Small bowel neoplasia in coeliac disease

Rampertab, S. Devi

doi:10.1136/gut.52.8.1211

Cited by 108 publications

(74 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A further contribution to NF-κB activation also is determined by the upregulation of RAN protein (62) and of PRDX4 (63), and by the downregulation of PEBP1, also known as RKIP (64,65), all of which we found modulated in our series (Table 3). It is known that adult CD patients present a higher risk of developing cancer than the general population (4,5). In our series, we found the upregulation of known cancer-related proteins (RAN and PRDX4) (62,63) and the downregulation of PEBP1 (65).…”

Section: N T E S T I N a L M U C O S A T I S S U E P R O T E O M E supporting

confidence: 53%

“…The prognosis of this subgroup of patients is poor, and they show a higher risk of developing an overt lymphoma and uncontrolled malabsorption. Moreover, overall CD patients present a higher risk of developing cancer (4,5). Cancers include T-and B-cell nonHodgkin lymphoma, oropharyngeal, esophageal and intestinal adenocarcinomas and pancreas tumors (6).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

PPAR Signaling Pathway and Cancer-Related Proteins Are Involved in Celiac Disease-Associated Tissue Damage

Simula

Cannizzaro

Canzonieri

et al. 2010

Mol Med

View full text Add to dashboard Cite

Celiac disease (CD) is an immune-mediated disorder triggered by the ingestion of wheat gliadin and related proteins in genetically predisposed individuals. To find a proteomic CD diagnostic signature and to gain a better understanding of pathogenetic mechanisms associated with CD, we analyzed the intestinal mucosa proteome alterations using two dimensional difference gel electrophoresis (2D-DIGE) coupled with matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF ms) of CD patients with varying degrees of histological abnormalities defined by Marsh criteria and controls. Our results clearly evidenced the presence of two groups of patients: Group A, including controls and Marsh 0-I CD patients; and Group B, consisting of CD subjects with grade II-III Oberhuber-Marsh classification. Differentially expressed proteins were involved mainly in lipid, protein and sugar metabolism. Interestingly, in Group B, several downregulated proteins (FABP1, FABP2, APOC3, HMGCS2, ACADM and PEPCK) were implicated directly in the peroxisome proliferator-activated receptor (PPAR) signaling pathway. Moreover, Group B patients presented a deregulation of some proteins involved in apoptosis/survival pathways: phosphatidylethanolamine-binding protein 1 (PEBP1), Ras-related nuclear protein (Ran) and peroxiredoxin 4 (PRDX4). PEBP1 downregulation and RAN and PRDX4 upregulation were associated with more severe tissue damage. Likewise, IgMs were found strongly upregulated in Group B. In conclusion, our results indicate that a downregulation of proteins involved in PPAR signaling and the modulation of several cancer-related proteins are associated with the highest CD histological score according to Oberhuber-Marsh classification.

show abstract

Section: N T E S T I N a L M U C O S A T I S S U E P R O T E O M E supporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

PPAR Signaling Pathway and Cancer-Related Proteins Are Involved in Celiac Disease-Associated Tissue Damage

Simula

Cannizzaro

Canzonieri

et al. 2010

Mol Med

View full text Add to dashboard Cite

show abstract

“…Although in the great majority of patients the prognosis of this disease is excellent, and most coeliac patients die for causes unrelated to CD, some of these patients may develop a series of serious complications, such as refractory CD type 1 and type 2 (RCD1 and RCD2), ulcerative jejunoileitis (UJI), enteropathyassociated T-cell lymphoma (EATL), abdominal B cell lymphoma (ABL), and small bowel carcinoma (SBC), which dramatically reduce ଝ This project was supported by a grant from the Fondazione Celiachia "Studio di possibili fattori ambientali e sviluppo di nuove strategie terapeutiche nelle complicanze della malattia celiaca". The funding source had no role.the prognosis [3][4][5][6][7]. In particular, the five-year survival rate is between 80% and 96% in patients with RCD1, between 40% and 58% in patients with RCD2 and drops to less than 20% in patients with CD complicated by EATL [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…The first papers on the molecular diagnosis of complicated CD (CCD) were published more than 10 years ago [14], and since then several papers were published on this subject [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Despite these achievements, the literature still provides only minor and insufficient indications on the incidence of these conditions in patients with CD [8,[15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Low incidence but poor prognosis of complicated coeliac disease: A retrospective multicentre study

Biagi

Gobbi

Marchese

et al. 2014

Digestive and Liver Disease

View full text Add to dashboard Cite

“…In CD patients, exposure to gluten results in chronic inflammation of the small bowel mucosa characterized by intraepithelial lymphocytosis, crypt hyperplasia and villous atrophy (3,4). CD is a well-established risk factor for small bowel lymphoma (5)(6)(7). In several recent studies on CD patients, the association with small bowel adenocarcinomas (SBAs) was also investigated, and a relative risk of 10-to 80-fold for this tumor type was reported for CD (6,8,9).…”

Section: Introductionmentioning

confidence: 99%

Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway

et al. 2010

View full text Add to dashboard Cite

Abstract. Celiac disease (CD) is an inflammatory disorder associated with an increased risk of small bowel adenocarcinoma. Recent studies have demonstrated aberrant CpG island methylation (CIM) in chronic inflammation, aging and cancer. We hypothesized that CIM may link CD to small bowel carcinogenesis. We determined microsatellite instability (MSI), CIM, and expression of MLH1 and MGMT in 3 CDassociated small bowel carcinomas and corresponding nonneoplastic mucosa. The results were compared to those of small bowel mucosa from CD patients without carcinoma and 20 small bowel carcinomas from a non-CD origin. A high level CIM/MSI phenotype was found in all of the 3 CDassociated carcinomas and was associated with loss of MLH1 expression due to hypermethylation of the MLH1 promoter. This phenotype was noted in only 2 of the 20 investigated non-CD-associated carcinomas. Low-level CIM was already detectable in 9 of the 12 non-neoplastic mucosa samples of CD patients and in non-CD-associated carcinomas of elderly patients. In conclusion, our data reveal that the high-level CIM/MSI pathway is typical of CD-associated small bowel carcinomas and indicate that aberrant CpG island methylation links CD and carcinogenesis. The data further suggest that CD should be considered in patients with small bowel adenocarcinoma, particularly when the tumors display MSI.

show abstract

Small bowel neoplasia in coeliac disease

Cited by 108 publications

References 23 publications

PPAR Signaling Pathway and Cancer-Related Proteins Are Involved in Celiac Disease-Associated Tissue Damage

PPAR Signaling Pathway and Cancer-Related Proteins Are Involved in Celiac Disease-Associated Tissue Damage

Low incidence but poor prognosis of complicated coeliac disease: A retrospective multicentre study

Small bowel adenocarcinomas in celiac disease follow the CIM-MSI pathway

Contact Info

Product

Resources

About