On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies

Călinescu, Andreea; Turcu, Gabriela; Nedelcu, Roxana Ioana; Brînzea, Alice; Hodorogea, Anastasia; Antohe, Mihaela; Diaconu, Carmen C.; Bleoţu, Coralia; Pirici, Daniel; Jilaveanu, Lucia B.; Ion, Daniela Adriana; Bădărău, Ioana Anca

doi:10.1155/2018/7169081

Cited by 29 publications

(26 citation statements)

References 77 publications

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“…CEACAM1 is expressed as a co-receptor on a variety of immune and parenchymal cell types as well on neoplastic and developing tissues with important functional implications. There are a number of excellent reviews on these topics [87][88][89][90]. Here we will focus on the role played by CEACAM1 in the immune system where it functions in both innate and adaptive immunity.…”

Section: Ceacam1 Modulates the Immune Responsementioning

confidence: 99%

CEACAM1 structure and function in immunity and its therapeutic implications

Kim

Huang

Gandhi

et al. 2019

Seminars in Immunology

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The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for tunable functions upon homophilic binding. CEACAM1 is highly expressed in the tumor environment and is strictly regulated on lymphocytes such that its expression is restricted to activated cells where it is now recognized to function in tolerance pathways. CEACAM1 is also an important target for microbes which have co-opted these attributes of CEACAM1 for the purposes of invading the host and evading the immune system. These properties, among others, have focused attention on CEACAM1 as a unique target for immunotherapy in autoimmunity and cancer. This review examines recent structural information derived from the characterization of CEACAM1:CEACAM1 interactions and heterophilic modes of binding especially to microbes and how this relates to CEACAM1 function. Through this, we aim to provide insights into targeting CEACAM1 for therapeutic intervention.

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Section: Ceacam1 Modulates the Immune Responsementioning

confidence: 99%

CEACAM1 structure and function in immunity and its therapeutic implications

Kim

Huang

Gandhi

et al. 2019

Seminars in Immunology

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“…CEACAM1 is a glycoprotein belonging to the carcinoembryonic antigen (CEA) family that is expressed in a wide variety of cells [32]. The prognostic value of CEACAM1 in cancer is controversial: CEACAM1 expression correlates with good prognosis in mammary carcinomas, whereas in melanomas, upregulation of CEACAM1 is accompanied by poor overall survival [33,34].…”

Section: Discussionmentioning

confidence: 99%

Cold Atmospheric Plasma Restores Paclitaxel Sensitivity to Paclitaxel-Resistant Breast Cancer Cells by Reversing Expression of Resistance-Related Genes

Park

Kim

et al. 2019

Cancers

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Paclitaxel (Tx) is a widely used therapeutic chemical for breast cancer treatment; however, cancer recurrence remains an obstacle for improved prognosis of cancer patients. In this study, cold atmospheric plasma (CAP) was tested for its potential to overcome the drug resistance. After developing Tx-resistant MCF-7 (MCF-7/TxR) breast cancer cells, CAP was applied to the cells, and its effect on the recovery of drug sensitivity was assessed in both cellular and molecular aspects. Sensitivity to Tx in the MCF-7/TxR cells was restored up to 73% by CAP. A comparison of genome-wide expression profiles between the TxR cells and the CAP-treated cells identified 49 genes that commonly appeared with significant changes. Notably, 20 genes, such as KIF13B, GOLM1, and TLE4, showed opposite expression profiles. The protein expression levels of selected genes, DAGLA and CEACAM1, were recovered to those of their parental cells by CAP. Taken together, CAP inhibited the growth of MCF-7/TxR cancer cells and recovered Tx sensitivity by resetting the expression of multiple drug resistance–related genes. These findings may contribute to extending the application of CAP to the treatment of TxR cancer.

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“…CEACAM1 as an important factor in carcinogenesis has dual roles of different isoforms [22]. For example, CEACAM-S isoform and CEACAM1-S/CEACAM1-L ratio were upregulated in non-small-cell lung cancer tissues [23], while CEACAM1-L isoforms in melanoma were upregulated [24].…”

Section: Discussionmentioning

confidence: 99%

Interferon gamma induces inflammatory responses through the interaction of CEACAM1 and PI3K in airway epithelial cells

Zhu

Song

et al. 2019

J Transl Med

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Background Interferon gamma (IFNγ) plays an important role in the development of chronic lung diseases via the production of inflammatory mediators, although the exact mechanism remains unclear. The present study aimed at investigating the potential mechanisms by which IFNγ induced over-production of interleukins through the interaction between carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) pathway. Methods IFN-γ induced over-production of interleukin (IL) 6 and IL8, and RNA expression of CEACAM1 and its subtypes or PI3K and its subtypes in human bronchial epithelial cells (HBE). The production of IL6 and IL8 or cell proliferation and movement were also evaluated in cell CEACAM1− or cell CEACAM1+ after the induction of IFN-γ. Roles of PI3K subtype proteins, e.g. PI3Kp110α/δ, Akt, p110α/γ/δ/β/mTOR, PI3Kp110α/δ/β, PI3Kp110δ, or pan-PI3K in IFN-γ-induced CEACAM1 subtype alterations were furthermore validated using those proteins of PI3K subtypes. Results CEACAM1, especially CEACAM1-S isoforms, was significantly up-regulated in HBE cells after treatment with IFN-γ. CEACAM1 played roles in expression of IL-6 and IL-8, and facilitated cellular proliferation and migration. IFN-γ up-regulated the expression of CEACAM1 in airway epithelial cells, especially CEACAM1-S isoforms, promoting cellular proliferation, migration, and the production of inflammatory factors. PI3K (p110δ)/Akt/mTOR pathway was involved in the process of IFN-γ-upregulated CEACAM1, especially CEACAM1-S. On the other hand, CEACAM1 could promote the activation of PI3K/Akt/mTOR pathway. Conclusion IFN-γ could induce inflammatory responses, cellular growth and proliferation through the interaction of CEACAM1 (especially CEACAM1-S isoforms) and PI3K(p110δ)/Akt/mTOR in airway epithelial cells, which might be new alternative of future therapies against epithelial transition from inflammation to cancer. Electronic supplementary material The online version of this article (10.1186/s12967-019-1894-3) contains supplementary material, which is available to authorized users.

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On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies

Cited by 29 publications

References 77 publications

CEACAM1 structure and function in immunity and its therapeutic implications

CEACAM1 structure and function in immunity and its therapeutic implications

Cold Atmospheric Plasma Restores Paclitaxel Sensitivity to Paclitaxel-Resistant Breast Cancer Cells by Reversing Expression of Resistance-Related Genes

Interferon gamma induces inflammatory responses through the interaction of CEACAM1 and PI3K in airway epithelial cells

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