CdS QDs-chitosan microcapsules with stimuli-responsive property generated by gas–liquid microfluidic technique

Chen, Yanjun; Yao, Rongyi; Wang, Yifeng; Chen, Ming; Qiu, Tong; Zhang, Chaocan

doi:10.1016/j.colsurfb.2014.11.001

Cited by 18 publications

(14 citation statements)

References 49 publications

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“…We found in our previous study that α‐CD can damage the shell of CS microcapsules through a strong host–guest interaction between hydrophobic cavities of the α‐CD and hydrophobic C 12 H 25 group tails of SDS. Therefore, the drugs embedded in two kinds of microcapsules were released faster in a 1.0 wt % α‐CD solution than in water.…”

Section: Resultsmentioning

confidence: 97%

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Mechanical properties and drug release of microcapsules containing quaternized‐chitosan‐modified reduced graphene oxide in the capsular wall

Xue

Chen

et al. 2016

J of Applied Polymer Sci

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Reduced graphene oxide (rGO) sheets were first modified with 2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC), and these modified rGO sheets (named HACC-rGO) were used as reinforcement materials and introduced to the walls of chitosan (CS) microcapsules. All of the monodisperse microcapsules were conveniently generated by a gas-liquid microfluidic technique. The results of scanning electron microscopy, X-ray diffraction, and thermogravimetric analysis all demonstrate that the HACC-rGO sheets existed and were dispersed in the capsular shell. The HACC-rGO-reinforced CS microcapsules showed better mechanical strength and better chemical stability with an a-cyclodextrin solution than the CS microcapsules without HACC-rGO. Importantly, the HACC-rGO-reinforced CS microcapsules exhibited a slower drug-release behavior and provide a method for the control of the release rate of drug-loaded microcapsules. In an in vitro cytotoxicity evaluation by a 3-(4,5-dimethyl-2-thiazolyl)-2,5diphenyl-2-H-tetrazolium bromide assay, the Schwann cells still showed good cell viability after they were treated by extracts of the CS/HACC-rGO microcapsules with concentrations ranging from 0.02 to 2000 lg/mL. Therefore, the HACC-rGO-reinforced CS microcapsules are promising for applications in the fields of drug delivery and controlled release. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44549.

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Section: Resultsmentioning

confidence: 97%

“…CS/HACC–rGO microcapsules were prepared in a gas–liquid microfluidic device that we designed. The square capillary with an inner diameter of 1 mm was matched with a cylindrical capillary with an outer diameter of 1 mm and an inner diameter of 600 µm (Zhong Cheng Quartz Glass Products Co., Ltd., Beijing China).…”

Section: Methodsmentioning

confidence: 99%

Mechanical properties and drug release of microcapsules containing quaternized‐chitosan‐modified reduced graphene oxide in the capsular wall

Xue

Chen

et al. 2016

J of Applied Polymer Sci

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“…The extra stable chitosan materials provide reliable quality of chitosan. The crucial environmental parameters like humidity and temperature alters physicochemical properties and applications of chitosan [22].…”

Section: Environmental Conditionsmentioning

confidence: 99%

Chitosan Formulations: Chemistry, Characteristics and Contextual Adsorption in Unambiguous Modernization of S&T

Dongre¹

2019

Hysteresis of Composites

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Since long scientists explored natural/bio-polymers to explicit their innate features to develop certain novel utilities in modernization of prevalent Science & Technology. Consequently biotope derived polysaccharide embrace huge prospective desired functions. Amid, chitosan, the second most ubiquitous polymer after cellulose exists as a β-(1-4)-linked d-glucosamine/N-acetyl-d-glucosamine randomly distributed linear polycationic yield from partial deacetylation of chitin polysaccharide. Chitin's complexity limits its extraction/insolubility in aqueous solution, thus less studied/research until 1980s. As major polysaccharides are either neutral/negatively charged in an acidic environment, instead chitosan is cationic, eventually forms electrostatic complexes/multilayer structures/composites with anionic synthetic dopants/natural polymers. Chitosan own biocompatibility, non-toxicity, low allergy and biodegradability allow utility as in water treatment, wound-healing, pharmaceutical excipient/drug carrier, obesity treatment and scaffold for tissue engineering. It is reflected in the increasing number of related publications throughout in biomedical, environmental and industrials applications. Feeble chitosan solubility limits their applications, yet benign synthetic techniques viz.; sol-gel, encapsulation, chemical grafting are employed to yield composites/ hydrogels/films/granules which generates new functionality, besides enhanced biocompatibility and biodegradability. This chapter presents the R&D, trends and the latest prospects involved in advance synthesis of chitosan supported composites/ hydrogels/films/granules/sheets with special highlighted pharmaceutical/biomedical and environmental applications.

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“…A biomarker indicator shows the measurement/valediction of biostate, organism survival, pathogenic process and therapeutic prime response, and supervises cancer stages, clinical screening prior to diagnosis, risk assessment and disease detection as well as staging, grading and initial treatment in auxiliary therapy [15,16]. Gold-coated chitosan/xanthan and graphene nanosphere-derived biomarkers are used for bioimaging, analysis in signal-improved melanoma cancer diagnoses, α-fetoprotein detection and carcinoembryonic antigen discovery, and are more accurate than electrochemical sensors and the ELISA test [17,18]. Chitosan biomarkers are preferred for their due-advantage services in disease prevention, drug/tissue/ cell delivery, dentistry, orthopaedics, ophthalmology, surgery and as an optical-wave guide, as shown in Figure 4.…”

Section: Biosensor/biomarkermentioning

confidence: 99%

“…Chitosan-doped cysteine/cadmium/tellurium quantum dots are favoured over counter-immune sensors for their antibacterial profile, electrochemical/ luminescent offender DNA biosensing in chronic myelogenous leukemia, antibody immobility and specific protein detection [2-11, 13-17, 19]. Chitosan-formatted quantum dots are quick to generate safe/effectual delivery, silence unwanted gene expression/defects in curing diseases and can deliver genetic plasmids, DNA, si-RNA and oligonucleotides [13][14][15][16][17][18][19][20]. Nanometal-homogenized chitosan quantum dots offer controlled catalytic activity for multiple site selective gaseous adsorption/desorption [20,21].…”

Section: Chitosan-based Quantum Dotmentioning

confidence: 99%

Introductory Chapter: Multitask Portfolio of Chitin/Chitosan: Biomatrix to Quantum Dot

Dongre¹

2018

Chitin-Chitosan - Myriad Functionalities in Science and Technology

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CdS QDs-chitosan microcapsules with stimuli-responsive property generated by gas–liquid microfluidic technique

Cited by 18 publications

References 49 publications

Mechanical properties and drug release of microcapsules containing quaternized‐chitosan‐modified reduced graphene oxide in the capsular wall

Mechanical properties and drug release of microcapsules containing quaternized‐chitosan‐modified reduced graphene oxide in the capsular wall

Chitosan Formulations: Chemistry, Characteristics and Contextual Adsorption in Unambiguous Modernization of S&T

Introductory Chapter: Multitask Portfolio of Chitin/Chitosan: Biomatrix to Quantum Dot

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