Celecoxib as an in vivo probe of cyclooxygenase-2 mechanisms underlying retrograde amnesia in an animal model of ECT

Abstract

Celecoxib may protect against ECS-induced retrograde amnesia by attenuating ECS-induced, COX-2-mediated glutamatergic excitotoxicity.

Antidepressant Augmentation With Anti-Inflammatory Agents

“…NSAIDs have been studied in psychiatry in contexts ranging from the prevention of amnestic deficits associated with electroconvulsive therapy [31][32][33] to the treatment of Alzheimer's disease. 34 Readers who are interested in the subject may wish to consult 2 recent reviews 35,36 that examined the use of anti-inflammatory treatments in psychiatric disorders.…”

Molecular mechanisms underlying electroconvulsive therapy-induced amnestic deficits: A decade of research

“…Our lines of investigation followed two paths: we studied whether attenuating the systolic blood pressure surge during ECT results in decreased cognitive adverse effects[176–180] and we investigated the involvement of specific neurotransmitter mechanisms in ECT-induced amnestic deficits. [181–184] Curiously, two of the blood pressure surge studies themselves suggested neurotransmitter mechanisms. [177–178]…”

“…Other reverberating circuits (including those that involve retrograde neurotransmission through arachidonic acid) that amplify the NMDA signal also develop. [183184] The net effect is glutamate- and NMDA-dependent initiation of LTP in the hippocampus, and thence the hardwiring of learning and memory through neuroplasticity changes.…”

Continuing medical education

“…NSAIDs may impair cognition because, by inhibiting cyclooxygenase mechanisms, they interfere with glutamate-dependent learning and memory;[1112] but these drugs may protect against Alzheimer's disease by inhibiting the neurodegeneration resultant from the inflammatory response to amyloid. The mechanism which predominates may depend on the drug and the state of the brain at the period of administration.…”