CDC Grand Rounds: Prevention and Control of Skin Cancer

Abstract

Skin cancer is the most common cancer in the United States, and most cases are preventable. Persons with certain genetic risk factors, including having a lighter natural skin color; blue or green eyes; red or blonde hair; dysplastic nevi or a large number of common moles; and skin that burns, freckles, or reddens easily or becomes painful after time in the sun, have increased risk for skin cancer. Persons with a family or personal history of skin cancer, especially melanoma, are also at increased risk. Although these genetic factors contribute to individual risk, most skin cancers are also strongly associated with ultraviolet (UV) radiation exposure. Most UV exposure comes from the sun, although some persons use UV-emitting indoor tanning devices (e.g., beds, booths, and lamps).

Trends in cancer mortality among people with vs without diabetes in the USA, 1988–2015

“…Relative mortality reductions in total cancer, colorectal cancer and melanoma were similar in adults with and without diabetes. This finding may reflect populationwide reductions in exposure to risk factors such as smoking [28] and ultraviolet light [29], as well as the impact of national screening programmes [30] and therapeutic advances [31]. For pancreas and breast cancers, relative declines were greater for adults with than without diabetes.…”

Zinc oxide nanoparticles synthesized from Allium cepa prevents UVB radiation mediated inflammation in human epidermal keratinocytes (HaCaT cells)

“…Our records also exposed that the form of cell death was apoptosis which was arbitrated by the ROS simultaneously activates mitochondrial pathway as confirmation by a reduction in MMP, the inflection of Bax/Bcl2 ratio and breakage in cascade molecules like Caspase-9&3. ZnO-NPs were accounted to be generally less effective at low concentrations in HaCaT and mouse embryonic fibroblasts cells but displayed improved shielding competence with rising concentrations [32].…”

Investigating skin age analysis to reduce tanning intentions among adolescents: A pilot study

“…Adolescents are at high risk for deliberate ultraviolet (UV) exposure; thus, it is imperative to identify adequate skin cancer prevention strategies targeting this age group. [1][2][3] Here, we introduce the use of skin age analysis combined with UV photography as a novel intervention to reduce tanning intentions in an adolescent population.…”