Cefmetazole sodium as an allosteric effector that regulates the oxygen supply efficiency of adult hemoglobin

Shu, Peilin; You, Guoxiang; Li, Weidan; Chen, Yuzhi; Chu, Zongtang; Dong, Qian; Wang, Ying; Zhou, Hong; Zhao, Lei

doi:10.1080/07391102.2023.2245043

Cited by 1 publication

(1 citation statement)

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“…Hemoglobin (Hb), the main O 2 carrier in RBCs, facilitates O 2 delivery via its well-known oxygen-carrying function [ 21 ]. In adults, Hb consist of four subunits (α1, β1, α2, and β2) that form a tetrameric protein containing a central ferrous heme, enabling it to transport O 2 by binding reversibly to O 2 [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial-related hemoglobin-based oxygen carriers, with emphasis on liposome and nano-capsules, for biomedical applications: current status and future perspectives

Zhu,

Wang,

Xiao

et al. 2024

J Nanobiotechnol

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Oxygen is necessary for life and plays a key pivotal in maintaining normal physiological functions and treat of diseases. Hemoglobin-based oxygen carriers (HBOCs) have been studied and developed as a replacement for red blood cells (RBCs) in oxygen transport due to their similar oxygen-carrying capacities. However, applications of HBOCs are hindered by vasoactivity, oxidative toxicity, and a relatively short circulatory half-life. With advancements in nanotechnology, Hb encapsulation, absorption, bioconjugation, entrapment, and attachment to nanomaterials have been used to prepare nanomaterial-related HBOCs to address these challenges and pend their application in several biomedical and therapeutic contexts. This review focuses on the progress of this class of nanomaterial-related HBOCs in the fields of hemorrhagic shock, ischemic stroke, cancer, and wound healing, and speculates on future research directions. The advancements in nanomaterial-related HBOCs are expected to lead significant breakthroughs in blood substitutes, enabling their widespread use in the treatment of clinical diseases. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%