2017
DOI: 10.4049/jimmunol.1700982
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CD8+ T Cells Prevent Lethality from Neonatal Murine Roseolovirus Infection

Abstract: A recently described mouse homolog of the human roseoloviruses, murine roseolovirus (MRV), causes loss of peripheral and thymic CD4+ cells during neonatal infection of BALB/c mice. Despite significant disruptions to the normal adaptive immune response, infected BALB/c mice reproducibly recover from infection, consistent with prior studies on a related virus, mouse thymic virus (MTV). Herein we show that in contrast to published studies on MTV, MRV appears to robustly infect neonatal C57BL/6 (B6) mice causing s… Show more

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Cited by 5 publications
(25 citation statements)
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“…This appears to be a polyclonal and antigen restricted response [163]. Supporting an important role of CD8 + T cells in controlling MRV infection, CD8 knockout mice are unable to recover CD4 + T cell levels and have an 80% mortality after neonatal infection [163]. Of note, this demonstrates that CD4 + T cell depletion occurs independently of CD8 + T cells.…”
Section: Immune Response and Antiviral Drugsmentioning
confidence: 93%
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“…This appears to be a polyclonal and antigen restricted response [163]. Supporting an important role of CD8 + T cells in controlling MRV infection, CD8 knockout mice are unable to recover CD4 + T cell levels and have an 80% mortality after neonatal infection [163]. Of note, this demonstrates that CD4 + T cell depletion occurs independently of CD8 + T cells.…”
Section: Immune Response and Antiviral Drugsmentioning
confidence: 93%
“…Transient necrosis of the lymph nodes and spleen also occur in MRV inoculated neonatal mice, which starts at day 7 and peaks at 14 dpi [161]. In these infected lymphoid organs, lymphocytes, epithelial reticular cells, macrophages, and thymic nurse cells contain viral particles and filamentous structures in both the nucleus and the cytoplasm [162,163]. By three weeks post-inoculation (wpi), the histology of the infected thymus becomes normal again [160], and the total number of cells in the mesenteric lymph node is recovered to the levels of normal mice [161].…”
Section: Pathogenicitymentioning
confidence: 99%
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