Celiac Disease in Association With Eosinophilic Esophagitis

Shah, Avani; McGreal, Nancy; Li, B.; Kagalwalla, Amir F.; Guandalini, Stefano

doi:10.1097/00005176-200610000-00062

Cited by 6 publications

(12 citation statements)

References 0 publications

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“…The coexistence of EoE and CD in the same patient has been reported firstly by Shah et al 9 in 2006. Although CD and EoE/EE are distinct disorders that have different clinicopathological findings, an association between these entities has been postulated in recent years 8‐14 . In this study, the prevalence of EoE/EE in paediatric patients with CD was established.…”

Section: Introductionsupporting

confidence: 68%

“…6,7 It has been suggested that autoimmune and atopic diseases share risk factors that increase the propensity of the immune system to generate both Th1-and Th2-mediated inappropriate responses to nonpathological antigens. 6,8 The coexistence of EoE and CD in the same patient has been reported firstly by Shah et al 9 in 2006. Although CD and EoE/EE are distinct disorders that have different clinicopathological findings, an association between these entities has been postulated in recent years.…”

mentioning

confidence: 54%

“…The prevalence of EoE in paediatric patients with CD has been reported to be 1.2%‐10.7% 8‐13,18‐20 . Lucendo et al 21 reviewed 197 references and found that the prevalence of EoE in CD ranged from 0% to 10.7% and the prevalence of CD in EoE varied from 0.16% to 57.1%.…”

Section: Discussionmentioning

confidence: 99%

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Association of celiac disease with eosophageal eosinophilia and eosinophilic eosophagitis

Urgancı

Usta

Civelek

2021

Int J Clinical Practice

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Background Aim of the study was to evaluate the association between celiac disease and eosinophilic oesophagitis/oesophageal eosinophilia in children. Methods A total of 278 patients with celiac disease (mean age: 7.12 ± 4.64 years, M/F: 0.77) were involved in the study. The patients were evaluated retrospectively in terms of clinical, endoscopic and histopathological findings. The association between celiac disease and eosinophilic oesophagitis/oesophageal eosinophilia was determined. Results According to Marsh classification system 6 (2.1%) of the patients were graded type 3A, 10 (3.5%) were type 3B, 262 (94.4%) were type 3C. The histopathological examination of oesophageal biopsy specimens of the patients revealed <15 eosinophils per high power field in only 4 (1.4%) patients. Two of these patients were positive for HLA DQ8, one was DQ2, and the other one was both DQ8 and DQ2. Tissue transglutaminase IgA level was above 300 U/mL in these patients. None of them had elevated serum total IgE levels, peripheral eosinophilia and history of atopic diseases. The gastrointestinal symptoms resolved and tissue transglutaminase IgA level of the patients were declined after 3 months of gluten‐free diet. Conclusion Although an association between celiac disease and eosinophilic oesophagitis/oesophageal eosinophilia have been postulated in recent years, no exact relationship was established in this study. This is the first study reporting the performance of follow‐up GI endoscopy with biopsies revealing the resolution of oesophageal eosinophilia.

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Section: Introductionsupporting

confidence: 68%

mentioning

confidence: 54%

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Association of celiac disease with eosophageal eosinophilia and eosinophilic eosophagitis

Urgancı

Usta

Civelek

2021

Int J Clinical Practice

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“…The second is that EoE is a disease of relatively recent recognition, particularly in Europe, and such association is not emerged yet. Very recent reports of association between EoE and CD would support this view 17, 18 …”

Section: Discussionmentioning

confidence: 85%

Eosinophilic oesophagitis and coeliac disease: is there an association?

Quaglietta

Coccorullo

Miele

et al. 2007

Aliment Pharmacol Ther

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“…14,21 In recent years, several case reports and cohort studies have suggested an association between EoE and CD. While this association was initially reported for paediatric patients, [22][23][24][25][26] it has since been reiterated in adult patients, 27 but not universally confirmed in large population-based studies. 28 Even though both diseases are caused by aberrant immune responses to ingested antigens and are potentially responsive to a food elimination diet, differences in the underlying pathophysiological mechanisms leading to each of them, 29,30 along with the absence of a genetic connection between EoE and CD, have prevented researchers from establishing a direct relationship.…”

Section: Introductionmentioning

confidence: 94%