Celiac disease and other precursors to small-bowel malignancy

Green, Peter H. R.; Jabrì, Bana

doi:10.1016/s0889-8588(03)00008-x

Cited by 8 publications

(14 citation statements)

References 95 publications

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“…However, there are several precursor states for small intestinal adenocarcinoma which include familial polyposis syndromes, coeliac disease, and Crohn's disease. 20 Although the association between coeliac disease and small bowel adenocarcinoma is well established, it is based on only a small number of patients and most of the existing literature is in the form of case reports. 7 8 13-15 In a large collaborative study conducted by Swinson et al in the UK, 3 235 coeliac patients were found to have 259 malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…4 Our patient had no other risk factor for small bowel adenocarcinoma. 20 Most of the literature concerning series of patients with adenocarcinoma and coeliac disease were published in the 1970s and 1980s, in patients with longstanding malabsorption. In comparison, our patients were all diagnosed with carcinoma due to coeliac disease in the late 1990s.…”

Section: Discussionmentioning

confidence: 99%

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Small bowel neoplasia in coeliac disease

Rampertab

2003

Gut

109

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Small bowel neoplasia in coeliac disease

Rampertab

2003

Gut

109

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“…Autoimmune diseases are generally more prevalent in females compared to males, possibly due to differences in hormonal factors, though the exact reasons for this are unknown. Mechanisms responsible for the development of lymphomas arising from autoimmunity also remain to be elucidated; however, chronic antigenic stimulation, deficiencies in immune surveillance, and in the case of intestinal autoimmune diseases, increased intestinal permeability to environmental carcinogens, have been proposed [24,25]. Given the relatively long latency between disease and lymphomagenesis, a multistep process of genetic instability and consequential alterations is probable for disease progression.…”

Section: Evidence Of Inflammation and Cancermentioning

confidence: 99%

“…Crohn's disease patients with a similar extent and severity of inflammatory involvement in the colon as ulcerative colitis patients have similar risks for development of colorectal cancer [86]. Celiac disease, which is generally restricted to the small intestine, is strongly associated with development of small-bowel adenocarcinoma, with patients having an 80-fold greater risk than the general population [24,75,87]. …”

Section: Intestinal Inflammation and Associated Cancersmentioning

confidence: 99%

Mechanisms of intestinal inflammation and development of associated cancers: Lessons learned from mouse models

Westbrook

Szakmary

Schiestl

2010

Mutation Research/Reviews in Mutation Research

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Chronic inflammation is strongly associated with approximately 1/5 th of all human cancers. Arising from combinations of factors such as environmental exposures, diet, inherited gene polymorphisms, infections, or from dysfunctions of the immune response, chronic inflammation begins as an attempt of the body to remove injurious stimuli; however, over time, this results in continuous tissue destruction and promotion and maintenance of carcinogenesis. Here we focus on intestinal inflammation and its associated cancers, a group of diseases on the rise and affecting millions of people worldwide. Intestinal inflammation can be widely grouped into inflammatory bowel diseases (ulcerative colitis and Crohn's disease) and celiac disease. Long-standing intestinal inflammation is associated with colorectal cancer and small-bowel adenocarcinoma, as well as extraintestinal manifestations, including lymphomas and autoimmune diseases. This article highlights potential mechanisms of pathogenesis in inflammatory bowel diseases and celiac disease, as well as those involved in the progression to associated cancers, most of which have been identified from studies utilizing mouse models of intestinal inflammation. Mouse models of intestinal inflammation can be widely grouped into chemically induced models; genetic models, which make up the bulk of the studied models; adoptive transfer models; and spontaneous models. Studies in these models have lead to the understanding that persistent antigen exposure in the intestinal lumen, in combination with loss of epithelial barrier function, and dysfunction and dysregulation of the innate and adaptive immune responses lead to chronic intestinal inflammation. Transcriptional changes in this environment leading to cell survival, hyperplasia, promotion of angiogenesis, persistent DNA damage, or insufficient repair of DNA damage due to an excess of proinflammatory mediators are then thought to lead to sustained malignant transformation. With regards to extraintestinal manifestations such as lymphoma, however, more suitable models are required to further investigate the complex and heterogeneous mechanisms that may be at play.

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“…Whatever causes the development of these two related diseases in the same patient, it needs to be investigated further; however, the commitment of an astute physician is required to detect the second latent disease in advance, before any serious consequences—such as, for example, intestinal lymphoma—can occur 20 , 21…”

Section: Discussionmentioning

confidence: 99%

Long term diarrhoea caused by simultaneous Crohn's disease and coeliac disease in the same patient

Asadi

Malekzadeh²,

Roshan³

2010

Case Reports

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Coeliac disease and Crohn's disease are among the most well known gastrointestinal disorders, with distinct pathogenic mechanisms. However, because of some overlapping features between these two conditions, there may be some inevitable misdiagnoses. In addition, diarrhoea and changes in bowel habit may lead the physician to misdiagnose more common disorders such as irritable bowel syndrome. There are a few cases reporting both coeliac and Crohn's disease in the same patient. Here we report a case of a 32-year-old woman suffering from long term diarrhoea who was eventually discovered to have coeliac disease and Crohn's disease simultaneously.

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Celiac disease and other precursors to small-bowel malignancy

Cited by 8 publications

References 95 publications

Small bowel neoplasia in coeliac disease

Small bowel neoplasia in coeliac disease

Mechanisms of intestinal inflammation and development of associated cancers: Lessons learned from mouse models

Long term diarrhoea caused by simultaneous Crohn's disease and coeliac disease in the same patient

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