Celiac Disease Serology in Irritable Bowel Syndrome and Dyspepsia: A Population-Based Case-Control Study

Locke, G. Richard; Murray, Joseph A.; Zinsmeister, Alan R.; Melton, L. Joseph; Talley, Nicholas J.

doi:10.4065/79.4.476

Cited by 93 publications

(83 citation statements)

References 30 publications

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“…We therefore included data from the fully published paper (26), in lieu of the abstract data (58). There were another 4514 subjects identified in 14 studies (16,17,26,(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69) from the previous meta-analysis, of whom 2406 met diagnostic criteria for IBS. In total, therefore, the 36 studies recruited 15,256 individuals, of whom 9275 (60.8%) met diagnostic criteria for IBS.…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen of these studies were identified in the previous literature search (16,17,26,(59)(60)(61)(63)(64)(65)(66)(67)(68)(69), with the remaining 19 studies identified in the updated search (25, 37-42, 44-48, 50, 51, 53-57). The pooled prevalence of a positive EMA and/or tTG was 2.6% (95% CI 1.6% to 3.8%) ( Table 2), but with significant heterogeneity between studies (I 2 = 89.5%, P < 0.001).…”

Section: Yield Of Ema And/or Ttg Testing In Suspected Ibsmentioning

confidence: 99%

See 1 more Smart Citation

Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis

Irvine

Chey

Ford

2017

American Journal of Gastroenterology

132

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Section: Resultsmentioning

confidence: 99%

Section: Yield Of Ema And/or Ttg Testing In Suspected Ibsmentioning

confidence: 99%

Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis

Irvine

Chey

Ford

2017

American Journal of Gastroenterology

132

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“…The question whether dyspeptic patients have an increased risk of CD has been previously assessed, with conflicting results (2,4,7,13) . Some limitations must be mentioned: some of these studies were underpowered or did not use a pre-specified definition of dyspepsia.…”

Section: Discussionmentioning

confidence: 99%

“…Previous evidence trying to assess the risk of CD among dyspeptic patients has been inconclusive, showing in some cases notorious discrepancies (2,4,7,13) . This may be due to methodological differences in the way they were designed.…”

Section: Introductionmentioning

confidence: 99%

Celiac disease prevalence is not increased in patients with functional dyspepsia

Lasa¹,

Spallone²,

Gandara³

et al. 2017

Arq. Gastroenterol.

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-Background -Previous evidence trying to assess the risk of celiac disease among dyspeptic patients has been inconclusive, showing in some cases notorious discrepancies. Objective -To determine the prevalence of celiac disease in patients with dyspepsia compared to healthy controls without dyspepsia. Methods -Adult patients under evaluation for dyspepsia were invited to participate. These patients were offered an upper gastrointestinal endoscopy with duodenal biopsies. On the other hand, asymptomatic adult volunteers who performed a preventive visit to their primary care physician were invited to participate and agreed to undertake an upper gastrointestinal endoscopy with duodenal biopsies as well. Those patients with histologic signs of villous atrophy were furtherly evaluated and serological tests were performed in order to determine celiac disease diagnosis. Celiac disease prevalence was compared between groups. Results -Overall, 320 patients with dyspepsia and 320 healthy controls were recruited. There were no significant differences in terms of gender or age between groups. Celiac disease diagnosis was made in 1.25% (4/320) of patients in the dyspepsia group versus 0.62% (2/320) in the control group. Conclusion -Patients with dyspepsia who underwent routine duodenal biopsies did not show an increased risk for celiac disease when compared to healthy individuals. HEADINGS -Celiac disease. Dyspepsia. Endoscopy.

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“…Celiac disease is also associated with infertility, elevated liver enzymes, arthritis and various neurological manifestations (3,4,8). The diagnosis of celiac disease should be excluded in patients with irritable bowel syndrome (9). Conditions with an increased risk of developing celiac disease include Type I diabetes (3,(10)(11)(12)(13)(14), autoimmune thyroiditis (3,15), Down syndrome (3,(16)(17), Turner syndrome (3,18), Williams syndrome (19), selective IgA deficiency (3,20,21), and being a first or second degree relative of affected individuals (22,23) (Table 2).…”

Section: Clinical Manifestations Andmentioning

confidence: 99%

Practical considerations for the identification and follow-up of children with celiac disease

Dirks

2004

Paediatrics &Amp; Child Health

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Celiac disease is an immune-mediated enteropathy affecting 0.5% to 1% of children and is induced by dietary gluten in susceptible individuals carrying the human leukocyte antigen DQ2 or DQ8 heterodimer. If serological screening is positive or if a patient displays suggestive symptoms, an endoscopic biopsy of the distal duodenum is required to confirm the diagnosis. Symptoms of celiac disease are often mild or absent. Overt malabsorption occurs in only 2% to 10% of children. Individuals with a higher risk of developing celiac disease, including first-degree relatives of affected patients and children with type I diabetes, Turner syndrome, Williams syndrome or Down syndrome, should be offered screening for celiac disease along with a discussion of the implications. If serological testing is negative, a high index of suspicion should remain if malabsorption, iron deficiency or osteopenia is present. Also, immunoglobulin A deficiency should be excluded. At-risk individuals should undergo serial serological screening. Lifelong adherence to a gluten-free diet is the only treatment. If left untreated, symptomatic children with celiac disease carry an increased risk of developing osteoporosis and have a greater lifetime risk of cancer. The long-term outcome of undiagnosed or untreated asymptomatic individuals is less clear.Key Words: Celiac disease; Gluten-free diet; Gluten-sensitive enteropathy; IgA deficiency; Tissue transglutaminase; Type I diabetes Des considérations pratiques pour dépister et suivre les enfants atteints d'une maladie coeliaqueLa maladie coeliaque est une entéropathie d'origine immunologique qui touche de 0,5 % à 1,0 % des enfants et qui est induite par le gluten diététique chez des individus susceptibles porteurs de l'antigène HLA DQ2 ou DQ8 hétérodimère. Si le dépistage sérologique est positif ou si un patient présente des symptômes évocateurs, une biopsie endoscopique du duodénum distal s'impose pour confirmer le diagnostic. Les symptômes de maladie coeliaque sont souvent légers ou inexistants. Une malabsorption patente ne s'observe que chez 2 % à 10 % des enfants. Les individus plus vulnérables à la maladie coeliaque, y compris les parents au premier degré des patients atteints et les enfants souffrant

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Celiac Disease Serology in Irritable Bowel Syndrome and Dyspepsia: A Population-Based Case-Control Study

Cited by 93 publications

References 30 publications

Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis

Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis

Celiac disease prevalence is not increased in patients with functional dyspepsia

Practical considerations for the identification and follow-up of children with celiac disease

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