Celecoxib‐induced photoallergic drug eruption

Abstract

Photoallergic dermatitis is caused by a photosensitizing substance plus sunlight exposure in a sensitized person. If the photosensitizer is delivered internally, it is called a photoallergic drug reaction. Celecoxib is a new generation non-steroidal anti-inflammatory drug and sulfonamide derivative. We report a photoallergic drug eruption associated with the introduction of celecoxib. To our knowledge, this is the first report of photoallergic drug reaction associated with celecoxib.

Celecoxib-induced erythema multiforme-type drug eruption with a positive patch test

“…To date, a patch test, LTT or oral challenge test have been performed in only 10 reported cases of celecoxib‐induced drug eruption in the English‐language published work (Table 1). 2–9 A positive patch test for celecoxib was reported in six of eight evaluable cases, an LTT was positive in two of three cases, and an oral challenge test was positive in two of two cases. Thus, celecoxib was identified as the causative drug by one or more allergy test in nine of 10 cases.…”

“…Celecoxib was first used in the USA in 1999 1 and is now in common use worldwide due to its lower rate of gastrointestinal irritation compared to non‐selective NSAIDs 2 . With increased use, there has been an increase in the reports of drug eruptions due to celecoxib, 1 but only a few cases with diagnosis using tests such as the patch test, lymphocyte transformation test (LTT) or oral challenge test have been described 2–9 . Here, we report a case of erythema multiforme‐type drug eruption due to celecoxib that showed a positive patch test.…”

Generation of reactive intermediates in photoallergic dermatitis

“…Since the 1970s, these drugs have been available for topical treatment of inflammatory conditions and pain. As regards photoallergic dermatitis elicited by NSAIDs, it is more frequent for the topically administered drugs, although a number of cases of photoallergy caused by systemic administration have also been reported [25,26].…”

Phototoxic and Photoallergic Reactions

“…Sulphonamide antibacterials, as well as sulfa-drug analogs (thiazidic diuretics, hypoglycemic sulfonylureas, and celecoxib) and dapsone (diamidiphenylsulfone), have been reported to cause photosensitivity within the spectrum both of UVB and UVA [51,87,88], but this side effect is not so frequent with the most currently used cotrimoxazole (trimethoprim/sulfamethoxazole) [14,51].…”