CD8+ T cells: The past and future of immune regulation

Lees, Jason R.

doi:10.1016/j.cellimm.2020.104212

Cited by 24 publications

(17 citation statements)

References 129 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CD8 + T effectors were the major subtype of CD8 + T cells to exert anti-tumor. CD8 + T effectors can be used to estimate the patients’ response to immunotherapy ( Lees, 2020 ). The immune checkpoint inhibitor score (IMS) scoring system based on CD8 + T effector and immune checkpoint signatures can better predict the response to immunotherapy and can estimate the prognosis of patients with bladder cancer ( Chen et al, 2021b ).…”

Section: Discussionmentioning

confidence: 99%

Generation and Analysis of Pyroptosis-Based and Immune-Based Signatures for Kidney Renal Clear Cell Carcinoma Patients, and Cell Experiment

et al. 2022

View full text Add to dashboard Cite

Background: Pyroptosis is a programmed cell death caused by inflammasomes, which is closely related to immune responses and tumor progression. The present study aimed to construct dual prognostic indices based on pyroptosis-associated and immune-associated genes and to investigate the impact of the biological signatures of these genes on Kidney Renal Clear Cell Carcinoma (KIRC).Materials and Methods: All the KIRC samples from the Cancer Genome Atlas (TCGA) were randomly and equally divided into the training and testing datasets. Cox and Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis were used to screen crucial pyroptosis-associated genes (PAGs), and a pyroptosis-associated genes prognostic index (PAGsPI) was constructed. Immune-associated genes (IAGs) related to PAGs were identified, and then screened through Cox and LASSO regression analyses, and an immune-associated genes prognostic index (IAGsPI) was developed. These two prognostic indices were verified by using the testing and the Gene Expression Omnibus (GEO) datasets and an independent cohort. The patients’ response to immunotherapy was analyzed. A nomogram was constructed and calibrated. qRT-PCR was used to detect the expression of PAGs and IAGs in the tumor tissues and normal tissues. Functional experiment was carried out.Results: 86 PAGs and 1,774 differentially expressed genes (DEGs) were obtained. After intersecting PAGs with DEGs, 22 differentially expressed PAGs (DEPAGs) were included in Cox and LASSO regression analyses, identifying 5 crucial PAGs. The PAGsPI was generated. Patients in the high-PAGsPI group had a poor prognosis. 82 differentially expressed IAGs (DEIAGs) were highly correlated with DEPAGs. 7 key IAGs were screened out, and an IAGsPI was generated. Patients in the high-IAGsPI group had a poor prognosis. PAGsPI and IAGsPI were verified to be robust and reliable. The results revealed patients in low-PAGsPI group and high-IAGsPI group may be more sensitive to immunotherapy. The calibrated nomogram was proved to be reliable. An independent cohort study also proved that PAGsPI and IAGsPI performed well in prognosis prediction. We found that the expression of AIM2 may affect proliferation of KIRC cells.Conclusion: PAGsPI and IAGsPI could be regarded as potential biomarkers for predicting the prognosis of patients with KIRC.

show abstract

Section: Discussionmentioning

confidence: 99%

Generation and Analysis of Pyroptosis-Based and Immune-Based Signatures for Kidney Renal Clear Cell Carcinoma Patients, and Cell Experiment

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Elevated expression of HLA molecules and a high fraction of leukocyte cells in the C1 subtype might arise in better immunotherapeutic response and more curative benefits. The CD8+ T cells are the main force and direct effectors to fight against tumors ( 37 , 38 ). The CD4+ T cells work as helpers to activate CD8+ T cells, enhancing antitumor performance ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Necroptosis throws novel insights on patient classification and treatment strategies for hepatocellular carcinoma

Gao

Shi

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

IntroductionNecroptosis is a novel pattern of immunogenic cell death and has triggered an emerging wave in antitumor therapy. More evidence has suggested the potential associations between necroptosis and intra-tumoral heterogeneity. Currently, the underlying role of necroptosis remains elusive in hepatocellular carcinoma (HCC) at antitumor immunity and inter-tumoral heterogeneity.MethodsThis study enrolled a total of 728 HCC patients and 139 immunotherapy patients from eight public datasets. The consensus clustering approach was employed to depict tumor heterogeneity of cancer necroptosis. Subsequently, our study further decoded the heterogeneous clinical outcomes, genomic landscape, biological behaviors, and immune characteristics in necroptosis subtypes. For each patient, providing curative clinical recommendations and developing potential therapeutic drugs were used to promote precise medicine.ResultsWith the use of the weighted gene coexpression network analysis (WGCNA) algorithm, necroptosis-associated long non-coding RNAs (lncRNAs) (NALRs) were identified in HCC. Based on the NALR expression, two heterogeneous subtypes were decoded with distinct clinical outcomes. Compared to patients in C1, patients in C2 harbored superior pathological stage and presented more unfavorable overall survival and recurrence-free survival. Then, the robustness and reproducibility of necroptosis subtypes were further validated via the nearest template prediction (NTP) approach and classical immune phenotypes. Through comprehensive explorations, C1 was characterized by enriched immune-inflammatory and abundant immune infiltration, while C2 possessed elevated proliferative and metabolic activities and highly genomic instability. Moreover, our results indicated that C1 was more prone to obtain desirable benefits from immunotherapy. For patients in C2, numerous underlying therapeutic agents were developed, which might produce significant efficacy.ConclusionThis study identified two necroptosis subtypes with distinct characteristics, decoding the tumor heterogeneity. For an individualized patient, our work tailored corresponding treatment strategies to improve clinical management.

show abstract

“…Therefore, while CTLs may reach irradiated primary tumor cells more readily, metastatic sites are far less accessible, thus limiting abscopal tumor remission. Effective tumor cell lysis is achieved by recognition of neoantigen by CTLs and cell killing via cytotoxic degranulation or induction of tumor cell apoptosis (42). However, evidence suggests that oftentimes, tumor cell surface expression of the inhibitory signal molecules PD-1, PD-L1, and CTLA-4 potently counteracts this process (43,44).…”

Section: The Abscopal Effect Is An Antitumor Immune Responsementioning

confidence: 99%