Ceftazidime Versus Aztreonam in the Treatment of Pseudomonal Chronic Suppurative Otitis Media in Children

Abstract

In a prospective, open, randomized trial, ceftazidime was given to 15 children and aztreonam to another 15 children with chronic suppurative otitis media without cholesteatoma (CSOM). Patients enrolled to the study had a pure culture of Pseudomonas aeruginosa growing in middle ear discharge. The subjects' mean age was 56 months in the ceftazidime group and 48 months in the aztreonam group. Success rate, defined as complete disappearance of discharge, was 84.6% in the ceftazidime treated patients and 67% in the aztreonam group (p value not significant). The number of days required for complete dryness of the ear was 7.9 and 8.4 respectively. Two patients in each group had recurrence of suppurative discharge within 90 d from discontinuation of antibiotic treatment. These results suggest that aztreonam is an optional alternative systemic treatment for paediatric patients with pseudomonal CSOM, especially in subjects allergic to penicillin.

Bacterial Profile of Middle Ear Infections, Coeixstence of Pseudomonas, Proteus Species in Middle Ear Infections and Their Antibiotic Sensitivity Pattern

“…The resistivity is either due to dose of antibiotic or due to insufficient time. (13) Sensitivity of ciprofloxacin and penicillin against S. aures is about 57-80% and resistance against streptomycin, vancomycin and trimethoprim is almost 83%. (14) As there is no objective picture of the frequency of different bacteria and coexistence of pseudomonas and proteus in patients visiting Mayo hospital OPD, so the topic was selected to get a clear and objective picture of the situation.…”