CD300c costimulates IgE-mediated basophil activation, and its expression is increased in patients with cow's milk allergy

Zenarruzabeitia, Olatz; Vitallé, Joana; Terrén, Íñigo; Orrantia, Ane; Astigarraga, Itziar; Dopazo, L González; González, Carlos Canseco; Santos-Díez, Laura; Tutau, Carlos; Gamboa, P. M.; Bilbao, Agurtzane; Borrego, Francisco

doi:10.1016/j.jaci.2018.05.022

Cited by 16 publications

(32 citation statements)

References 63 publications

(104 reference statements)

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“…It has been reported that CD300c has effects on other types of immune cells ( 21 – 30 ). Crosslinking of CD300c on NK cells by its antibody induce cytokine secretion and degranulation ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

“…Crosslinking of CD300c on NK cells by its antibody induce cytokine secretion and degranulation ( 23 ). CD300c is also involved in the modulation of IgE-mediated basophil activation ( 30 ). mCD300c2 non-covalently associates with the signaling adaptor DAP10 in macrophages and B cells ( 27 , 34 ).…”

Section: Discussionmentioning

confidence: 99%

“…Human CD300c (hCD300c), also known as CMRF-35A or CMRF-35, was originally isolated from human leukocytes ( 18 – 20 ). It has been reported that CD300c has effects on NK cells, monocytes, macrophages, B cells, DCs and basophils ( 21 – 30 ). CD300c can bind to plasma membrane lipids phosphatidylethanolamine (PE) and phosphatidylserine (PS) ( 23 , 30 , 31 ).…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that CD300c has effects on NK cells, monocytes, macrophages, B cells, DCs and basophils ( 21 – 30 ). CD300c can bind to plasma membrane lipids phosphatidylethanolamine (PE) and phosphatidylserine (PS) ( 23 , 30 , 31 ). However, the functional significance of CD300c on T cells has not been characterized.…”

Section: Introductionmentioning

confidence: 99%

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A CD300c-Fc Fusion Protein Inhibits T Cell Immunity

Cui

Lin

et al. 2018

Front. Immunol.

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T cell responses are fine-tuned by co-stimulatory and co-inhibitory molecules. Among the T cell regulators, the B7 family members are of central importance. The recent success in targeting the B7 family molecules for the treatment of immune-related diseases has attracted intense interest in identifying additional B7-related molecules. In this study, we describe CD300c as a novel T cell co-inhibitory molecule that shares significant sequence homology with existing B7 family members. CD300c protein is expressed on professional antigen-presenting cells (APC), including B cells, monocytes, macrophages, and dendritic cells (DCs). The putative CD300c counter-receptor is expressed on CD4 and CD8 T cells, and the expression levels are upregulated upon activation. Soluble human and mouse CD300c-Fc fusion proteins significantly inhibit the proliferation, activation, and cytokine production by CD4 and CD8 T cells in vitro. Administration of CD300c-Fc protein attenuates graft-vs.-host disease (GVHD) in mice. Our results suggest that therapeutic interaction with the CD300c inhibitory pathway may represent a new strategy to modulate T cell-mediated immunity for the treatment of GVHD and autoimmune disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A CD300c-Fc Fusion Protein Inhibits T Cell Immunity

Cui

Lin

et al. 2018

Front. Immunol.

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“…Over the past few years, several publications have highlighted the important role the CD300 family of receptors has in complex biological processes such as phagocytosis, proliferation, and cytokine production [7, 12,13,17,24,25,30,31,39,40], and in a variety of diseases, including autoimmune disorders, allergic and inflammatory diseases, hematological malignancies, sepsis, etc. [7,12,17,19,21,33,[41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58]. Here, we review several aspects involving the CD300 molecules and viral infections, including how viruses use these receptors to interact with and enter cells or to escape from the attack of the immune system.…”

Section: Introductionmentioning

confidence: 99%

CD300 receptor family in viral infections

et al. 2018

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The CD300 molecules constitute an evolutionarily significant family of receptors that are expressed on myeloid and lymphoid cells, but also on other cell types, such as tuft cells. Many of the CD300 receptors have been shown to recognize lipids, e.g. phosphatidylserine and phosphatidylethanolamine. Over the past couple of years, accumulating evidence has shown that this family of receptors is involved in the pathogenesis of many diseases. Specifically, CD300 molecules participate in the mechanisms that viruses employ to develop immune evasion strategies and to infect host cells. The participation of CD300 molecules in viral infection includes both lipid dependent and independent mechanisms, as for example in infections with dengue virus (DENV) and murine norovirus (MNV), respectively. CD300 receptors are also involved in viral escape mechanisms, for instance inhibiting NK cell‐mediated cytotoxicity against infected cells. Moreover, it is becoming increasingly recognized that the expression of CD300 receptors is altered during viral diseases. Here, we review the involvement of human and murine CD300 molecules in viral binding and entry and in cellular responses to viruses, which highlights the potential of CD300 molecules in the search of new biomarkers for various stages of infection and therapeutic targets for the treatment of viral infections.

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