Celiac disease (CD), ulcerative colitis (UC), and primary sclerosing cholangitis (PSC) in one patient: a family study

Cadahía, Valle; Rodrigo, Luís; Fuentes, Dolores; Riestra, Sabino; Francisco, Ruth de; Fernández, María Riestra

doi:10.4321/s1130-01082005001200007

Cited by 12 publications

(9 citation statements)

References 16 publications

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“…10 Similar to our patient, three other reports describe convincing evidence of celiac disease and ulcerative colitis. 11–13 All children including our patient responded well to a gluten-free diet and steroid/mesalamine therapy.…”

Section: Discussionmentioning

confidence: 82%

Celiac Disease in a Child With Ulcerative Colitis

Cheng¹,

Raizner²,

Phatak³

et al. 2013

Journal of Clinical Gastroenterology

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Celiac disease and Inflammatory bowel disease (IBD) including ulcerative colitis (UC) and Crohn’s disease are both immune-mediated enteropathies. It is rare for both celiac disease and IBD to occur together in an individual patient. This association has been reported in adults, but very rarely in children. Here, we report an unusual case of an eight-year-old child with a history of anemia and failure to thrive who presented with bloody diarrhea. His evaluation showed anemia, elevated inflammatory markers and positive celiac antibodies. Endoscopic evaluation revealed partial duodenal villous atrophy and pancolitis. He was diagnosed with celiac disease and UC and responded well to a gluten-free diet and steroid/mesalamine therapy. The patient’s genetic testing revealed markers showing susceptibility for both celiac disease and UC. It is important to be aware of this association as both conditions can present with similar clinical features, but require different therapeutic approaches.

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Section: Discussionmentioning

confidence: 82%

Celiac Disease in a Child With Ulcerative Colitis

Cheng¹,

Raizner²,

Phatak³

et al. 2013

Journal of Clinical Gastroenterology

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“…In this cross-sectional study, we examined the coexistence of CeD and IBD in a cohort of pediatric patients. Several case reports in children have described the simultaneous existence of UC and CeD, which can affect both boys and girls [ 16 - 18 ] and can occur in association with PSC [ 19 ]. We found an association between CeD and UC, and an association between CeD and CD in patients.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Celiac Disease in Children and Adolescents With Inflammatory Bowel Disease

Eskander¹,

Saadah²,

Abdel-Razek³

et al. 2020

Cureus

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Introduction The association between inflammatory bowel disease (IBD) - particularly its two main subtypes, ulcerative colitis (UC) and Crohn’s disease (CD) - and celiac disease (CeD) has been attributed to an overlap in the mechanism of immune dysregulation that characterizes these conditions. Owing to the paucity of studies that have explored this condition in pediatric patients, we examined the prevalence of CeD in children with IBD. Materials and methods This is a cross-sectional study of children aged two to 18 years with IBD that were diagnosed between 2016 and 2018. Clinical, demographic, laboratory, and endoscopic data were analysed. Serology for CeD measured the immunoglobulin A tissue transglutaminase (IgA-tTG) antibodies, and the diagnosis was confirmed histologically through small bowel biopsies. Results The study included 101 patients with IBD (83.2% with UC and 16.8% with CD). The mean age was 8.7±4.0 years. Males constituted 59.4% of the cohort, and only 3% had perianal disease. Ileocolonic involvement was reported in 64.7% and non-stricturing and non-penetrating behaviour in 76.7% of CD patients. Pancolitis constituted 45.2% of UC patients. Ten patients (9.9%) had positive serology based on IgA-tTG antibodies, three (approximately 3%) had CeD based on biopsy findings, two patients (2%) had CD, and one patient (1%) had UC. Patients with confirmed CeD had a significantly higher frequency of symptoms of gaseous sensation and bloating (P=0.003) and abdominal distension (P=0.04). Conclusions The prevalence of CeD in Egyptian children with IBD is higher than previously reported in a number of similar studies. Abdominal bloating and gaseous sensation were identified as associated symptoms.

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“…GFD was reported to cause an improvement in hepatic histological characteristics and cholestasis only in a small number of cases, making difficult to confirm whether the diet may slow the progression of this autoimmune liver disorder [64, 65]. …”

Section: Autoimmune Disorders In Celiac Diseasementioning

confidence: 99%

Celiac Disease and Autoimmune-Associated Conditions

Lauret

Rodrigo

2013

BioMed Research International

149

111

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Celiac disease (CD) is frequently accompanied by a variety of extradigestive manifestations, thus making it a systemic disease rather than a disease limited to the gastrointestinal tract. This is primarily explained by the fact that CD belongs to the group of autoimmune diseases. The only one with a known etiology is related to a permanent intolerance to gluten. Remarkable breakthroughs have been achieved in the last decades, due to a greater interest in the diagnosis of atypical and asymptomatic patients, which are more frequent in adults. The known presence of several associated diseases provides guidance in the search of oligosymptomatic cases as well as studies performed in relatives of patients with CD. The causes for the onset and manifestation of associated diseases are diverse; some share a similar genetic base, like type 1 diabetes mellitus (T1D); others share pathogenic mechanisms, and yet, others are of unknown nature. General practitioners and other specialists must remember that CD may debut with extraintestinal manifestations, and associated illnesses may appear both at the time of diagnosis and throughout the evolution of the disease. The implementation of a gluten-free diet (GFD) improves the overall clinical course and influences the evolution of the associated diseases. In some cases, such as iron deficiency anemia, the GFD contributes to its disappearance. In other disorders, like T1D, this allows a better control of the disease. In several other complications and/or associated diseases, an adequate adherence to a GFD may slow down their evolution, especially if implemented during an early stage.

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Celiac disease (CD), ulcerative colitis (UC), and primary sclerosing cholangitis (PSC) in one patient: a family study

Cited by 12 publications

References 16 publications

Celiac Disease in a Child With Ulcerative Colitis

Celiac Disease in a Child With Ulcerative Colitis

Prevalence of Celiac Disease in Children and Adolescents With Inflammatory Bowel Disease

Celiac Disease and Autoimmune-Associated Conditions

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