CD4+CD28null T lymphocyte frequency, a new marker of cardiovascular risk: relationship with polycystic ovary syndrome phenotypes

Moro, Francesca; Morciano, Andrea; Tropea, Anna; Sagnella, Francesca; Palla, Carola; Scarinci, Elisa; Cosentino, Nicola; Niccoli, Giampaolo; Liuzzo, Giovanna; Crea, Filippo; Lanzone, Antonio; Apa, Rosanna

doi:10.1016/j.fertnstert.2012.08.015

Cited by 18 publications

(20 citation statements)

References 39 publications

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“…In addition, the increased T cell proportion was mainly caused by the increased proportion of CD4+T cells. Previous studies have revealed that CD4+T cells are elevated in women with PCOS, 21,22 which was in accordance with our results. However, the changes in T lymphocyte subsets in patients with PCOS remain controversial at present.…”

Section: Discussionsupporting

confidence: 94%

<p>Peripheral Blood Inflammatory-Immune Cells as a Predictor of Infertility in Women with Polycystic Ovary Syndrome</p>

He¹,

Mao²,

Lei³

et al. 2020

JIR

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This study aimed to investigate the inflammatory-immune cells in the peripheral blood of women with polycystic ovary syndrome (PCOS) and assessed the potential correlation between inflammatory-immune cells and infertility in PCOS women. Materials and Methods: In this case-control study, the profiles of lymphocyte subsets were analyzed by flow cytometry. White blood cells (WBC), neutrophils (Neu), lymphocytes, Ferriman-Gallwey (F-G) score, testosterone, prolactin, follicle-stimulating hormone, luteinizing hormone, fasting blood glucose, and fasting plasma insulin were measured, together with body mass index. Association between inflammatory-immune cells and PCOS was evaluated. Moreover, inflammatory-immune cells of the PCOS women with infertility were evaluated, and the relative operating characteristic (ROC) curve and cutoff values were calculated. Results: The number of WBC, Neu, and lymphocytes was higher in PCOS women than controls (P<0.05). The percentages of total T lymphocytes, CD4+T, and NK were significantly increased in the PCOS group (P<0.001). The CD4/CD8 ratio was obviously elevated for increasing CD4+T (P<0.05). Consequently, T%, CD4+T%, and NK% were found to be the independent risk factors of PCOS by ROC curve and multivariate logistic regression analysis. Furthermore, only NK% was significantly higher in PCOS women with infertility than those who had PCOS without infertility (P<0.001). To diagnose infertility in PCOS, the cutoff value of NK% was calculated as 16.43%. Conclusion: These findings suggest that the pathogenesis of PCOS is related to immune cells including T, CD4+T, and NK cells. NK cells are likely to be a potential predictive factor for PCOS women with infertility.

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Section: Discussionsupporting

confidence: 94%

<p>Peripheral Blood Inflammatory-Immune Cells as a Predictor of Infertility in Women with Polycystic Ovary Syndrome</p>

He¹,

Mao²,

Lei³

et al. 2020

JIR

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“…1). Consistent with previous reports, there were no disturbances in the percentages of CD4 + T cells in PCOS patients with infertility 31 . Although the percentage of CD4 + T cells did not change in PCOS patients with infertility, both CD4 + and CD8 + T cells expressed significantly lower levels of CD69 in the PCOS group ( P < 0.01, Fig.…”

Section: Discussionsupporting

confidence: 92%

Detection of T lymphocyte subsets and related functional molecules in follicular fluid of patients with polycystic ovary syndrome

Peng

Feng

et al. 2019

Sci Rep

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Immune responses play an important role in the pathogenesis of polycystic ovary syndrome (PCOS). However, the characteristics of T lymphocyte subsets in PCOS remain insufficiently understood. In this study, lymphocytes of follicular fluid (FF) were obtained from oocyte retrieval before in-vitro fertilization (IVF) in infertile women with or without PCOS. The levels of cluster of differentiation 25 (CD25), CD69, programmed death 1 (PD-1), interferon-γ (IFN-γ), interleukin 17A (IL-17A) and IL-10 in T lymphocytes were determined by flow cytometry. Our results showed that the percentage of FF CD8 + T cells was significantly decreased in infertile patients with PCOS ( P < 0.05). Furthermore, the levels of CD69 and IFN-γ were significantly decreased and the level of PD-1 was increased in both CD4 + and CD8 + T cells from infertile patients with PCOS ( P < 0.05). Moreover, the expression of PD-1 on CD4 + or CD8 + T cells was positively correlated with the estradiol (E2) levels in the serum and reversely correlated with the expression of IFN-γ in CD4 + or CD8 + T cells in infertile patients with PCOS. These results suggested that T cell dysfunction may be involved in the pathogenesis of PCOS.

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“…Our group previously demonstrated the absence of differences in terms of total lymphocyte count and total CD4 þ T-cell frequency between women with PCOS and control women. 9 We further confirmed these results in a recent article of Moro et al 21 At present, insulin-sensitizing drugs, such as metformin, represent one of the most important line treatments for women with hyperinsulinemic PCOS. Metformin is able to produce favorable outcomes on the metabolic derangements in insulin-resistant normal weight and obese patients with PCOS.…”

Section: Introductionsupporting

confidence: 84%

Effects of Drospirenone–Ethinylestradiol and/or Metformin on CD4+CD28null T Lymphocytes Frequency in Women With Hyperinsulinemia Having Polycystic Ovary Syndrome: A Randomized Clinical Trial

et al. 2013

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CD4+CD28null T lymphocyte frequency, a new marker of cardiovascular risk: relationship with polycystic ovary syndrome phenotypes

Cited by 18 publications

References 39 publications

<p>Peripheral Blood Inflammatory-Immune Cells as a Predictor of Infertility in Women with Polycystic Ovary Syndrome</p>

<p>Peripheral Blood Inflammatory-Immune Cells as a Predictor of Infertility in Women with Polycystic Ovary Syndrome</p>

Detection of T lymphocyte subsets and related functional molecules in follicular fluid of patients with polycystic ovary syndrome

Effects of Drospirenone–Ethinylestradiol and/or Metformin on CD4+CD28null T Lymphocytes Frequency in Women With Hyperinsulinemia Having Polycystic Ovary Syndrome: A Randomized Clinical Trial

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