Cefazolin encapsulated UIO-66-NH2 nanoparticles enhance the antibacterial activity and biofilm inhibition against drug-resistant S. aureus: In vitro and in vivo studies

Dastneshan, Amirhossein; Rahiminezhad, Shabnam; Mezajin, Maryam Naderi; Jevinani, Hoda Nouri; Akbarzadeh, Iman; Abdihaji, Mohammadreza; Qahremani, Reihane; Jahanbakhshi, Mehdi; Lalami, Zahra Asghari; Heydari, Hamid; Noorbazargan, Hassan; Mostafavi, Ebrahim

doi:10.1016/j.cej.2022.140544

Cited by 42 publications

(24 citation statements)

References 103 publications

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“…Because we treated the synthesized NPs with concentrated HCl to dissociate DA in the materials to afford the hierarchically porous NPs, it is not surprising that the MHP-UiO-66 NPs are resistant to the acidic conditions in the ALF. The cargo release profile of HP-UiO-66 NPs is consistent with the recently reported results for the release profiles for UiO-66 and UiO-66-NH 2 . , Interesting, Jarai et al found that their UiO-66 NPs with various defectiveness exhibited very different cargo release profiles in the PBS buffer and the ALF . The difference in cargo release performance of these UiO-66 NPs may be attributed to the different preparation methods and the difference in the interactions between the carriers and the cargo …”

Section: Resultssupporting

confidence: 87%

Pulmonary Delivery of Recombinant Human Bleomycin Hydrolase Using Mannose-Modified Hierarchically Porous UiO-66 for Preventing Bleomycin-Induced Pulmonary Fibrosis

Cui

Zhang

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Bleomycins (BLMs) are widely used in clinics as antitumor agents. However, BLM-based chemotherapies often accompany severe pulmonary fibrosis (PF). Human bleomycin hydrolase is a cysteine protease that can convert BLMs into inactive deamido-BLMs. In this study, mannose-modified hierarchically porous UiO-66 (MHP-UiO-66) nanoparticles (NPs) were used to encapsulate the recombinant human bleomycin hydrolase (rhBLMH). When rhBLMH@MHP-UiO-66 was intratracheally instilled into the lungs, the NPs were transported into the epithelial cells, and rhBLMH prevented the lungs from PF during BLM-based chemotherapies. Encapsulation of rhBLMH in the MHP-UiO-66 NPs protects the enzyme from proteolysis in physiological conditions and enhances cellular uptake. In addition, the MHP-UiO-66 NPs significantly enhance the pulmonary accumulation of intratracheally instilled rhBLMH, thus providing more efficient protection of the lungs against BLMs during the chemotherapies.

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Section: Resultssupporting

confidence: 87%

Pulmonary Delivery of Recombinant Human Bleomycin Hydrolase Using Mannose-Modified Hierarchically Porous UiO-66 for Preventing Bleomycin-Induced Pulmonary Fibrosis

Cui

Zhang

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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“…12,13,14,15 The combination of medicine and nanotechnology has modified multifunctional nanocarriers that can be loaded with different drugs. [15][16][17][18] Nanoparticle-based DDSs, such as liposomes, nanotubes, [19][20][21] metallic nanoparticles, 22,23 metal-organic frameworks, 24,25 mesoporous silica nanoparticles, 26 are promising carriers for targeted delivery due to their high surface area to mass ratio and high interaction which lead them to carry drug molecules efficiently rather than free drug molecules in solution. Moreover, these particles transfer their loaded active drug into cancer cells by selectively using tumors' peculiar stimuli.…”

Section: Introductionmentioning

confidence: 99%

In vitro Development of Controlled-Release Nanoniosomes for Improved Delivery and Anticancer Activity of Letrozole for Breast Cancer Treatment

Ahmadi¹,

Seraj²,

Chiani³

et al. 2022

IJN

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Introduction Breast cancer is among the most prevalent mortal cancers in women worldwide. In the present study, an optimum formulation of letrozole, letrozole-loaded niosome, and empty niosome was developed, and the anticancer effect was assessed in in vitro MCF-7, MCF10A and MDA-MB-231 breast cancer cell lines. Materials and Methods Various niosomal formulations of letrozole were fabricated through thin-film hydration method and characterized in terms of size, polydispersity index (PDI), morphology, entrapment efficiency (EE%), release kinetics, and stability. Optimized niosomal formulation of letrozole was achieved by response surface methodology (RSM). Antiproliferative activity and the mechanism were assessed by MTT assay, quantitative real-time PCR, and flow cytometry. Furthermore, cellular uptake of optimum formulation was evaluated by confocal electron microscopy. Results The formulated letrozole had a spherical shape and showed a slow-release profile of the drug after 72 h. The size, PDI, and eEE% of nanoparticles showed higher stability at 4°C compared with 25°C. The drug release from niosomes was in accordance with Korsmeyer–Peppa’s kinetic model. Confocal microscopy revealed the localization of drug-loaded niosomes in the cancer cells. MTT assay revealed that all samples exhibited dose-dependent cytotoxicity against breast cancer cells. The IC 50 of mixed formulation of letrozole with letrozole-loaded niosome (L + L 3 ) is the lowest value among all prepared formulations. L+L 3 influenced the gene expression in the tested breast cancer cell lines by down-regulating the expression of Bcl 2 gene while up-regulating the expression of p53 and Bax genes. The flow cytometry results revealed that L + L 3 enhanced the apoptosis rate in both MCF-7 and MDA-MB-231 cell lines compared with the letrozole (L), letrozole-loaded niosome (L 3 ), and control sample. Conclusion Results indicated that niosomes could be a promising drug carrier for the delivery of letrozole to breast cancer cells.

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“…Figure 2 shows the FT‐IR spectra of UiO‐66‐NH 2 and UiO‐66‐Pyr. For UiO‐66‐NH 2 , 484 and 565 cm −1 are the symmetric and asymmetric stretching of Zr‐(OC) [24] . 660 and 771 cm −1 are the transverse and longitudinal vibrations of Zr−O [25] .…”

Section: Resultsmentioning

confidence: 99%

“…For UiO-66-NH 2 , 484 and 565 cm À 1 are the symmetric and asymmetric stretching of Zr-(OC). [24] 660 and 771 cm À 1 are the transverse and longitudinal vibrations of ZrÀ O. [25] 1260 cm À 1 is the CÀ N stretching vibration.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

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Catalytic Hydrogenation of Furfural over UiO‐66‐NH₂‐derived Ru‐based Catalysts: Precursor Coordination Structure for Enhanced Catalysis

Zhu

Xia

et al. 2023

ChemistrySelect

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The −NH2 in UiO‐66‐NH2 was functionally modified with 2‐pyridinecarboxaldehyde to form Schiff base UiO‐66‐Pyr, and hollow nitrogen‐doped porous carbon‐ZrO2 supported Ru (Ru/NC‐ZrO2) was prepared from Ru3+‐coordinated UiO‐66‐Pyr‐Ru. Then the furfural hydrogenation performance of the product was investigated. Compared with single‐tooth‐coordinated UiO‐66‐NH2, the 2‐tooth‐coordinated UiO‐66‐Pyr can improve the stability of Ru3+ coordination and thereby increase the Ru loading and dispersity in the Ru/NC‐ZrO2, showing high furfural hydrogenation activity. The direct hydrogenation with hydrogen as the hydrogen source and the transfer hydrogenation with isopropanol as the hydrogen donor was determined by the furfural hydrogenation of Ru/NC‐ZrO2 under hydrogen or nitrogen.

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Cefazolin encapsulated UIO-66-NH2 nanoparticles enhance the antibacterial activity and biofilm inhibition against drug-resistant S. aureus: In vitro and in vivo studies

Cited by 42 publications

References 103 publications

Pulmonary Delivery of Recombinant Human Bleomycin Hydrolase Using Mannose-Modified Hierarchically Porous UiO-66 for Preventing Bleomycin-Induced Pulmonary Fibrosis

Pulmonary Delivery of Recombinant Human Bleomycin Hydrolase Using Mannose-Modified Hierarchically Porous UiO-66 for Preventing Bleomycin-Induced Pulmonary Fibrosis

In vitro Development of Controlled-Release Nanoniosomes for Improved Delivery and Anticancer Activity of Letrozole for Breast Cancer Treatment

Catalytic Hydrogenation of Furfural over UiO‐66‐NH₂‐derived Ru‐based Catalysts: Precursor Coordination Structure for Enhanced Catalysis

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Cefazolin encapsulated UIO-66-NH2 nanoparticles enhance the antibacterial activity and biofilm inhibition against drug-resistant S. aureus: In vitro and in vivo studies

Cited by 42 publications

References 103 publications

Pulmonary Delivery of Recombinant Human Bleomycin Hydrolase Using Mannose-Modified Hierarchically Porous UiO-66 for Preventing Bleomycin-Induced Pulmonary Fibrosis

Pulmonary Delivery of Recombinant Human Bleomycin Hydrolase Using Mannose-Modified Hierarchically Porous UiO-66 for Preventing Bleomycin-Induced Pulmonary Fibrosis

In vitro Development of Controlled-Release Nanoniosomes for Improved Delivery and Anticancer Activity of Letrozole for Breast Cancer Treatment

Catalytic Hydrogenation of Furfural over UiO‐66‐NH2‐derived Ru‐based Catalysts: Precursor Coordination Structure for Enhanced Catalysis

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Catalytic Hydrogenation of Furfural over UiO‐66‐NH₂‐derived Ru‐based Catalysts: Precursor Coordination Structure for Enhanced Catalysis