CD4+ T-Lymphocytes cell counts in adults with human immunodeficiency virus infection at the medical department of a tertiary health institution in Nigeria

Abstract

Objectives: To evaluate the CD4ϩ cell counts in adults with human immunodefi ciency virus (HIV) infections presenting at the medical department of the Federal Medical Centre, Ido-Ekiti, Nigeria. Methods: This study was carried out at the medical department of the Federal Medical Centre (FMC), Ido-Ekiti, Nigeria, in the period July-December 2006. FMC, Ido, was recently upgraded to serve as the only center for HIV/AIDS referral, diagnosis and treatment in Ekiti State. The center offers free antiretroviral therapy. All patients with a diagnosis of HIV/AIDS, either diagnosed at the center or referred from other hospitals, admitted to the medical department within the study period had their blood sample taken for CD4 cell counts estimation at the fi rst visit to the center, as part of the routine workup to assess their disease status and need for antiretroviral therapy. Results: A total of 87 patients comprising of 54 (62.1%) females and 33 (37.9%) males had their CD4ϩ T-Lymphocytes cell counts evaluated within their fi rst week of presentation. The total mean age of the population studied was 33.17 Ϯ 7.01 years. The mean age of the females was 31 Ϯ 5.6 years, while that of the males was 36.5 Ϯ 8.2 years. The difference between the mean ages of females and males was statistically signifi cant (P ϭ 0.0004). The female: male ratio was 1.6:1. Out of the 87 patients, 30 were referrals from other hospitals within the state.

Virologic And Immunologic Outcome Of Treatment Of Hiv Infectionwith A Herbal Concoction, Α-Zam, Among Clients Seeking Herbal Remedy In Nigeria

“…Contrary to expectation and earlier studies that many HIV patients presented late or at advance state, less (24 patients) were seen in this study (Ajayi et al 2009). The advanced stage of HIV infection manifested in patients at WHO staging III and IV with pre-treatment average CD4 count of 247 cell/µL and 158 cell/µL respectively.…”

Usefulness of Certain Clinical and Laboratory Parameters in Predicting Presence of HIV Infection in Adult HIV/AIDS Positive Patients in a Limited Resource Setting

“…The difference is statistically significant (p<0.001). This finding is in keeping with reports of HIV incidence in Nigeria (Nwokedi et al, 2007;Ajayi et al, 2009Ajayi et al, , 2011 and outside the country (UAC., 2003; Kilaru et al, 2004). Persons in the age range 20-50 might be predisposed because they represent the reproductive and productive age group of any society and thus sexually active.…”

“…This is similar to that observed in previous Nigerian studies where females tend to have lower values than males (Ramana et al, 2010;Ajayi et al, 2009Ajayi et al, , 2011. The reasons for this might be that the females attain sexual maturity earlier than the males and are likely to engage in sexual practices earlier than the male counterpart.…”

Assessment of haematological parameters in HIV-infected and uninfected Rwandan women: a cross-sectional study

“…5 Although numerous complications occur in HIVinfected patients, 2 6 7 the most common haematological abnormalities are anaemia and neutropenia. 6 Anaemia and neutropenia are generally caused by inadequate blood cell production because of bone marrow suppression by HIV infection mediated by abnormal cytokine expression and alteration of the bone marrow microenvironment. 5 8 Anaemia in HIV-infected persons is associated with CD4 cell depletion and progression to AIDS 9 and is one of the strongest predictors of HIV mortality and poor responses to antiretroviral therapy (ART).…”