CDK regulators—Cell cycle progression or apoptosis—Scenarios in normal cells and cancerous cells

Nilmani,; D'costa, Maria; Bothe, Anusha; Das, Soumik; Kumar, Shashank; Gnanasambandan, R.; Doss, C. George Priya

doi:10.1016/bs.apcsb.2022.11.008

Cited by 14 publications

(14 citation statements)

References 188 publications

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“…It is necessary to point out that R‐X‐X‐Ps, the only basic motif is a target of CaMK II, which may have a significant role in the NSCs. It has been reported that CaMK II is involved in synaptic transmission, plasticity and NSCs differentiation 40,41 …”

Section: Resultsmentioning

confidence: 99%

“…It has been reported that CaMK II is involved in synaptic transmission, plasticity and NSCs differentiation. 40 , 41 …”

Section: Resultsmentioning

confidence: 99%

“…It has been reported that CaMK II is involved in synaptic transmission, plasticity and NSCs differentiation. 40,41 Sequentially, we compared motifs in two groups with score profiles to reveal the changes in RA-induced differentiation (Figure 3B,C). However, the CK2-related phosphosites with motif pSDED, pSDX[D/E] and pSEXE showed no significant different between self-renewal and RA-induced group, indicating that CK2 played a crucial role in growth of stem cell but unrelated with RA.…”

Section: Conserved Phosphorylation Motif Analysis Of the Phosphorylat...mentioning

confidence: 99%

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Retinoic acid induced specific changes in the phosphoproteome of C17.2 neural stem cells

Zhang,

Ge,

Xie

et al. 2024

J Cellular Molecular Medi

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Retinoic acid (RA), a vitamin A derivative, is an effective cell differentiating factor which plays critical roles in neuronal differentiation induction and the production of neurotransmitters in neurons. However, the specific changes in phosphorylation levels and downstream signalling pathways associated with RA remain unclear. This study employed qualitative and quantitative phosphoproteomics approaches based on mass spectrometry to investigate the phosphorylation changes induced by RA in C17.2 neural stem cells (NSCs). Dimethyl labelling, in conjunction with TiO2 phosphopeptide enrichment, was utilized to profile the phosphoproteome of self‐renewing and RA‐induced differentiated cells in C17.2 NSCs. The results of our study revealed that, qualitatively, 230 and 14 phosphoproteins were exclusively identified in the self‐renewal and RA‐induced groups respectively. Quantitatively, we successfully identified and quantified 177 unique phosphoproteins, among which 70 exhibited differential phosphorylation levels. Analysis of conserved phosphorylation motifs demonstrated enrichment of motifs corresponding to cyclin‐dependent kinase and MAPK in the RA‐induced group. Additionally, through a comprehensive literature and database survey, we found that the differentially expressed proteins were associated with the Wnt/β‐catenin and Hippo signalling pathways. This work sheds light on the changes in phosphorylation levels induced by RA in C17.2 NSCs, thereby expanding our understanding of the molecular mechanisms underlying RA‐induced neuronal differentiation.

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Section: Resultsmentioning

confidence: 99%

“…It has been reported that CaMK II is involved in synaptic transmission, plasticity and NSCs differentiation. 40 , 41 …”

Section: Resultsmentioning

confidence: 99%

Section: Conserved Phosphorylation Motif Analysis Of the Phosphorylat...mentioning

confidence: 99%

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Retinoic acid induced specific changes in the phosphoproteome of C17.2 neural stem cells

Zhang,

Ge,

Xie

et al. 2024

J Cellular Molecular Medi

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“…Therefore, tumours are caused by aberrant cell proliferation due to disruptions in cell cycle regulation 3. The CKS family comprises a group of small proteins that play important roles in regulating the cell division cycle 6. Both CKS1 and CKS2 are reportedly involved in regulating cell proliferation, playing distinct roles in different cell cycle phases 30.…”

Section: Discussionmentioning

confidence: 99%

“…Among them, CDK subunit 2 (CKS2) has emerged as a protein of significant interest due to its critical involvement in the G2/M transition of the cell cycle 5. Beyond its role in cell cycle regulation, CKS2 is implicated in various physiological processes, including mitosis, cellular differentiation and cell proliferation 6. This multifaceted involvement underscores the potential of CKS2 as a key player in cancer pathophysiology.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of cyclin-dependent kinase subunit 2 (CKS2) in malignant tumours: a meta-analysis and bioinformatic analysis

Zhang,

Li,

Huang

et al. 2024

BMJ Open

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ObjectivesThis study aimed to systematically elucidate the prognostic significance of cyclin-dependent kinase subunit 2 (CKS2) expression in various cancers and its correlation with their clinicopathological characteristics.DesignIn this meta-analysis and bioinformatic analysis, articles were identified through searches of multiple databases and meta-analysed according to the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols. Data from The Cancer Genome Atlas were examined using UCSC Xena tools to further confirm the prognostic effect of CKS2.Data sourcesThe PubMed, Embase, Web of Science and Cochrane Library databases were searched for articles published from their inception to 1 January 2023, using a combination of subject terms and free words, including ‘CKS2’, ‘cancer’, ‘tumor’, ‘neoplasm’, ‘carcinoma’, ‘malignancy’ and ‘prognosis’.Eligibility criteriaThe analysis included cohort or case–control studies, reported in English, with malignancy diagnoses confirmed by pathological methods, available HRs and 95% CIs for overall survival (OS) or extractable Kaplan-Meier curves, and a sample size of ≥20 patients. Reviews, commentaries, letters, conference reports, case reports, in vitro and animal studies, studies ofCKS2gene variants, studies with sample cases from public databases and studies with unavailable survival or duplicated data were excluded.Data extraction and synthesisTwo researchers independently screened the articles, extracted the data and evaluated the quality of included studies using the Newcastle-Ottawa Scale. Meta-analysis and bioinformatic analyses were performed using the STATA and R software, respectively.ResultsThe analysis included 13 retrospective studies encompassing 1348 cases across 10 cancer types. Nine studies involving 1124 patients examined the correlation between CKS2 expression levels and OS. A fixed-effects model analysis revealed a significant association between high CKS2 expression and reduced OS (HR=2.27, 95% CI=1.87 to 2.77, p<0.001). Furthermore, high CKS2 expression was significantly associated with advanced tumour stage (relative risk (RR) = 1.82, 95% CI=1.57 to 2.11, p<0.001), lymph node metastasis (RR=1.68, 95% CI=1.38 to 2.04, p<0.001), larger tumour size (RR=1.60, 95% CI=1.27 to 2.03, p<0.001) and lower differentiation grade (RR=1.57, 95% CI=1.29 to 1.90, p<0.001). CKS2 expression levels were not significantly correlated with patients’ age (RR=1.11, 95% CI=0.99 to 1.26, p=0.071) or sex (RR=0.98, 95% CI=0.90 to 1.07, p=0.653). An assessment of the articles showed no significant publication bias, confirming the robustness of these findings. The bioinformatic analysis further confirmed CKS2 upregulation in the examined cancer types and its association with poor OS in glioma (HR=1.97, 95% CI=1.78 to 2.18, p=3.70×10−42), liver hepatocellular carcinoma (HR=1.56, 95% CI=1.31 to 1.86, p=3.50×10−7) and lung adenocarcinoma (HR=1.27, 95% CI=1.10 to 1.48, p=1.70×10−3).ConclusionsElevated CKS2 expression is associated with poor prognosis in a subset of malignant tumours, highlighting its potential as a prognostic marker.PROSPERO registration numberCRD42023394038.

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Immunohistochemical Expression of Cyclin D1 and p16 in Invasive Breast Carcinoma and Its Association with Clinicopathological Parameters

Malik,

V.,

Ahuja

et al. 2024

Indian J Surg Oncol

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CDK regulators—Cell cycle progression or apoptosis—Scenarios in normal cells and cancerous cells

Cited by 14 publications

References 188 publications

Retinoic acid induced specific changes in the phosphoproteome of C17.2 neural stem cells

Retinoic acid induced specific changes in the phosphoproteome of C17.2 neural stem cells

Prognostic significance of cyclin-dependent kinase subunit 2 (CKS2) in malignant tumours: a meta-analysis and bioinformatic analysis

Immunohistochemical Expression of Cyclin D1 and p16 in Invasive Breast Carcinoma and Its Association with Clinicopathological Parameters

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