CD20+ Tumor Infiltrating B Lymphocyte in Oral Squamous Cell Carcinoma: Correlation with Clinicopathologic Characteristics and Heat Shock Protein 70 Expression

Taghavi, Nasim; Mohsenifar, Zhaleh; Baghban, Alireza Akbarzadeh; Arjomandkhah, Alireza

doi:10.1155/2018/4810751

Cited by 19 publications

(20 citation statements)

References 34 publications

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“…Potential clinical roles of several HSPs in oral cancers have been reported. For example: HSPA4 is considered as a prognostic indicator in OSCC 11 . HSP90AA1 and HSPB1 are prognostic biomarker and therapeutic target in OSCC 12,13 .…”

Section: Introductionmentioning

confidence: 99%

HSPD1 repressed E-cadherin expression to promote cell invasion and migration for poor prognosis in oral squamous cell carcinoma

Kang

Shu

Chao

et al. 2019

Sci Rep

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Buccal mucosa squamous cell carcinoma (BMSCC) is one of major subsites of oral cancer and is associated with a high rate of metastasis and poor prognosis. Heat shock proteins (HSPs) act as potential prognostic biomarkers in many cancer types. However, the role of HSPD1 in oral cancer, especially in BMSCC, is still unknown. Through data analysis with The Cancer Genome Atlas (TCGA), we found the association of HSPD1 gene expression with tumorigenesis and poor prognosis in oral cancer patients. Our cohort study showed that higher HSPD1 protein level was associated with tumorigenesis and poor prognosis in BMSCC patients with lymph node invasion, suggesting that HSPD1 may be involved in tumor metastasis. Moreover, knockdown of HSPD1 induced E-cadherin expression and decreased the migration and invasion of BMSCC cells. In contrast, ectopic expression of HSPD1 diminished E-cadherin expression and promoted the migration/invasion of BMSCC cells. Further, HSPD1 regulated RelA activation to repress E-cadherin expression, enhancing the migration and invasion of BMSCC cells. Furthermore, HSPD1 protein level was inversely correlated with E-cadherin protein level in tumor tissues and co-expression of high HSPD1/low E-cadherin showed a significant association with poor prognosis in BMSCC patients. Taken together, HSPD1 might repress E-cadherin expression and promote metastatic characters of BMSCC cells for poor prognosis of BMSCC patients.

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Section: Introductionmentioning

confidence: 99%

HSPD1 repressed E-cadherin expression to promote cell invasion and migration for poor prognosis in oral squamous cell carcinoma

Kang

Shu

Chao

et al. 2019

Sci Rep

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“…Most studies were focused on the association of HSP70 and HSP27 with oral cancer. Of 26 eligible studies, there were 13 studies were on HSP70 protein expression and oral cancer [ 21 – 27 , 33 , 34 , 37 , 41 – 43 ] (315 patients), 9 on HSP27 [ 12 , 23 , 28 , 29 , 35 , 36 , 38 – 40 ] (111 patients), 4 on HSP90 [ 23 , 25 , 32 , 44 ] (90 patients), 3 on HSP60 [ 23 , 30 , 31 ] (60 patients), and 2 on HSP105 [ 12 , 45 ] (126 patients). Two published studies were conducted for the prognosis value of HSP70 [ 24 , 43 ] and 3 for HSP27 [ 35 , 39 , 40 ] protein expression in oral cancer.…”

Section: Resultsmentioning

confidence: 99%

“…For example, study of Zheng et al [ 37 ] demonstrated patients with HSP70 overexpression had a more advanced stage of oral cancer, but Taghavi’ study found HSP70 overexpression was a protective factor for advanced stage. [ 34 ] At the same time, opposite results were also detected for the differentiation or oral cancer, [ 33 , 34 ] in which the 2 studies were all performed in OSCC patients. So we might confirm that HSP70 had a closely association with risk or prognosis of oral cancer, but the published studies could not provide definite results because of fewer studies and opposite results.…”

Section: Discussionmentioning

confidence: 99%

Prognosis and predictive value of heat-shock proteins expression in oral cancer

Lü¹,

Yong-wu²,

Gan³

et al. 2021

Medicine

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Background: Heat-shock proteins (HSP) is a key chaperone protein which maintains intracellular proteostasis and is expressed on the surface of solid and hematological malignancies. Several studies have reported paradoxical evidence of the association between HSP expression and prognosis of oral cancer. To address the discrepancy, we carried out the meta-analysis to assess the role of HSP such as: HSP70, HSP90, HSP27, HSP60, and HSP105 in susceptibility, progression, and prognosis of oral cancer. Materials and methods: We retrieved the PubMed, Embase, Web of science, China National Knowledge Infrastructure (CNKI), and Wanfang databases to acquire the eligible studies which were associated with HSP70, HSP90, HSP27, HSP60, and HSP105 protein expression and oral cancer. We applied hazard ratio (HR) and its 95% confidence interval (95% CI) to assess the value of HSP protein expression in overall survival of oral cancer; odds ratio (OR) and its 95% CI were used to evaluate the association of risk and clinical features of oral cancer. Funnel plot, Begg test, and Egger line regression test were utilized to observe publication bias among studies. All statistical analysis was performed with Stata 14.0 software (Stata Corporation, College Station, TX). Results: A total of 26 studies were included in the present meta-analysis. On based of the results, HSP70 and HSP27 had no significant association with progression of oral cancer. However, the pooled HR and 95% CI revealed a significant well effects of HSP70 and HSP27 expression on survival of oral cancer. Moreover, the susceptibility of oral cancer was significantly associated with HSP70 and HSP60 overexpression. Conclusion: HSP70 and HSP27 protein overexpression might be valuable biomarkers for the prognosis of oral cancer. And HSP70 and HSP60 might have potential predictive effects on the risk of oral cancer.

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“…B cells consistently represent a substantial cellular component in tumor microenvironment, who exert their functions through antibody production, antigen presentation, and immune regulation. 8,9 Some investigations have indicated that tumorinfiltrating B cells were associated with favorable prognosis in human solid tumors, such as breast cancer, 10 oral cancer, 11 non-small cell lung cancer (NSCLC), 12,13 ovarian cancer, 14 and melanoma. 15 The underlying mechanisms include inducing tumor cell apoptosis through antibody-dependent cell-mediated cytotoxicity and serving as an antigen presenting cells to activate effector cells.…”

Section: Introductionmentioning

confidence: 99%

Landscape of infiltrating B cells and their clinical significance in human hepatocellular carcinoma

et al. 2019

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As a major cellular component in tumor microenvironment, the distribution, frequency, and prognostic significance of infiltrating B cell subsets in hepatocellular carcinoma (HCC) remain controversial. Using tyramide signal amplification (TSA) based fluorescent multiplexed immunohistochemistry in situ, we evaluated the distribution and frequency of B cell subsets in two independent HCC cohorts (n = 619). The results were further confirmed by flow cytometry. Correlations of B cell subsets with clinicopathologic features and patient prognosis were analyzed. Five B cell subsets were defined by multiplexed immunohistochemistry and each subset was clearly separated by t-SNE dimension reduction analysis. Notably, the densities of all B cell subsets were significantly decreased in the tumor. The frequency of plasma cells within B cells was most abundant in the tumor. In training cohort (n = 258), high densities of tumor-infiltrating CD20 + B cells, naive B cells, IgM + memory B cells, CD27 − isotypeswitched memory B cells, and plasma cells were associated with superior survival. Multivariate analysis further identified CD20 + B cells, naive B cells, and CD27 − isotype-switched memory B cells as independent prognosticators for survival. Unsupervised cluster analysis confirmed increased B cell subsets harbored superior survival. In addition, high density of B cells was correlated with smaller tumor size and well differentiation. The results were validated in the independent cohort of 361 HCC patients. Intratumor infiltration of B cells is significantly impaired during HCC progression. High densities of tumor-infiltrating B cells imply a better clinical outcome. Therapies designed to target B cells may be a novel strategy in HCC.

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CD20+ Tumor Infiltrating B Lymphocyte in Oral Squamous Cell Carcinoma: Correlation with Clinicopathologic Characteristics and Heat Shock Protein 70 Expression

Cited by 19 publications

References 34 publications

HSPD1 repressed E-cadherin expression to promote cell invasion and migration for poor prognosis in oral squamous cell carcinoma

HSPD1 repressed E-cadherin expression to promote cell invasion and migration for poor prognosis in oral squamous cell carcinoma

Prognosis and predictive value of heat-shock proteins expression in oral cancer

Landscape of infiltrating B cells and their clinical significance in human hepatocellular carcinoma

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