CD8+, CD4+ and FOXP3+ cell profiles and their change after neoadjuvant chemotherapy in patients with triple negative breast cancer

Verovkina, N. O.; Lyalkin, S.; Syvak, L.А.; Askolskyi, A.; Majdanevych, N M

doi:10.1093/annonc/mdy271.267

Cited by 2 publications

(2 citation statements)

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“…Mutations in the expression of the Foxp3 gene have been associated with tumorigenic activity [29,30]. The Tregulator cell Foxp3 has also emerged as a prognostic biomarker in breast cancer and its response to chemotherapy [31][32][33][34][35].…”

Section: Stress Sel Tregulator and Breast Cancermentioning

confidence: 99%

Massage on the prevention of breast cancer through stress reduction and enhancing immune system

Siregar,

Usman,

Ahmad

et al. 2024

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INTRODUCTION: Housewives are a population at high risk of breast cancer due to repeated or chronic exposure to stress. Prevention in a simple yet evidence-based manner is needed. METHODS: This study is a narrative review of the potential of massage as breast cancer prevention through stress and immune system mechanisms. RESULTS: Massage is able to prevent chronic stress through improved sleep and fatigue and lower stress levels. Prevention of chronic stress will maximize the function of cells that eliminate cancer cells, such as B cells, T cells, and natural killer (NK) cells, and improve the balance of Foxp3 Tregulator cells. Partnered delivery massage will bring effective benefits for stress reduction. CONCLUSIONS: Massage can provide indirect prevention of breast cancer, and partnered delivery massage can be a good choice to reduce stress.

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Section: Stress Sel Tregulator and Breast Cancermentioning

confidence: 99%

Massage on the prevention of breast cancer through stress reduction and enhancing immune system

Siregar,

Usman,

Ahmad

et al. 2024

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“…To be more specific, Ladoire et al ( 181 ) and Senovilla et al ( 182 ) found that, in patients treated with NAC, it is the increased CTL/Treg cell ratio in TME that can precisely predict pCR. Interestingly, the levels of CD8+ T cells and Tregs decreased during NAC in patients of TNBC ( 183 ), which raise a question of whether the dynamics of Treg can predict pCR. Hamy et al ( 179 ) found that the decrease of lymphocyte infiltration during chemotherapy is related to the increase of PCR rate, which may be related to the disappearance of Treg after neoadjuvant therapy, but there are few related studies.…”

Section: The Correlation Between Tregs and Different Therapeutic Strategies Of Bcmentioning

confidence: 99%

Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer

Liu

Deng

et al. 2021

Front. Oncol.

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The tumor microenvironment (TME) is a complex ecosystem comprised of cancer cells, stromal cells, and immune cells. Analysis of the composition of TME is essential to assess the prognosis of patients with breast cancer (BC) and the efficacy of different regimes. Treg plays a crucial role in the microenvironment of breast cancer subtypes, and its function contributes to the development and progression of BC by suppressing anti-tumor immunity directly or indirectly through multiple mechanisms. In addition, conventional treatments, such as anthracycline-based neoadjuvant chemotherapy, and neo-therapies, such as immune-checkpoint blockades, have a significant impact on the absence of Tregs in BC TME, thus gaining additional anti-tumor effect to some extent. Strikingly, Treg in BC TME revealed the predicted efficacy of some therapeutic strategies. All these results suggest that we can manipulate the abundance of Treg to achieve the ultimate effect of both conventional and novel treatments. In this review, we discuss new insights into the characteristics of Treg in BC TME, the impact of different regiments on Treg, and the possibilities of Treg as a predictive marker of efficacy for certain treatments.

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CD8+, CD4+ and FOXP3+ cell profiles and their change after neoadjuvant chemotherapy in patients with triple negative breast cancer

Cited by 2 publications

References 0 publications

Massage on the prevention of breast cancer through stress reduction and enhancing immune system

Massage on the prevention of breast cancer through stress reduction and enhancing immune system

Research Progress on the Role of Regulatory T Cell in Tumor Microenvironment in the Treatment of Breast Cancer

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