CD3+, CD8+, CD4+ and FOXP3+ T Cells in the Immune Microenvironment of Small Bowel Neuroendocrine Tumors

Hiltunen, Niko; Väyrynen, Juha P.; Böhm, Jan; Helminen, Olli

doi:10.3390/diseases9020042

Cited by 5 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CD3 and CD8 are the most common biomarkers for total T lymphocytes and cytotoxic T cells, respectively (Hiltunen et al, 2021). Foxp3 is a transcription factor that is an important marker, which participates in the differentiation and functioning of Treg (Diana et al, 2016; Hayashi et al, 2022; Yu et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Influence of PD‐1/PD‐L1 on immune microenvironment in oral leukoplakia and oral squamous cell carcinoma

Wang

Shi

et al. 2022

Oral Diseases

View full text Add to dashboard Cite

ObjectiveTo evaluate the relation between the expression of PD‐1, PD‐L1, CD3, CD8, Foxp3 and clinicopathological features in patients with oral leukoplakia (OLK) and oral squamous cell carcinomas (OSCC) as well as the malignant outcome in OLK patients, and to study the effect of PD‐1 and PD‐L1 on immune microenvironment in the progression of oral carcinogenesis.MethodsWe evaluated the expression of PD‐1/PD‐L1 and composition of CD3+, CD8+and Foxp3+ T lymphocytes in OLK and OSCC samples by immunohistochemical (IHC) staining and analyzed their relation with clinical information and malignant transformation in OLK patients.ResultsIHC staining demonstrated that the expression of PD‐1 was significantly increased in the high‐grade OLK group than in the low‐grade OLK group, while PD‐L1 was detected mainly in OSCC. The expression of CD3, CD8, and Foxp3 was found higher in the high‐grade OLK group than in the low‐grade OLK group, and the Foxp3+ cells were found more in the OSCC group than in the high‐grade OLK group. PD‐1 was significantly correlated with CD3 (p < 0.05, R = 0.52), CD8 (p < 0.05, R = 0.46), and Foxp3 (p < 0.05, R = 0.46), and the low PD‐1‐expression group showed a better malignant‐free survival than high PD‐1 expression group in the OLK (p < 0.05).ConclusionThe PD‐1/PD‐L1 may induce immune suppression in OLK and accelerate the progress of malignant transformation.

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of PD‐1/PD‐L1 on immune microenvironment in oral leukoplakia and oral squamous cell carcinoma

Wang

Shi

et al. 2022

Oral Diseases

View full text Add to dashboard Cite

show abstract

“…The initial cohort and data collection have been previously described [ 24 ]. The original data was collected between February 1, 2019 and May 1, 2019.…”

Section: Methodsmentioning

confidence: 99%

Toll-like receptors 1–9 in small bowel neuroendocrine tumors–Clinical significance and prognosis

Hiltunen,

Kemi,

Väyrynen

et al. 2024

PLoS ONE

Self Cite

View full text Add to dashboard Cite

Toll-like receptors (TLRs) are pattern recognition receptors of the innate immunity. TLRs are known to mediate both antitumor effects and tumorigenesis. TLRs are abundant in many cancers, but their expression in small bowel neuroendocrine tumors (SB-NETs) is unknown. We aimed to characterize the expression of TLRs 1–9 in SB-NETs and lymph node metastases and evaluate their prognostic relevance. The present study included 125 patients with SB-NETs, of whom 95 had lymph node metastases, from two Finnish hospitals. Tissue samples were stained immunohistochemically for TLR expression, assessed based on cytoplasmic and nucleic staining intensity and percentage of positively stained cells. Statistical methods for survival analysis included Kaplan-Meier method and Cox regression adjusted for confounding factors. Disease-specific survival (DSS) was the primary outcome. TLRs 1–2 and 4–9 were expressed in SB-NETs and lymph node metastases. TLR3 showed no positive staining. In primary SB-NETs, TLRs 1–9 were not associated with survival. For lymph node metastases, high cytoplasmic TLR7 intensity associated with worse DSS compared to low cytoplasmic intensity (26.4% vs. 84.9%, p = 0.028). Adjusted mortality hazard (HR) was 3.90 (95% CI 1.07–14.3). The expression of TLRs 1–6 and 8–9 in lymph node metastases were not associated with survival. SB-NETs and their lymph node metastases express cytoplasmic TLR 1–2 and 4–9 and nucleic TLR5. High TLR7 expression in SB-NET lymph node metastases was associated with worse prognosis. The current research has future perspective, as it can help create base for clinical drug trials to target specific TLRs with agonists or antagonists to treat neuroendocrine tumors.

show abstract

Tumour immune microenvironment in resected thymic carcinomas as a predictor of clinical outcome

et al. 2022

View full text Add to dashboard Cite

CD3+, CD8+, CD4+ and FOXP3+ T Cells in the Immune Microenvironment of Small Bowel Neuroendocrine Tumors

Cited by 5 publications

References 33 publications

Influence of PD‐1/PD‐L1 on immune microenvironment in oral leukoplakia and oral squamous cell carcinoma

Influence of PD‐1/PD‐L1 on immune microenvironment in oral leukoplakia and oral squamous cell carcinoma

Toll-like receptors 1–9 in small bowel neuroendocrine tumors–Clinical significance and prognosis

Tumour immune microenvironment in resected thymic carcinomas as a predictor of clinical outcome

Contact Info

Product

Resources

About