Cdk5 Phosphorylation of ErbB4 is Required for Tangential Migration of Cortical Interneurons

Rakić, Sonja; Kanatani, Shigeaki; Hunt, David; Faux, Clare; Cariboni, Anna; Chiara, Francesca; Khan, Shabana; Wansbury, Olivia; Howard, Beatrice A.; Nakajima, Kazunori; Nikolic, Margareta; Parnavelas, John G.

doi:10.1093/cercor/bht290

Cited by 31 publications

(27 citation statements)

References 51 publications

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“…For example, Rakic and colleagues beautifully demonstrated that MGE-cells are able to migrate towards three ErbB4 ligands, which are extensively expressed in vivo by non-interneurons of the developing forebrain [28]. …”

Section: How To Study Neuronal Migration In the Cerebral Cortexmentioning

confidence: 99%

In Vitro, Ex Vivo and In Vivo Techniques to Study Neuronal Migration in the Developing Cerebral Cortex

et al. 2017

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Neuronal migration is a fundamental biological process that underlies proper brain development and neuronal circuit formation. In the developing cerebral cortex, distinct neuronal populations, producing excitatory, inhibitory and modulatory neurotransmitters, are generated in different germinative areas and migrate along various routes to reach their final positions within the cortex. Different technical approaches and experimental models have been adopted to study the mechanisms regulating neuronal migration in the cortex. In this review, we will discuss the most common in vitro, ex vivo and in vivo techniques to visualize and study cortical neuronal migration.

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Section: How To Study Neuronal Migration In the Cerebral Cortexmentioning

confidence: 99%

In Vitro, Ex Vivo and In Vivo Techniques to Study Neuronal Migration in the Developing Cerebral Cortex

et al. 2017

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“…A recent study further revealed that Cdk5-mediated phosphorylation of receptor tyrosine-protein kinase erbB-4 (ErbB4) at Tyr1056, a docking site for PI3-kinase, is necessary for tangential migration of interneurons both toward and within the cerebral cortex [66] (Table 1). Importantly, phosphorylated ErbB4 reside in close proximity to MTs in adult interneurons, suggesting that Cdk5-directed migration of cortical interneurons likely occurs through MT cytoskeletal remodeling.…”

Section: Role Of Cdk5 In Neuronal Migrationmentioning

confidence: 99%

A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5

Shah

Lahiri

2016

Mol Neurobiol

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Cdk5, a cyclin dependent kinase family member, is a global orchestrator of neuronal cytoskeletal dynamics. During embryogenesis, Cdk5 is indispensable for brain development. In adults, it is essential for numerous neuronal processes, including higher cognitive functions such as learning and memory formation, drug addiction, pain signaling and long term behavior changes through long term potentiation and long term depression, all of which rely on rapid alterations in the cytoskeleton. Cdk5 activity becomes deregulated in various brain disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, attention-deficit hyperactivity disorder, epilepsy, schizophrenia and ischemic stroke; these all result in profound remodeling of the neuronal cytoskeleton. This Commentary specifically focuses on the pleiotropic contribution of Cdk5 in regulating neuronal microtubule remodeling. Because the vast majority of the physiological substrates of Cdk5 are associated with the neuronal cytoskeleton, our emphasis is on the Cdk5 substrates, such as CRMP2, stathmin, drebrin, dixdc1, axin, GKAP, kinesin-5, tau and PSD-95, that have allowed to unravel the molecular mechanisms through which Cdk5 exerts its divergent roles in regulating neuronal microtubule dynamics, both in healthy and disease states.

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“…The cortical migration of GABAergic interneurons (Guo and Anton, ) occurs at a different mode and is regulated by different mechanisms of microtubule modulation (Eom et al, ). However, these do share some fundamental features with projection neurons, such as the requirement for N‐cadherin (Luccardini et al, ) and CDK5 activity (Rakić et al, , ). An interesting emerging realization pertaining to cortical interneuron migration is the role of signaling from the primary cilium (Baudoin et al, ; Métin and Pedraza, ).…”

Section: Roles Of Other Members Of the Small Gtpase Family In Neuron mentioning

confidence: 99%

Rab, Arf, and Arl-Regulated Membrane Traffic in Cortical Neuron Migration

Tang

2015

J. Cell. Physiol

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The migration of projection neurons from its birthplace in the subventricular zone to their final destination in the cortical plate is a complex process that requires a series of highly coordinated cellular events. Amongst the key factors involved in the processes are modulators of cytoskeletal dynamics, as well as cellular membrane traffic. Members of the small GTPases family responsible for the latter process, the Rabs and Arfs, have been recently implicated in cortical neuron migration. Rab5 and Rab11, which are key modulators of endocytosis and endocytic recycling respectively, ensure proper surface expression and distribution of N-cadherin, a key adhesion protein that tethers migrating neurons to the radial glia fiber tracts during pia-directed migration. Rab7, which is associated with lysosomal biogenesis and function, is important for the final step of terminal translocation when N-cadherin is downregulated by lysosomal degradation. Arf6 activity, which is known to be important in neuronal processes outgrowth, may negatively impact the multipolar-bipolar transition of cortical neurons undergoing radial migration, but the downstream effector of Arf6 in this regard is not yet known. In addition to the above, members of the Arl family which have been recently shown to be important in radial glia scaffold formation, would also be important for cortical neuron migration. In this short review, we discuss recent advances in our understanding of the importance of membrane traffic regulated by the Rab, Arf, and Arl family members in cortical neuron migration.

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Cdk5 Phosphorylation of ErbB4 is Required for Tangential Migration of Cortical Interneurons

Cited by 31 publications

References 51 publications

In Vitro, Ex Vivo and In Vivo Techniques to Study Neuronal Migration in the Developing Cerebral Cortex

In Vitro, Ex Vivo and In Vivo Techniques to Study Neuronal Migration in the Developing Cerebral Cortex

A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5

Rab, Arf, and Arl-Regulated Membrane Traffic in Cortical Neuron Migration

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