Systematic review: the association between eosinophilic oesophagitis and coeliac disease

Lucendo, Alfredo J.; Arias, Ángel; Tenias, Jose María

doi:10.1111/apt.12859

Cited by 42 publications

(38 citation statements)

References 72 publications

(66 reference statements)

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“…Current definitions of EoE stipulate clinical symptoms are necessary for a diagnosis of the disease; however, our findings, including the observation that two-thirds of our patients developed EoE-associated symptoms following the identification of EE, seem to indicate that there may be a presymptomatic stage which may be identified, and thus allow for more careful follow-up of these patients. Furthermore, we found that only a minority of patients with CD+EE have resolution of the EE following a prolonged GFD, similar to previous reports9 10 18 and a meta-analysis 20. In patients with CD, also diagnosed with EoE who respond to GFDs, wheat may be functioning as the triggering antigen of EoE, a finding that has been reported in 26% of children with EoE 21…”

Section: Discussionsupporting

confidence: 90%

Oesophageal eosinophilia in children with coeliac disease

Ari¹,

Morgenstern

Chodick

et al. 2017

Arch Dis Child

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Section: Discussionsupporting

confidence: 90%

Oesophageal eosinophilia in children with coeliac disease

Ari¹,

Morgenstern

Chodick

et al. 2017

Arch Dis Child

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“…This shows that CD and WA are 2 different immune responses to different wheat epitopes. This is not the first attempt to search a link between CD and a Th2-mediated entity: the hypothesis of a relationship between CD and eosinophilic esophagitis was suggested, but there are no consistent studies supporting this hypothesis [10]. …”

Section: Discussionmentioning

confidence: 99%

Celiac Disease and Wheat Allergy: A Growing Association?

Micozzi¹,

Infante²,

Fuentes‐Aparicio³

et al. 2018

Int Arch Allergy Immunol

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Introduction: Celiac disease and wheat allergy (WA) are infrequent diseases in the general population, and a combination of the 2 is particularly rare. Celiac disease occurs in around 1% of the general population and WA in around 1% of all children. Case Report: We report 2 patients with celiac disease and a gluten-free diet who developed WA consistent in anaphylaxis and an eyelid angioedema, respectively, through accidental wheat exposure. A serum study and an intestinal biopsy confirmed celiac disease. Both patients were studied with a skin prick test and serum-specific IgE, with a diagnosis of WA. Discussion: In patients with celiac disease, the trace amounts of cereals present in gluten-free food could act as a sensitization factor, and probably patients with persistent symptoms (despite a gluten-free diet) are experiencing WA symptoms rather than celiac disease symptoms. The number of patients diagnosed with celiac disease has increased in the recent decades: the association between celiac disease and WA, exceedingly rare to date, could increase as well, prompting special attention to the possibility of inadvertent intake of cereals.

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“…A study in children with EoE indicated that 68% had a positive skin or radioallergosorbent test against a median of 7 food allergens [28]. A recent meta-analysis concluded that there is no clear link between EoE and celiac disease [32]. EoE was found with a high prevalence in patients with inherited connective tissue disorders [33].…”

Section: Patient Characteristicsmentioning

confidence: 99%

Eosinophilic Esophagitis, Eosinophilic Gastroenteritis, and Eosinophilic Colitis: Common Mechanisms and Differences between East and West

2016

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Background: Eosinophilic esophagitis (EoE), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EoC) have been diagnosed with an increasing frequency over the last decades. All these diseases share pathogenic similarities with respect to triggering by food antigens in the majority of patients once secondary causes of tissue eosinophilia have been excluded. While diagnostic criteria for EoE have been published, the exact criteria for EGE and EoC still need to be defined. This review highlights similarities and differences between affected patients when comparing the Western with the Eastern world. Summary: The incidence and prevalence of EoE are on the rise in countries from the Western and Eastern world. Very limited epidemiologic data exist regarding EGE and EoC. Characteristics of patients with eosinophilic gastrointestinal disorders regarding gender distribution, age at diagnosis, and associated comorbidities are similar when comparing Eastern with Western countries. Similar modalities are applied to diagnose EoE, EGE, and EoC when comparing Eastern with Western countries. Additionally, comparable therapeutic measures are applied to treat eosinophilic gastrointestinal diseases in Eastern and Western countries. While EoE treatment recommendations are based on increasingly solid evidence, recommendations for the treatment of EGE and EoC are based on low evidence. Key Messages: Eosinophilic gastrointestinal diseases are diagnosed and treated using similar approaches in Eastern and Western countries. Further efforts should be undertaken to help clarify the underlying pathogenic mechanisms and to establish evidence-based diagnostic and therapeutic protocols.

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Systematic review: the association between eosinophilic oesophagitis and coeliac disease

Abstract: SUMMARY BackgroundThe relationship between eosinophilic oesophagitis (EoE) and coeliac disease (CD) remains controversial, with studies yielding varied results.

Cited by 42 publications

References 72 publications

Oesophageal eosinophilia in children with coeliac disease

Oesophageal eosinophilia in children with coeliac disease

Celiac Disease and Wheat Allergy: A Growing Association?

Eosinophilic Esophagitis, Eosinophilic Gastroenteritis, and Eosinophilic Colitis: Common Mechanisms and Differences between East and West

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