CD25+CD4+ Regulatory T Cells and Memory T Cells Prevent Lymphopenia-Induced Proliferation of Naive T Cells in Transient States of Lymphopenia

Bourgeois, Christine; Stockinger, Brigitta

doi:10.4049/jimmunol.177.7.4558

Cited by 47 publications

(52 citation statements)

References 71 publications

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“…It has been postulated that they are neutral 'bystanders' , meaning that they do not contribute nor impair immune responses. It has also been suggested that they may down-regulate the immune response by suppressing the proliferation of naive T cells through a mechanism that mirrors the suppression of naive T cells by memory T cells [61]. Alternatively, it has also been reported that antigen-independent proliferating CD8 + T cells enhance the immune response through production of IFN-γ and other mediators of effector functions [19,51,62].…”

Section: Cd8mentioning

confidence: 99%

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Influenza infection results in local expansion of memory CD8+ T cells with antigen non-specific phenotype and function

Sckisel

Tietze

Zamora

et al. 2013

Clinical and Experimental Immunology

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Summary Primary viral infections induce activation of CD8+ T cells responsible for effective resistance. We sought to characterize the nature of the CD8 + T cell expansion observed after primary viral infection with influenza. Infection of naive mice with different strains of influenza resulted in the rapid expansion of memory CD8 + T cells exhibiting a unique bystander phenotype with significant up-regulation of natural killer group 2D (NKG2D), but not CD25, on the CD44 high CD8+ T cells, suggesting an antigen non-specific phenotype. We further confirmed the non-specificity of this phenotype on ovalbuminspecific (OT-I) CD8 + T cells, which are not specific to influenza. These nonspecific CD8 + T cells also displayed increased lytic capabilities and were observed primarily in the lung. Thus, influenza infection was shown to induce a rapid, antigen non-specific memory T cell expansion which is restricted to the specific site of inflammation. In contrast, CD8 + T cells of a similar phenotype could be observed in other organs following administration of systemic agonistic anti-CD40 and interleukin-2 immunotherapy, demonstrating that bystander expansion in multiple sites is possible depending on whether the nature of activation is either acute or systemic. Finally, intranasal blockade of NKG2D resulted in a significant increase in viral replication early during the course of infection, suggesting that NKG2D is a critical mediator of anti-influenza responses prior to the initiation of adaptive immunity. These results characterize further the local bystander expansion of tissue-resident, memory CD8 + T cells which, due to their early induction, may play an important NKG2D-mediated, antigen non-specific role during the early stages of viral infection.

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Section: Cd8mentioning

confidence: 99%

“…Quantification of A/PR8 influenza virus using real-time PCR was performed as described previously [61]. Briefly, total RNA was extracted from aliquots of lung homogenates using a QIAamp Viral RNA Kit (Qiagen).…”

Section: Viral Titre Determination By Quantitative Reverse Transcriptmentioning

confidence: 99%

Influenza infection results in local expansion of memory CD8+ T cells with antigen non-specific phenotype and function

Sckisel

Tietze

Zamora

et al. 2013

Clinical and Experimental Immunology

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“…Although previous reports show absence of CD4 1 T cells in early reconstitution after CB HSCT, 54 others suggest the presence of residual donor T cells including Treg cells after HSCT depending on the conditioning used. [56][57][58] These studies highlighted the survival of Treg cells and the possibility that these cells create a tolerant environment that may have an impact on NK cells which is crucial for early responses after HSCT.…”

Section: Interaction Between Nk Cells and Treg Cells In Hematopoieticmentioning

confidence: 99%

Interaction between natural killer cells and regulatory T cells: perspectives for immunotherapy

2013

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Regulatory T (Treg) cells and natural killer (NK) cells are key players in the immune system. The interaction between these two cell types has been reported to be beneficial in healthy conditions such as pregnancy. However, in the case of certain pathologies such as autoimmune diseases and cancer this interaction can become detrimental, as Treg cells have been described to suppress NK cells and in particular to impair NK cell effector functions. This review aims to discuss the recent information on the interaction between Treg cells and NK cells under healthy and pathologic conditions, to describe the specific conditions in which this interaction takes place, the effect of Treg cells on hematopoietic stem cell differentiation and the consequences of this interaction on the optimization of immunotherapeutic protocols.

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“…However, these data gathered with various experimental methods are difficult to combine into a single model accounting for the quantitative aspects of cell dynamics. In addition, the temporal parameters of the population dynamics of T cells in response to a short lymphopenia have only partially been established (22)(23)(24)(25)(26). This leaves us with a puzzling, complex, and incomplete view of thymocyte and peripheral T cell dynamics.…”

mentioning

confidence: 99%

Comprehensive Assessment and Mathematical Modeling of T Cell Population Dynamics and Homeostasis

Thomas‐Vaslin

Altes

Boer

et al. 2008

The Journal of Immunology

107

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Our current view of T cell differentiation and population dynamics is assembled from pieces of data obtained from separate experimental systems and is thus patchy. We reassessed homeostasis and dynamics of T cells 1) by generating a mathematical model describing the spatiotemporal features of T cell differentiation, and 2) by fitting this model to experimental data generated by disturbing T cell differentiation through transient depletion of dividing T cells in mice. This specific depletion was obtained by administration of ganciclovir to mice expressing the conditional thymidine kinase suicide gene in T cells. With this experimental approach, we could derive quantitative parameters describing the cell fluxes, residence times, and rates of import, export, proliferation, and death across cell compartments for thymocytes and recent thymic emigrants (RTEs). Among other parameters, we show that 93% of thymocytes produced before single-positive stages are eliminated through the selection process. Then, a postselection peripheral expansion of naive T cells contributes three times more to naive T cell production than the thymus, with half of the naive T cells consisting of dividing RTEs. Altogether, this work provides a quantitative population dynamical framework of thymocyte development, RTEs, and naive T cells.

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CD25+CD4+ Regulatory T Cells and Memory T Cells Prevent Lymphopenia-Induced Proliferation of Naive T Cells in Transient States of Lymphopenia

Cited by 47 publications

References 71 publications

Influenza infection results in local expansion of memory CD8+ T cells with antigen non-specific phenotype and function

Influenza infection results in local expansion of memory CD8+ T cells with antigen non-specific phenotype and function

Interaction between natural killer cells and regulatory T cells: perspectives for immunotherapy

Comprehensive Assessment and Mathematical Modeling of T Cell Population Dynamics and Homeostasis

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