Cefazolin sodium pentahydrate combined with vacuum sealing drainage in the treatment of open fracture complicated with soft tissue injury

Abstract

<jats:p>SUMMARY OBJECTIVE To investigate the clinical efficacy of cefazolin sodium pentahydrate combined with vacuum sealing drainage (VSD) in the treatment of open fracture complicated with soft tissue injury. METHODS Sixty-three patients with open fracture complicated with soft tissue injury were divided into observation (n = 33) and control (n = 30) groups. After surgical reduction, fixation, and repair of the fractures, the control group was treated with VSD for 10 days, and the observation group was treated with cefazolin sodium pentahydrate based on VSD for 10 days. The infection control time was recorded. After treatment, the pain of patients was evaluated. Before and after treatment, the serum levels of C-reactive protein (CRP), interleukin (IL)-6, IL-8, tumor necrosis factor α (TNF-α), cortisol, epinephrine, norepinephrine, and glucose were detected. After 6 months of treatment, the total effective rate of the treatment was evaluated. RESULTS The infection control time and Visual Analogue Scale score after treatment in the observation group were significantly lower than in the control group, respectively (P &lt; 0.05). After the treatment, the serum levels of CRP, IL-6, IL-8, TNF-α, cortisol, epinephrine, norepinephrine, and glucose in each group were significantly lower than before the treatment (P &lt; 0.05), and each index in observation was significantly lower than in the control group (P &lt; 0.05). CONCLUSIONS In the treatment of open fractures complicated with soft tissue injury, cefazolin sodium pentahydrate combined with VSD can effectively reduce inflammation and stress, thus improving the treatment efficacy.</jats:p>

Immunomodulatory activity of aqueous extract from Crassostrea sikamea in the splenocytes of Sprague‐Dawley rats

“…Moreover, lymphocyte proliferation and apoptosis affect the maintenance of the number and ratio of various lymphocyte subsets as well as the general function of immunoregulation. Our results showed that the percentage of CD3 + CD4 + T lymphocytes and the ratio of CD3 Lou et al, 2020). Thus, we detected cytokine levels by ELISA and found that AECs possessed the ability to upregulate the concentrations of TNFα, IL-2, IL-6, IL-12, and IFNγ in splenocytes.…”

“…Activated splenocytes generate and sequentially secrete a variety of inflammatory cytokines to regulate the immune response. An increase in the level of one inflammatory factor can promote the synthesis and secretion of other inflammatory factors through a cascade reaction (Hye & Min, 2016 ; Jin‐Gyo et al., 2018 ; Lou et al., 2020 ). Thus, we detected cytokine levels by ELISA and found that AECs possessed the ability to upregulate the concentrations of TNF‐ α , IL‐2, IL‐6, IL‐12, and IFN‐γ in splenocytes.…”

Cefazolin sodium pentahydrate cause urolithiasis: a case report and literature review

“…There are currently five generations of cephalosporins, mainly differentiated according to their structure, spectrum of activity and side-effect profile [ 1 ]. Cefazolin sodium pentahydrate, which belongs to the first generation of cephalosporin antibiotics, is an upgraded form of the traditional cefazolin sodium that further extends the strong anti-Gram-positive bacteria action of cefazolin sodium [ 2 ] and is suitable for the treatment of urinary tract, respiratory tract and biliary system infections. Previous studies have shown that cephalosporins such as ceftriaxone, cefotaxime and ceftazidime could induce urolithiasis [ 3–5 ].…”