CD9 Is a Novel Target in Glomerular Diseases Typified by Parietal Epithelial Cell Activation

Smeets, Bart; Miesen, Laura; Shankland, Stuart J.

doi:10.1053/j.ajkd.2019.08.012

Cited by 4 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…125 As a tetraspanin, CD9 has four transmembrane domains and regulates various cellular processes through formation of tetraspanin-enriched microdomains, spatially regulating function of adhesion receptors, growth factor receptors, and more. 126,127 According to Lazareth et al , CD9 is expressed de novo in PECs during crescentic GN in both mice and humans. Temporally, Cd9 was induced early in crescentic GN and before induction of Cd44 .…”

Section: Molecular Determinants Of Pec Activationmentioning

confidence: 99%

See 1 more Smart Citation

Podocyte-Parietal Epithelial Cell Interdependence in Glomerular Development and Disease

Bronstein

Pace

Gowthaman

et al. 2023

JASN

View full text Add to dashboard Cite

Podocytes and parietal epithelial cells (PECs) are among the few principal cell types within the kidney glomerulus, the former serving as a crucial constituent of the kidney filtration barrier and the latter representing a supporting epithelial layer that adorns the inner wall of Bowman's capsule. Podocytes and PECs share a circumscript developmental lineage that only begins to diverge during the S-shaped body stage of nephron formation–occurring immediately before the emergence of the fully mature nephron. These two cell types, therefore, share a highly conserved gene expression program, evidenced by recently discovered intermediate cell types occupying a distinct spatiotemporal gene expression zone between podocytes and PECs. In addition to their homeostatic functions, podocytes and PECs also have roles in kidney pathogenesis. Rapid podocyte loss in diseases, such as rapidly progressive GN and collapsing and cellular subtypes of FSGS, is closely allied with PEC proliferation and migration toward the capillary tuft, resulting in the formation of crescents and pseudocrescents. PECs are thought to contribute to disease progression and severity, and the interdependence between these two cell types during development and in various manifestations of kidney pathology is the primary focus of this review.

show abstract

Section: Molecular Determinants Of Pec Activationmentioning

confidence: 99%

“…126,127 According to Lazareth et al, CD9 is expressed de novo in PECs during crescentic GN in both mice and humans.…”

mentioning

confidence: 99%

Podocyte-Parietal Epithelial Cell Interdependence in Glomerular Development and Disease

Bronstein

Pace

Gowthaman

et al. 2023

JASN

View full text Add to dashboard Cite

show abstract

“…Recently, CD9 has been proven to promote the migration of PECs into the glomerular tuft, where they acquire CD44 and β1 integrin expression ( Lazareth et al, 2019 ; Smeets et al, 2020 ). However, these potential candidate pathways require further convincing evidence.…”

Section: Signaling Pathways Regulate Parietal Epithelial Cell Activat...mentioning

confidence: 99%

The Role of Parietal Epithelial Cells in the Pathogenesis of Podocytopathy

Guo

Quan

et al. 2022

Front. Physiol.

View full text Add to dashboard Cite

Podocytopathy is the most common feature of glomerular disorder characterized by podocyte injury- or dysfunction-induced excessive proteinuria, which ultimately develops into glomerulosclerosis and results in persistent loss of renal function. Due to the lack of self-renewal ability of podocytes, mild podocyte depletion triggers replacement and repair processes mostly driven by stem cells or resident parietal epithelial cells (PECs). In contrast, when podocyte recovery fails, activated PECs contribute to the establishment of glomerular lesions. Increasing evidence suggests that PECs, more than just bystanders, have a crucial role in various podocytopathies, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, diabetic nephropathy, IgA nephropathy, and lupus podocytopathy. In this review, we attempt to dissect the diverse role of PECs in the pathogenesis of podocytopathy based on currently available information.

show abstract

Novel therapeutic perspectives for crescentic glomerulonephritis through targeting parietal epithelial cell activation and proliferation

Huang

Zhao

Zhang

et al. 2023

Expert Opinion on Therapeutic Targets

View full text Add to dashboard Cite

CD9 Is a Novel Target in Glomerular Diseases Typified by Parietal Epithelial Cell Activation

Cited by 4 publications

References 18 publications

Podocyte-Parietal Epithelial Cell Interdependence in Glomerular Development and Disease

Podocyte-Parietal Epithelial Cell Interdependence in Glomerular Development and Disease

The Role of Parietal Epithelial Cells in the Pathogenesis of Podocytopathy

Novel therapeutic perspectives for crescentic glomerulonephritis through targeting parietal epithelial cell activation and proliferation

Contact Info

Product

Resources

About