CD4 count is predictive of outcome in HIV-positive patients undergoing abdominal operations

The effect of HIV status on clinical outcomes of surgical sepsis in KwaZulu-Natal Province, South Africa

“…These findings differ from those of Caca la et al [2] Our findings were consistent with those in the litera ture. [16,17] Feng et al [18] used logistic regression to determine risk factors for the development of sepsis in surgical patients with HIV-infection, with and without sepsis. They reported that in HIV-infected patients who required surgery for malignancy or sepsis, those with a low CD4 count and with hypoalbuminaemia before surgery, had a higher probability of developing postoperative sepsis.…”

HIV Infection: Implications on Surgical Practice

“…The lower the CD4+ count, the higher the rates of post-operative infective complications, increased length of hospital stay, and mortality. While urgent surgical operations have been associated with increased morbidity and mortality, the overall postoperative mortality in HIV/AIDS is between 18% and 48% (Deneve et al, 2010). Patients undergoing oral or transoral surgery have a significantly increased incidence of wound sepsis when compared with those undergoing trans-dermal surgery (Reilly et al, 2009).…”

“…Studies have shown that CD4+ counts can be reliably used to predict the outcomes of patients with HIV/AIDS after surgical procedures (Deneve et al, 2010). HIV infection destroys the immune system: only 12% of patients have a CD4 cell count greater than 500 cells/μL, while 50% have a CD4 cell count below 200 cells/μL (Honda, 2006).…”

“…HIV/AIDS patients undergoing emergent surgery may also have lower CD4+ counts than those undergoing elective surgery (Deneve et al, 2010). The commonest complications after major abdominal surgery include wound infection, pneumonia, intra-abdominal abscesses, peritonitis, and sepsis (Rose et al, 1998).…”

Correlation analysis of compromised immune function with perioperative sepsis in HIV-positive patient

“…HIV selectively invades cells with CD4 receptor, so CD4 + T lymphocytes are main target cells. Once infected by HIV, the functions of CD4 + T lymphocytes are impaired or even destroyed largely, which is the leading cause of immunodeficiency [6,7]. When the number of CD4 + T lymphocytes are less than 200 cells/μl, patients may develop AIDS.…”