CD49d-expressing neutrophils differentiate atopic from nonatopic individuals

Sigua, Jerome A.; Buelow, Becky J.; Cheung, Dorothy; Buell, Erika; Hunter, Desire; Klancnik, Meribeth; Grayson, Mitchell H.

doi:10.1016/j.jaci.2013.09.035

Cited by 25 publications

(24 citation statements)

References 11 publications

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“…Heterogeneity of neutrophils is found at several levels: (i) nuclear appearance (band cells, mature and hypersegmented neutrophils); (ii) density (“low”-MDSCs versus “high” conventional density neutrophils [192]); (iii) NET-releasing versus non-NET-releasing neutrophils; and (iv) receptor expression profiles associated with distinct neutrophil subsets, which are summarized below: Olfactomedin 4-expressing neutrophils, associated with a NET-releasing neutrophil subtype [87]CD177 (NB1)-expressing neutrophils, associated with proteinase 3 and autoimmune diseases [193]CD16 bright CD62L dim for suppressive neutrophils in systemic inflammation [114]CD66b/CD33-expressing low-density neutrophils for neutrophilic MDSCs [192]CXCR4 + for aged/senescent neutrophils [194]CD63-expressing neutrophils in the airways of patients with CF [195]CD49d-expressing neutrophils in atopic individuals [196]VEGF-induced MMP-9 expressing “pro-angiogenic” neutrophils [187]Neutrophils expressing a T-cell receptor-associated variable immunoreceptor complex [197]ICAM-1/CD54-expressing neutrophils associated with systemic inflammation and reverse migration [23,198]N1/N2 tumor-associated neutrophils (TANs) in murine tumor models (antitumorigenic, proinflammatory N1 neutrophils; protumorigenic, immunosuppressive N2 neutrophils) [199]PMN-I (producing IL-12 and CCL3, inducing classically-activated macrophages) conferring protection against methicillin-resistant S . aureus (MRSA) infection and PMN-II (producing IL-10 and CCL2, inducing alternatively-activated macrophages) conferring susceptibility for MRSA infection [200]…”

Section: Neutrophil Heterogeneity and Plasticitymentioning

confidence: 99%

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

et al. 2015

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Neutrophils, the most abundant human immune cells, are rapidly recruited to sites of infection, where they fulfill their life-saving antimicrobial functions. While traditionally regarded as short-lived phagocytes, recent findings on long-term survival, neutrophil extracellular trap (NET) formation, heterogeneity and plasticity, suppressive functions, and tissue injury have expanded our understanding of their diverse role in infection and inflammation. This review summarises our current understanding of neutrophils in host-pathogen interactions and disease involvement, illustrating the versatility and plasticity of the neutrophil, moving between host defence, immune modulation, and tissue damage.

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Section: Neutrophil Heterogeneity and Plasticitymentioning

confidence: 99%

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

et al. 2015

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“…7,12 For instance, small fractions of human neutrophils have been reported to express selected molecules under both physiological and pathological conditions, including T-cell receptor-associated variable immunoreceptor, 14 olfactomedin 4, 12,15 neutrophil antigen B1 (NB1/CD177), 12,16,17 or CD49d. 18 Similarly, while senescent neutrophils express elevated levels of CXCR4, neutrophils undergoing reverse transendothelial cell migration express elevated levels of intercellular adhesion molecule-1 (ICAM-1) and low levels of CXCR1. 7,12 However, the biological and functional implications of these observations remain mostly unclear.…”

Section: Neutrophil Heterogeneitymentioning

confidence: 99%

Social networking of human neutrophils within the immune system

Scapini

Cassatella

2014

Blood

349

320

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It is now widely recognized that neutrophils are highly versatile and sophisticated cells that display de novo synthetic capacity and may greatly extend their lifespan. In addition, concepts such as “neutrophil heterogeneity” and “neutrophil plasticity” have started to emerge, implying that, under pathological conditions, neutrophils may differentiate into discrete subsets defined by distinct phenotypic and functional profiles. A number of studies have shown that neutrophils act as effectors in both innate and adaptive immunoregulatory networks. In fact, once recruited into inflamed tissues, neutrophils engage into complex bidirectional interactions with macrophages, natural killer, dendritic and mesenchymal stem cells, B and T lymphocytes, or platelets. As a result of this cross-talk, mediated either by contact-dependent mechanisms or cell-derived soluble factors, neutrophils and target cells reciprocally modulate their survival and activation status. Altogether, these novel aspects of neutrophil biology have shed new light not only on the potential complex roles that neutrophils play during inflammation and immune responses, but also in the pathogenesis of several inflammatory disorders including infection, autoimmunity, and cancer.

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“…IL-8 (CXCL8) is a potent neutrophil chemoattractant, suggesting a potential link between the neutrophilic response to viral or bacterial infection and subsequent development of aeroallergen sensitization. The plausibility of this link is supported by evidence that circulating neutrophils have distinct features in allergic individuals, 21 and neutrophils can promote the induction of FcεRI expression and allergy in animal models. 22 The association of atopy with progressive Th2 skewing to allergens was expected.…”

Section: Discussionmentioning

confidence: 97%

Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy

Gern

Calatroni

Jaffee

et al. 2017

Journal of Allergy and Clinical Immunology

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Background Disadvantaged urban children have high rates of allergic diseases and wheezing, which are diseases associated with Type 2-biased immunity. Objective To determine whether environmental exposures in early life influence cytokine responses which affect the development of recurrent wheezing illnesses and allergic sensitization. Methods A birth cohort of 560 urban families was recruited from neighborhoods with high rates of poverty, and 467 (83%) children were followed until 3 years of age. Cytokine responses were measured in blood cell samples obtained at birth (cord blood) and ages 1 and 3 years. Cytokine responses were examined in relation to personal characteristics and environmental exposures to allergens and endotoxin, and also to the development of allergic sensitization and recurrent wheeze assessed at age 3 years. Results Cytokine responses generally increased with age, but responses at birth were poorly predictive for those at ages 1 and 3 years. Exposure to certain allergens (cockroach, mouse, dust mite) was significantly associated with enhanced cytokine responses at age 3 years, including IFN-α and IL-10 responses to certain stimulants, and responses to phytohemagglutinin. Regarding the clinical outcomes, reduced LPS-induced IL-10 responses at birth was associated with recurrent wheeze. In contrast, reduced RSV-induced IL-8 responses, and increased CpG-induced IL-12p40 and allergen-induced IL-4 responses were associated with atopy. Conclusions These findings suggest that diverse biologic exposures, including allergens and endotoxin, in urban homes stimulate the development of cytokine responses in early life, and that cytokine responses to specific microbial and viral stimuli are associated with the development of allergic sensitization and recurrent wheeze.

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CD49d-expressing neutrophils differentiate atopic from nonatopic individuals

Cited by 25 publications

References 11 publications

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Social networking of human neutrophils within the immune system

Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy

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