Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

Krüger, Philipp; Saffarzadeh, Mona; Weber, Alexander N.R.; Rieber, Nikolaus; Radsak, Markus P.; Bernuth, Horst von; Benarafa, Charaf; Roos, Dirk; Skokowa, Julia; Hartl, Dominik

doi:10.1371/journal.ppat.1004651

Cited by 537 publications

(519 citation statements)

References 218 publications

(226 reference statements)

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“…39,40 Below we discuss the most recent studies describing neutrophil heterogeneity under homeostatic and disease conditions (Table 1). Abluminal to luminal transmigration Neutrophil activation by cues derived from sites of inflammation results in exposure of distinct surface markers or de novo synthesis of cytokines, characteristics that are both commonly used to define neutrophil subsets.…”

Section: Neutrophil Heterogeneitymentioning

confidence: 99%

Neutrophil heterogeneity: implications for homeostasis and pathogenesis

Silvestre-Roig

Hidalgo

Soehnlein

2016

Blood

346

305

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Neutrophils are polymorphonuclear leukocytes of the phagocytic system that act as first line of host defense against invading pathogens but are also important mediators of inflammation-induced injury. In contrast to other members of the innate immune system, neutrophils are classically considered a homogenous population of terminally differentiated cells with a well-defined and highly conserved function. Indeed, their short lifespan, the absent proliferative capacity, their limited ability to produce large amounts of cytokines, and the failure to recirculate from the tissue to the bloodstream have sustained this idea. However, increasing evidence over the last decade has demonstrated an unexpected phenotypic heterogeneity and functional versatility of the neutrophil population. Far beyond their antimicrobial functions, neutrophils are emerging as decision-shapers during innate and adaptive immune responses. These emerging discoveries open a new door to understand the role of neutrophils during homeostatic but also pathogenic immune processes. Thus, this review details novel insights of neutrophil phenotypic and functional heterogeneity during homeostasis and disease.

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Section: Neutrophil Heterogeneitymentioning

confidence: 99%

Neutrophil heterogeneity: implications for homeostasis and pathogenesis

Silvestre-Roig

Hidalgo

Soehnlein

2016

Blood

346

305

View full text Add to dashboard Cite

show abstract

“…Indirect defense mechanisms include the secretion of inflammation-amplifying cytokines and chemokines. Recent findings revealed that neutrophils also act as a communication interface that helps coordinate tissue regeneration and activation of adaptive responses (1,2). The high damaging potential of neutrophils is kept under control mainly by a limited lifespan (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection

Ebner

Sedlyarov

Tasciyan

et al. 2017

Journal of Clinical Investigation

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“…1,2 Neutrophils are continuously recruited to the oral mucosae 3 and are important for immune defense and tissue homeostasis in the oral cavity, as illustrated by neutropenia and functional neutrophil deficiencies that are associated with gingivitis, periodontitis, and ulcerations. 4,5 Indeed, oral ulcers are a characteristic feature of the periods of neutrophil nadirs in cyclic neutropenia.…”

Section: Introductionmentioning

confidence: 99%