CEACAM1 distribution and it’s effects on angiogenesis and lymphangiogenesis in oral carcinoma

Zhou, Chengjun; Qu, Xun; Yang, Yongmei; Wang, Fufang; Dong, Zhao‐Ru; Wang, Cheng-Qin; Zhang, Xiaoying; Liu, Guixiang; Fang, Wei; Sun, Song

doi:10.1016/j.oraloncology.2009.03.002

Cited by 13 publications

(14 citation statements)

References 16 publications

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“…Immunohistochemistry results showed that CEACAM1 protein was mainly expressed on cytoplasm or membrane of tumor cells, which was consistent with previous research [30]. CEACAM1 expression in peritumoral tissues was negative or weak (Figure 1B a), whereas its expression was upregulated in cancer tissues (Figure 1B b) compared with peritumoral tissues ( P = 0.003).…”

Section: Resultssupporting

confidence: 91%

“…A series of studies have demonstrated that CEACAM1 can promote tumor progression and metastasis through many ways. For example, studies on oral squamous cell carcinoma [30] and non-small cell lung cancers [22] showed that CEACAM1 overexpression were associated with angiogenesis. Alireza Ebrahimnejad et al have demonstrated that CEACAM1 enhanced invasion and migration of melanocytic and melanoma cells [17].…”

Section: Discussionmentioning

confidence: 99%

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Neutrophils Infiltration in the Tongue Squamous Cell Carcinoma and Its Correlation with CEACAM1 Expression on Tumor Cells

et al. 2014

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ObjectiveThe present study aimed to explore the clinical significance of neutrophils infiltration and carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1) expression in the tongue squamous cell carcinoma (TSCC), and to probe the possible relationship between them.Materials and MethodsTissue microarray and immunohistochemistry were used to detect neutrophils density and CEACAM1 expression in 74 cases of primary TSCC specimens and 17 cases of corresponding peritumoral tissues. The relationship of CEACAM1 expression and neutrophils density with clinicopathologic parameters and cancer-related survival of TSCC patients were evaluated. The correlation between CEACAM1 expression and neutrophils density was also evaluated. Real-time quantitative transcription polymerase chain reaction (qRT-PCR) was used to explore the possible molecular mechanisms between CEACAM1 expression and neutrophils infiltration.ResultsImmunohistochemistry evaluation revealed that there was more neutrophils infiltration in TSCC tissues than in peritumoral tissues. High neutrophil density was associated with LN metastasis (P = 0.01), higher clinical stage (P = 0.037) and tumor recurrence (P = 0.024). CEACAM1 overexpression was also associated with lymph node metastasis (P = 0.000) and higher clinical stage (P = 0.001). Survival analysis revealed that both neutrophils infiltration and CEACAM1 overexpression were associated with poorer cancer-related survival of TSCC patients (P<0.05), and neutrophils infiltration was an independent prognostic factor for TSCC (P<0.05). Furthermore, overexpression of CEACAM1 was correlated with more neutrophils infiltration in TSCC tissues (P<0.01). qRT-PCR results showed that CEACAM1-4L can upregulate the mRNA expression of IL-8 and CXCL-6, which were strong chemotactic factors of neutrophils.ConclusionOur results demonstrated that more neutrophils infiltration and overexpression of CEACAM1 were associated with poor clinical outcomes in TSCC tissues. Overexpression of CEACAM1 on tumor cells correlated with more neutrophils infiltration to some extent through upregulating mRNA expression of IL-8 and CXCL-6.

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Section: Resultssupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Neutrophils Infiltration in the Tongue Squamous Cell Carcinoma and Its Correlation with CEACAM1 Expression on Tumor Cells

et al. 2014

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“…ZFAND4 expression was also associated with lymphatic involvement and hematogenous spread of tumour cells, further implicating it in metastasis. It is well known that angiogenesis and lymphangiogenesis strongly promote cancer metastasis 21. We have previously revealed that angiogenesis and lymphangiogenesis play a key role in the local progression, nodal metastasis and poor prognosis observed in patients with OSCC 6.…”

Section: Discussionmentioning

confidence: 96%

Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma

et al. 2017

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“…However, the role of CEACAM1 appears to be dependent of its distribution in oral squamous cell carcinoma. Zhou et al showed membranous CEACAM1 expression inhibits angiogenesis and lymphangiogenesis and is associated with well-differentiated SCC [ 88 ]. Conversely, cytoplasmic CEACAM1 expression, which is associated with poorly and moderately differentiated SCCs, promotes angiogenesis and lymphangiogenesis by mediating the transformation of vascular endothelial cells into lymphatic endothelial cells.…”

Section: Malignancies With Ceacam1 Overexpressionmentioning

confidence: 99%

On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies

Călinescu

Turcu

Nedelcu

et al. 2018

Journal of Immunology Research

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Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein belonging to the carcinoembryonic antigen (CEA) family that is expressed on a wide variety of cells and holds a complex role in inflammation through its alternate splicing and generation of various isoforms, mediating intricate mechanisms of modulation and dysregulation. Initially regarded as a tumor suppressor as its expression shows considerable downregulation within the epithelia in the early phases of many solid cancers, CEACAM1 has been linked lately to the progression of malignancy and metastatic spread as various papers point to its role in tumor progression, angiogenesis, and invasion. We reviewed the literature and discussed the various expression patterns of CEACAM1 in different types of tumors, describing its structure and general biologic functions and emphasizing the most significant findings that link this molecule to poor prognosis. The importance of understanding the role of CEACAM1 in cell transformation stands not only in this adhesion molecule's value as a prognostic factor but also in its promising premise as a potential new molecular target that could be exploited as a specific cancer therapy.

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CEACAM1 distribution and it’s effects on angiogenesis and lymphangiogenesis in oral carcinoma

Cited by 13 publications

References 16 publications

Neutrophils Infiltration in the Tongue Squamous Cell Carcinoma and Its Correlation with CEACAM1 Expression on Tumor Cells

Neutrophils Infiltration in the Tongue Squamous Cell Carcinoma and Its Correlation with CEACAM1 Expression on Tumor Cells

Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma

On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies

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