Cefotetan-induced hemolysis associated with antibiotic prophylaxis for cesarean delivery

Naylor, Charlotte; Steele, Lisa; Hsi, Rock; Margolin, Malcolm; Goldfinger, Dennis

doi:10.1067/mob.2000.106132

Cited by 11 publications

(8 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[313][314][315][316][317][327][328][329][330][331][332][333][334][335][336][337][338][339]344,345 • The DAT is positive due to C3 or IgG plus C3. • In adults, the reaction tends to become apparent after the patient has received the drug for a day or two.…”

Section: P At I E N Tmentioning

confidence: 99%

Drug-Induced Immune Hemolytic Anemia

Petz

2004

Immune Hemolytic Anemias

View full text Add to dashboard Cite

Section: P At I E N Tmentioning

confidence: 99%

Drug-Induced Immune Hemolytic Anemia

Petz

2004

Immune Hemolytic Anemias

View full text Add to dashboard Cite

“…20 Prior to this review, case and case series reports involving 60 patients with hemolytic anemia associated with this drug had been documented. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Immune hemolytic anemia (IHA) secondary to sensitization with cefotetan can result from several types of interactions between the drug, antibodies, and RBC membrane components. These include drug adsorption onto the RBCs, neoantigen ("immune complex") formation, and induction of autoantibodies.…”

Section: Discussionmentioning

confidence: 99%

Cefotetan-induced immune hemolytic anemia following prophylaxis for cesarean delivery

Shariatmadar¹,

Storry

Sausais

et al. 2004

Immunohematology

View full text Add to dashboard Cite

Second-and third-generation cephalosporins, notably cefotetan, are increasingly implicated in severe, sometimes fatal immunemediated hemolytic anemia. We describe a 26-year-old woman who developed severe hemolytic anemia 2 weeks after receiving a single prophylactic dose of cefotetan during cesarean delivery. The patient's DAT was weakly reactive for IgG and her serum reacted with cefotetan-coated RBCs. The antibody had a titer of 4096 by antiglobulin testing. The patient required treatment with two units of PRBCs and experienced gradual resolution of hemolysis. Our case emphasizes the need for increased awareness of delayed onset hemolytic anemia following prophylactic use of cefotetan.

show abstract

“…The anaemia appeared to be caused by cefotetan hemolysis, because the abdominal CT scan showed no hemoperitoneum and the Coombs erythrocytes test result was positive. 3,4 Alternatively, the anaemia could have been caused by paraneoplastic hemolysis; however, we discounted this possibility as being From the …”

mentioning

confidence: 95%

Leiomyosarcoma of the inferior vena cava involving the renal veins: A simple method of right renal vein reimplantation

Tranchart

Carloni

Balzarotti

et al. 2008

Journal of Vascular Surgery

View full text Add to dashboard Cite

In this report we describe a case of leiomyosarcoma of the inferior vena cava involving the renal veins. The abdominal computed tomography scan showed a tumor in the infrahepatic portion of the inferior vena cava and the confluence of the renal veins. After resection of the tumor, venous reconstruction involved the replacement of the inferior vena cava with a prosthetic graft and the implantation of the right renal vein into the portal vein. The left renal vein was ligated distally, with preservation of collateral pathways. To our knowledge, no other reports of such venous reconstruction have been published. After a follow-up of 30 months, the patient has shown no further symptoms, and the abdominal computed tomography scan demonstrates patency of the renal portal anastomosis. Tests indicated normal renal and hepatic function, suggesting good tolerance of the renal portal anastomosis. We believe that the technique described in this report should be adopted routinely for tumors located in the renal veins, provided complete resection of the tumor with a comfortable resection margin is possible.

show abstract

Cefotetan-induced hemolysis associated with antibiotic prophylaxis for cesarean delivery

Cited by 11 publications

References 2 publications

Drug-Induced Immune Hemolytic Anemia

Drug-Induced Immune Hemolytic Anemia

Cefotetan-induced immune hemolytic anemia following prophylaxis for cesarean delivery

Leiomyosarcoma of the inferior vena cava involving the renal veins: A simple method of right renal vein reimplantation

Contact Info

Product

Resources

About