Celecoxib nanocrystal-loaded dissolving microneedles with highly efficient for osteoarthritis treatment

Wang, Qiuyue; Yang, Xuejing; Gu, Xun; Wei, Fang; Cao, Wenyu; Zheng, Lijie; Li, Yingying; Resoures, Tao Ma; Wu, Chuanbin; Wang, Qingqing

doi:10.1016/j.ijpharm.2022.122108

Cited by 19 publications

(7 citation statements)

References 35 publications

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“…For a better therapeutic effect, Qiuyue Wang et al 140 developed dissolving MNs loaded with CXB-nanocrystals (CXB-NCs), which can significantly improve the water solubility and loading capacity of CXB in MNs while avoiding the first-pass effect. It can effectively modify the inflammatory cell infiltration, joint destruction, and swelling within the joints in the rat model with sustained drug release.…”

Section: Osteoarthritismentioning

confidence: 99%

“…151 In this situation, some nanomaterials such as liposomes, micelles, and nanoparticles have been combined with MNs to solve the problems, improving the bioavailability and half-life of the drugs as well. 97,140,150,152 However, the toxicity of nanomaterials is not negligible, though sometimes their surface has been modified with certain polymers or compounds to minimize the toxicity. 153 Further elucidating and eliminating the toxicological effects of nanomaterials to obtain the optimal therapeutic effects is of great value for the TDD administration of various types of arthritis with MNs.…”

Section: Osteoarthritismentioning

confidence: 99%

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Transdermal drug delivery via microneedles for musculoskeletal systems

Zheng¹,

Xie²,

Ling³

et al. 2023

J. Mater. Chem. B

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Section: Osteoarthritismentioning

confidence: 99%

Section: Osteoarthritismentioning

confidence: 99%

Transdermal drug delivery via microneedles for musculoskeletal systems

Zheng¹,

Xie²,

Ling³

et al. 2023

J. Mater. Chem. B

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“…Their shape allows for pain-free application and the creation of micropores, serving as new pathways for the penetration of hydrophilic and macromolecule drugs into the skin [ 12 ]. Microneedles offer a viable option for delivering a wide range of drug and biopharmaceutical molecules [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Importantly, patients do not require medical assistance to apply microneedles, improving patient compliance [ 29 , 30 ].…”

Section: The Transdermal Route As An Alternative For Biomacromolecule...mentioning

confidence: 99%

Microneedle-Mediated Transdermal Delivery of Genetic Materials, Stem Cells, and Secretome: An Update and Progression

Nainggolan,

Anjani,

Hartrianti

et al. 2023

Pharmaceutics

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Medical practitioners commonly use oral and parenteral dosage forms to administer drugs to patients. However, these forms have certain drawbacks, particularly concerning patients’ comfort and compliance. Transdermal drug delivery presents a promising solution to address these issues. Nevertheless, the stratum corneum, as the outermost skin layer, can impede drug permeation, especially for macromolecules, genetic materials, stem cells, and secretome. Microneedles, a dosage form for transdermal delivery, offer an alternative approach, particularly for biopharmaceutical products. In this review, the authors will examine the latest research on microneedle formulations designed to deliver genetic materials, stem cells, and their derivatives. Numerous studies have explored different types of microneedles and evaluated their ability to deliver these products using preclinical models. Some of these investigations have compared microneedles with conventional dosage forms, demonstrating their significant potential for advancing the development of biotherapeutics in the future.

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“…The natural polymers hyaluronic acid (HA) and chondroitin sulfate (CS) [ 21 ], as the main components of human joint synovial fluid [ 22 ], are widely used in arthritis treatment and can also be used as materials for preparing dissolving MNs [ 23 , 24 ]. In the treatment of RA, MNs are ideal drug delivery vehicles to directly deliver drugs into the joints [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Co-Delivery of Loxoprofen and Tofacitinib by Photothermal Microneedles for Rheumatoid Arthritis Treatment

et al. 2023

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Rheumatoid arthritis (RA) is an autoimmune disease of synovial inflammation that affects populations worldwide. Transdermal drug delivery systems for treating RA have increased but remain challenging. We fabricated a dissolving microneedle (MN) system with photothermal (PT) polydopamine (PDA) to co-load the non-steroidal anti-inflammatory drug loxoprofen (Lox) and the Janus kinase inhibitor tofacitinib (Tof), with the aim of co-delivering Lox and Tof directly to the articular cavity, aided by the combination of MN and PT. In vitro and in vivo permeation studies showed that the PT MN significantly promoted drug permeation and retention in the skin. An in vivo visualization of the drug distribution in the articular cavity showed that the PT MN significantly promoted drug retention in the articular cavity. Importantly, compared to the intra-articular injection of Lox and Tof, the application of the PT MN to a carrageenan/kaolin-induced arthritis rat model exhibited superior performance in reducing joint swelling, muscle atrophy, and cartilage destruction. Furthermore, the PT MN downregulated the mRNA expression levels of proinflammatory cytokines, including TNF-α, IL-1β, iNOS, JAK2, JAK3, and STAT3. The results show that the PT MN transdermal co-delivery of Lox and Tof is a new synergetic therapy with high compliance and good therapeutic efficacy for RA.

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Celecoxib nanocrystal-loaded dissolving microneedles with highly efficient for osteoarthritis treatment

Cited by 19 publications

References 35 publications

Transdermal drug delivery via microneedles for musculoskeletal systems

Transdermal drug delivery via microneedles for musculoskeletal systems

Microneedle-Mediated Transdermal Delivery of Genetic Materials, Stem Cells, and Secretome: An Update and Progression

Co-Delivery of Loxoprofen and Tofacitinib by Photothermal Microneedles for Rheumatoid Arthritis Treatment

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