CD4-Mediated Anchoring of the Seminal Antigen gp17 onto the Spermatozoon Surface

Bergamo, Paolo; Balestrieri, Marco; Cammarota, G; Guardiola, John; Abrescia, Paolo

doi:10.1016/s0198-8859(97)00213-9

Cited by 28 publications

(22 citation statements)

References 38 publications

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“…In another respect, Bergamo et al reported that human PIP/gp17 also interacts with the spermatozoa cell surface via CD4, which is speculated to be related with capacitation ability. 19) Moreover, mouse seminal vesicle autoantigen (SVA), another member of the PIP gene family, is abundant in seminal plasma. This SVA exerts an inhibitory effect on spermatozoa mobility via interaction with cell membrane phospholipids.…”

Section: Discussionmentioning

confidence: 99%

Expression of the prolactin‐indudble protein (PIP/GCDFP15) gene in benign epithelium and adenocarcinoma of the prostate

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Expression of the prolactin‐indudble protein (PIP/GCDFP15) gene in benign epithelium and adenocarcinoma of the prostate

et al. 2004

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“…CD4 molecules were detected on mouse sperm heads by both immunofluorescence and western Blotting (189). Their presence was also suggested, indirectly, in a study using a semen protein (gp17) that binds to CD4 ϩ T cells and soluble recombinant CD4, as well as spermatozoa (38). However, the CD4 antigen has never been detected on the surface of human spermatozoa or on CD45…”

Section: Human Immunodeficiency Virus Typementioning

confidence: 98%

Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Dejucq

Jégou

2001

Microbiol Mol Biol Rev

287

220

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This review describes the various viruses identified in the semen and reproductive tracts of mammals (including humans), their distribution in tissues and fluids, their possible cell targets, and the functional consequences of their infectivity on the reproductive and endocrine systems. The consequences of these viral infections on the reproductive tract and semen can be extremely serious in terms of organ integrity, development of pathological and cancerous processes, and transmission of diseases. Furthermore, of essential importance is the fact that viral infection of the testicular cells may result not only in changes in testicular function, a serious risk for the fertility and general health of the individual (such as a fall in testosteronemia leading to cachexia), but also in the possible transmission of virus-induced mutations to subsequent generations. In addition to providing an exhaustive account of the data available in these domains, this review focuses attention on the fact that the interface between endocrinology and virology has so far been poorly explored, particularly when major health, social and economical problems are posed. Our conclusions highlight the research strategies that need to be developed. Progress in all these domains is essential for the development of new treatment strategies to eradicate viruses and to correct the virus-induced dysfunction of the endocrine system

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“…This can be confirmed by the hyper-representation of sperm capacitation and flagellum in the Low group. The overexpressed protein Prolactin-inducible Protein (PIP), an acrosomal protein that plays an important role in fertilization [82], was overexpressed in fertile men [83] and has been suggested as a potential fertility biomarker [40].…”

Section: Enriched Functions In the Low Sperm Dna Fragmentation Groupmentioning

confidence: 99%

Unraveling the sperm proteome and post-genomic pathways associated with sperm nuclear DNA fragmentation

Intasqui

Camargo

Giudice

et al. 2013

J Assist Reprod Genet

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Purpose Sperm DNA fragmentation has been suggested as a marker for infertility diagnosis and prognosis. Hence, understanding its impact on male physiology and post-genomic pathways would be clinically important. We performed the proteomics and functional enrichment analyses of viable spermatozoa from ejaculates with low and high sperm DNA fragmentation to identify protein expression and pathways altered in association with sperm DNA fragmentation. Methods Sperm DNA fragmentation using the Comet assay and the Komet 6.0.1 software was assessed in raw samples from 89 subjects from a human reproduction service. The Low and High sperm DNA fragmentation groups were formed according to the Olive Tail Moment variable. Spermatozoa proteins from these groups were pooled and analyzed by a shotgun proteomic approach (2D nanoUPLC-ESI-MS E ). Differentially expressed proteins were used for a functional enrichment study. Results Two hundred and fifty-seven proteins were identified or quantified in sperm from the Low and High sperm DNA fragmentation groups. Of these, seventy-one proteins were exclusively or overexpressed in the Low group, whereas twenty-three proteins were exclusively or overexpressed in the High group. One hundred and sixty-three proteins were conserved between these groups. We also functionally related the differentially expressed proteins in viable spermatozoa from the groups. Processes such as triacylglycerol metabolism, energy production, protein folding, response to unfolded proteins, and cellular detoxification were found to be altered in these cells. Conclusions Sperm DNA fragmentation is associated with differential protein expression in viable spermatozoa. These proteins may potentially be used as biomarkers for sperm DNA integrity.

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CD4-Mediated Anchoring of the Seminal Antigen gp17 onto the Spermatozoon Surface

Cited by 28 publications

References 38 publications

Expression of the prolactin‐indudble protein (PIP/GCDFP15) gene in benign epithelium and adenocarcinoma of the prostate

Expression of the prolactin‐indudble protein (PIP/GCDFP15) gene in benign epithelium and adenocarcinoma of the prostate

Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System

Unraveling the sperm proteome and post-genomic pathways associated with sperm nuclear DNA fragmentation

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