CD4⁺IL‐13⁺ cells in peripheral blood well correlates with the severity of atopic dermatitis in children

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting about 15% of children, with consequent costs and morbidity. The AD has its onset during the first

Case-Control Study of Eczema Associated with <i>IL13</i> Genetic Polymorphisms in Japanese Children

“…Skin lesions, especially acute skin lesions, and even unaffected skin from patients with atopic eczema were associated with an increased expression of IL-13 mRNA [3]. The percentage of IL-13-expressing CD4+ T cells in peripheral blood mononuclear cells in patients in the acute phase of atopic eczema was significantly higher than in control subjects; also, the percentage of CD4+ IL-13+ T cells in the patient group was significantly correlated with disease severity [4]. …”

Interferon gamma gene polymorphism as a marker of some allergic diseases (allergic skin diseases and allergic conjunctivitis) in a sample of Egyptian population

“…Interestingly, immunological response to allergens represents an important trigger for the increase of eosinophil counts in the peripheral blood and serum IgE level [52]. A Japanese study found that the eosinophil levels correlated with the allergic diseases, high blood eosinophil levels in atopic diseases [53]. They found that both the absolute eosinophil count and the IgE level showed significant increase with allergic diseases.…”

Impact of T‐cell receptor Vβ haplotypes on the development of dermatitis in DS‐Nh mice: synergistic production of interleukin‐13 caused by staphylococcal enterotoxin C and peptide glycans from Staphylococcus aureus

“…[17][18][19][20] Recently, a higher number of IL-13-expressing CD4-bearing T cells has been observed in the peripheral blood mononuclear cells of patients with AD compared to those of healthy individuals. 21 IL-13, which is a pivotal mediator of the Th2 immune response, 22 plays an important role in the recruitment of CD4-bearing T cells through activating keratinocytes in patients with acute AD. 23 Although IL-13 is a key cytokine in AD, mechanisms of IL-13 production in AD are not fully understood.…”

“…Furthermore, patients with acutephase AD possess a higher number of IL-13-expressing CD4-bearing T cells compared to healthy individuals. 21 More importantly, keratinocytes stimulated by IL-13 highly express CCL22, and cause infiltration of CD4-bearing T cells into lesions in skin, 23 providing a pathological marker for AD or AD-like dermatitis. 3,18 Furthermore, IL-13 induced collagen protein as well as mRNA in a dose-dependent manner, 38 and higher levels of collagen were an all too common clinical feature in untreated AD patients.…”