses. Results: Three months of treatments with H₂S significantly protected against impairment in learning and memory in a severe 3×Tg-AD mice model, at both ages studied, and reduced the size of Amyloid β plaques with preservation of the morphological picture. This neuroprotection appeared mainly in the cortex and hippocampus, associated with reduction in activity of c-jun N-terminal kinases, extracellular signal-regulated kinases and p38, which have an established role not only in the phosphorylation of tau protein but also in the inflammatory and excitotoxic response. Conclusion: Our findings indicate that appropriate treatments with various sources of H₂S, might represent an innovative approach to counteract early and severe AD progression in humans.

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“…Several potential approaches for AD treatment such as cell and gene therapies are currently under investigation; however, a great number of compounds for AD failed to reach the goal [36].…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Hydrogen Sulfide against the Progression of Severe Alzheimer’s Disease in Transgenic Mice at Different Ages

et al. 2018

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“…Conse-51 quences are progressive cognitive decline and behavioral abnormalities 52 (Giuliani et al, 2014a;Ittner and Götz, 2011;Sperling et al, 2013;Tayeb 53 et al, 2012). In addition to neuroprotective approaches for AD treat- Galimberti et al, 2013;Glat and Offen, 2013;Iqbal and Grundke-Iqbal, 58 2011; Lilja et al, 2013;Tayeb et al, 2012;Wang et al, 2010).…”

mentioning

confidence: 99%

NDP-α-MSH induces intense neurogenesis and cognitive recovery in Alzheimer transgenic mice through activation of melanocortin MC4 receptors

Giuliani

Neri

Canalini

et al. 2015

Molecular and Cellular Neuroscience

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“…Stem cells provide an opportunity for therapeutics to cure neurological disorders or injuries, such as Parkinson's and Alzheimer's diseases17181920. Parkinson's disease is resulted from the loss of dopaminergic neurons in the substantia nigra1821.…”

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confidence: 99%

“…Stem cells express glial-cell-line-derived neurotrophic factor, which has been shown to improve the survival and function of dopaminergic neurons that may be one approach to stop the death of dopaminergic neurons2022. Furthermore, stem cells can generate cholinergic neurons to improve the cognitive function of Alzheimer's disease patients1819.…”

mentioning

confidence: 99%

Labeling of neuronal differentiation and neuron cells with biocompatible fluorescent nanodiamonds

Hsu

Liu

Chang

et al. 2014

Sci Rep

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Nanodiamond is a promising carbon nanomaterial developed for biomedical applications. Here, we show fluorescent nanodiamond (FND) with the biocompatible properties that can be used for the labeling and tracking of neuronal differentiation and neuron cells derived from embryonal carcinoma stem (ECS) cells. The fluorescence intensities of FNDs were increased by treatment with FNDs in both the mouse P19 and human NT2/D1 ECS cells. FNDs were taken into ECS cells; however, FNDs did not alter the cellular morphology and growth ability. Moreover, FNDs did not change the protein expression of stem cell marker SSEA-1 of ECS cells. The neuronal differentiation of ECS cells could be induced by retinoic acid (RA). Interestingly, FNDs did not affect on the morphological alteration, cytotoxicity and apoptosis during the neuronal differentiation. Besides, FNDs did not alter the cell viability and the expression of neuron-specific marker β-III-tubulin in these differentiated neuron cells. The existence of FNDs in the neuron cells can be identified by confocal microscopy and flow cytometry. Together, FND is a biocompatible and readily detectable nanomaterial for the labeling and tracking of neuronal differentiation process and neuron cells from stem cells.

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Cell and Gene Therapy in Alzheimer's Disease

Cited by 33 publications

References 92 publications

Mechanisms of Hydrogen Sulfide against the Progression of Severe Alzheimer’s Disease in Transgenic Mice at Different Ages

Mechanisms of Hydrogen Sulfide against the Progression of Severe Alzheimer’s Disease in Transgenic Mice at Different Ages

NDP-α-MSH induces intense neurogenesis and cognitive recovery in Alzheimer transgenic mice through activation of melanocortin MC4 receptors

Labeling of neuronal differentiation and neuron cells with biocompatible fluorescent nanodiamonds

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