Celiac Disease and Epilepsy: The Effect of Gluten-Free Diet on Seizure Control

Bashiri, Homayoon; Afshari, Darioush; Babaei, Nosrat; Ghadami, Mohammad Rasoul

doi:10.17219/acem/43585

Cited by 31 publications

(31 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, the implementation of a gluten-free diet in epileptic patients may contribute to a decrease of antiepileptic medication use. On a clinical level, CD screening may be advisable as a gluten free diet could possibly replace the need for medication and reduce the occurrence of seizures [ 136 ].…”

Section: Systemic Inflammationmentioning

confidence: 99%

The role of inflammation in the development of epilepsy

Rana

Musto

2018

J Neuroinflammation

479

328

View full text Add to dashboard Cite

Epilepsy, a neurological disease characterized by recurrent seizures, is often associated with a history of previous lesions in the nervous system. Impaired regulation of the activation and resolution of inflammatory cells and molecules in the injured neuronal tissue is a critical factor to the development of epilepsy. However, it is still unclear as to how that unbalanced regulation of inflammation contributes to epilepsy. Therefore, one of the goals in epilepsy research is to identify and elucidate the interconnected inflammatory pathways in systemic and neurological disorders that may further develop epilepsy progression. In this paper, inflammatory molecules, in neurological and systemic disorders (rheumatoid arthritis, Crohn’s, Type I Diabetes, etc.) that could contribute to epilepsy development, are reviewed.Understanding the neurobiology of inflammation in epileptogenesis will contribute to the development of new biomarkers for better screening of patients at risk for epilepsy and new therapeutic targets for both prophylaxis and treatment of epilepsy.

show abstract

Section: Systemic Inflammationmentioning

confidence: 99%

The role of inflammation in the development of epilepsy

Rana

Musto

2018

J Neuroinflammation

479

328

View full text Add to dashboard Cite

show abstract

“…Acute symptomatic as well as unprovoked seizures have been reported in people with autoimmune disorders. Most seizures reported are either convulsions or focal in nature [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Seizures as a clinical manifestation in somatic autoimmune disorders

Amanat

Thijs

Salehi

et al. 2019

Seizure

View full text Add to dashboard Cite

A B S T R A C TThe risk of epileptic seizures seems increased in several systemic autoimmune disorders including systemic lupus erythematosus, type 1 diabetes mellitus, myasthenia gravis, celiac disease, rheumatoid arthritis, Hashimoto's encephalopathy, psoriasis, multiple sclerosis, neuromyelitis optica, and bullous pemphigoid. Immune dysfunction may be partly responsible for this association. Elevated levels of pro-inflammatory cytokines, autoantibodies seen in these autoimmune disorders and antibodies against neuronal antigens may contribute to the etiopathogenesis of seizures and epilepsy associated to immune conditions. Other unknown factors, the effect of different co-morbid conditions of epilepsy as well as shared risk factors such as common etiological factors, environmental triggers, or a common genetic predisposition may also explain the association. We review different autoimmune disorders which may present with co-morbid seizures and discuss possible underlying mechanisms of this co-occurrence focusing on a potential role of immune system dysfunction.

show abstract

“…In particular, a specific type of focal epilepsy associated with occipital calcifications was described by Gobbi and co-workers 19 . This form is characterized by antiepileptic drug-resistant seizures and has been shown to benefit from gluten restriction diet 4 . Since no animal model mimicking all the key factors predisposing to CD (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Data suggest that up to 22% of patients with CD develop neurologic or psychiatric dysfunction 2 , and as many as 57% of people with neurological dysfunction of unknown origin test positive for anti-gliadin antibodies 3 . It is interesting to notice that in “intractable epilepsy”, gluten restriction diet has resulted in a reduction of seizure frequency with a decrease in antiepileptic medication needed to control intractable seizure in humans 4 . Unfortunately, there is no evidence on the casual relation between epilepsy and GRD and it remains unclear whether gluten contributes to the pathogenesis of these disorders or whether it represents an epiphenomenon.…”

Section: Introductionmentioning

confidence: 99%

The gliadin peptide 31-43 exacerbates kainate neurotoxicity in epilepsy models

Gerace

Resta²,

Landucci

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Many neurological disorders of gluten-related diseases (GRD), not directly referable to the gastrointestinal tract, have been reported in association with celiac disease (CD), including ataxia, neuropathy and epilepsy. In particular, people with epilepsy diagnosed with CD seems to be characterized by intractable seizure. In these patients, gluten restriction diet has resulted in a reduction of both seizure frequency and antiepileptic medication. Many hypotheses have been suggested, however, molecular mechanisms that associates GRD and epileptogenesis are yet unknown. In this study, we examined the effects of the toxic gliadin peptide 31-43 in in vivo and in vitro models of kainate-induced-epilepsy. We observed that p31-43 exacerbates kainate neurotoxicity in epilepsy models, through the involvement of the enzymatic activity of transglutaminases. Moreover, electrophysiological recordings in CA3 pyramidal neurons of organotypic hippocampal slices show that p31-43 increases the inward current induced by kainate, the average sEPSC amplitude and the total number of evoked action potentials when applicated alone, thus suggesting that p31-43 is able to influence CA3-CA1 neurotransmission and can potentiate postsynaptic kainate receptors. Our results suggest a possible mechanism underlying the relationship between GRD and epilepsy through a potentiation of kainate-induced neurotoxicity and links the toxic effects of gluten to epilepsy.

show abstract

Celiac Disease and Epilepsy: The Effect of Gluten-Free Diet on Seizure Control

Cited by 31 publications

References 14 publications

The role of inflammation in the development of epilepsy

The role of inflammation in the development of epilepsy

Seizures as a clinical manifestation in somatic autoimmune disorders

The gliadin peptide 31-43 exacerbates kainate neurotoxicity in epilepsy models

Contact Info

Product

Resources

About