Celiac Disease in a Child With Ulcerative Colitis

Cheng, Shuk Kei; Raizner, Aileen; Phatak, Uma Padhye; Cho, Judy H.; Pashankar, Dinesh S.

doi:10.1097/mcg.0b013e318250e468

Cited by 7 publications

(10 citation statements)

References 16 publications

(26 reference statements)

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“…In our study, CD was more common than UC in a cohort of IBD patients. In contrast to our results, CeD were reported more frequently to be associated with UC than CD [ 10 , 17 – 19 ]. Moreover, two further studies reported high prevalence of UC even among the first-degree relatives of patients with CeD [ 20 , 21 ].…”

Section: Discussioncontrasting

confidence: 99%

Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

et al. 2015

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BackgroundCeliac disease, Crohn disease and ulcerative colitis are inflammatory disorders of the gastrointestinal tract with some common genetic, immunological and environmental factors involved in their pathogenesis. Several research shown that patients with celiac disease have increased risk of developing inflammatory bowel disease when compared with that of the general population. The aim of this study is to determine the prevalence of inflammatory bowel disease in our celiac patient cohort over a 15-year-long study period.MethodsTo diagnose celiac disease, serological tests were used, and duodenal biopsy samples were taken to determine the degree of mucosal injury. To set up the diagnosis of inflammatory bowel disease, clinical parameters, imaging techniques, colonoscopy histology were applied. DEXA for measuring bone mineral density was performed on every patient.ResultsIn our material, 8/245 (3,2 %) coeliac disease patients presented inflammatory bowel disease (four males, mean age 37, range 22–67), 6/8 Crohn’s disease, and 2/8 ulcerative colitis. In 7/8 patients the diagnosis of coeliac disease was made first and inflammatory bowel disease was identified during follow-up. The average time period during the set-up of the two diagnosis was 10,7 years. Coeliac disease serology was positive in all cases. The distribution of histology results according to Marsh classification: 1/8 M1, 2/8 M2, 3/8 M3a, 2/8 M3b. The distribution according to the Montreal classification: 4/6 Crohn’s disease patients are B1, 2/6 Crohn’s disease patients are B2, 2/2 ulcerative colitis patients are S2. Normal bone mineral density was detected in 2/8 case, osteopenia in 4/8 and osteoporosis in 2/8 patients.ConclusionsWithin our cohort of patients with coeliac disease, inflammatory bowel disease was significantly more common (3,2 %) than in the general population.

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Section: Discussioncontrasting

confidence: 99%

Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

et al. 2015

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“…These shared genetic pathways may be the reason for their possible comorbidity. Similarly, a clinical presentation described by Cheng et al was found to be in line with a meta-analysis of genome-wide association study datasets comprising case reports of CeD and IBD comorbidity in Caucasian children from Europe [12,13].…”

Section: Discussionsupporting

confidence: 73%

Celiac disease and ulcerative colitis as comorbid diseases – the diagnostic challenge

Graczyk¹,

Makowska²,

Łężyk-Ciemniak³

et al. 2022

polp

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This study reports the case of a 17-year-old girl with a medical history of abdominal pains, diarrhoea, nausea, vomiting, weight loss, and stools with mucus and blood. The patient was diagnosed with celiac disease (CeD) and ulcerative colitis. No improvement was observed after a gluten-free diet, metronidazole, mesalazine, and systemic steroid treatment. The patient was administered azathioprine, and the systemic steroid therapy was repeated. The clinical condition worsened, and so Infliximab induction treatment was initiated; however, it was discontinued due to lack of response. Cyclosporine treatment was provided with good results. This case is particularly significant because, although the co-occurrence of CeD and inflammatory bowel disease in children is rare, bearing in mind the possible relationship between these disease entities in the diagnosis and treatment of children with gastrointestinal complaints may improve clinical practice and prevent the incorrect diagnosis or worsening the patient's clinical condition and delaying the implementation of appropriate treatment.

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“…Duodenitis in 7% of children was associated with features of functional dyspepsia and functional abdominal pain. Interestingly, there was one patient with concomitant ulcerative colitis and celiac disease who has been described before by us as a case report (4). This patient was classified as a celiac disease patient.…”

Section: Resultsmentioning

confidence: 83%

Prevalence and Clinical, Endoscopic, and Pathological Features of Duodenitis in Children

Alper

Hardee²,

Rojas‐Velasquez³

et al. 2016

J. pediatr. gastroenterol. nutr.

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Objectives While gastritis and esophagitis are well studied in children, there is very limited literature on duodenitis in children. We aimed to assess the prevalence, etiology, clinical, endoscopic, and pathological features in a large cohort of unselected children with duodenitis. Methods We reviewed the pathology reports of all upper endoscopies performed at our institution over 5 years to identify children with duodenitis. Biopsy sections were reviewed to confirm the diagnosis of duodenitis. Demographic, clinical, endoscopic data and presence of associated gastritis and esophagitis were noted in all children with duodenitis. Etiology of duodenitis was correlated with the patient's clinical diagnosis. Results Out of 2772 children who had endoscopy, 352 had duodenitis with the prevalence rate of 12.7%. Gastritis was seen in 64% of children with duodenitis compared with 46% of children without duodenitis (P < 0.001). Common indications for endoscopy in children with duodenitis were abdominal pain, positive celiac serology and diarrhea. The most common etiology was celiac disease (32%), followed by Crohn's disease (13%), ulcerative colitis (3%), and Helicobacter pylori infection (6%). In 63% of cases, endoscopic appearance of duodenum was normal. Cryptitis, villous changes and cellular infiltration were noted on histology. Conclusions Prevalence of duodenitis is 12.7% in children undergoing endoscopy. Celiac disease and inflammatory bowel disease are common causes of duodenitis. Associated gastritis is common in children with duodenitis and correlation of endoscopic appearance with histology is poor.

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Celiac Disease in a Child With Ulcerative Colitis

Cited by 7 publications

References 16 publications

Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

Celiac disease and ulcerative colitis as comorbid diseases – the diagnostic challenge

Prevalence and Clinical, Endoscopic, and Pathological Features of Duodenitis in Children

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