Prognosis and predictive value of heat-shock proteins expression in oral cancer

Abstract

Background: Heat-shock proteins (HSP) is a key chaperone protein which maintains intracellular proteostasis and is expressed on the surface of solid and hematological malignancies. Several studies have reported paradoxical evidence of the association between HSP expression and prognosis of oral cancer. To address the discrepancy, we carried out the meta-analysis to assess the role of HSP such as: HSP70, HSP90, HSP27, HSP60, and HSP105 in susceptibility, progression, and prognosis of oral cancer. Materials and methods: We retrieved the PubMed, Embase, Web of science, China National Knowledge Infrastructure (CNKI), and Wanfang databases to acquire the eligible studies which were associated with HSP70, HSP90, HSP27, HSP60, and HSP105 protein expression and oral cancer. We applied hazard ratio (HR) and its 95% confidence interval (95% CI) to assess the value of HSP protein expression in overall survival of oral cancer; odds ratio (OR) and its 95% CI were used to evaluate the association of risk and clinical features of oral cancer. Funnel plot, Begg test, and Egger line regression test were utilized to observe publication bias among studies. All statistical analysis was performed with Stata 14.0 software (Stata Corporation, College Station, TX). Results: A total of 26 studies were included in the present meta-analysis. On based of the results, HSP70 and HSP27 had no significant association with progression of oral cancer. However, the pooled HR and 95% CI revealed a significant well effects of HSP70 and HSP27 expression on survival of oral cancer. Moreover, the susceptibility of oral cancer was significantly associated with HSP70 and HSP60 overexpression. Conclusion: HSP70 and HSP27 protein overexpression might be valuable biomarkers for the prognosis of oral cancer. And HSP70 and HSP60 might have potential predictive effects on the risk of oral cancer.

Prognostic Gene Signature for Squamous Cell Carcinoma with a Higher Risk for Treatment Failure and Accelerated MEK-ERK Pathway Activity

“…Finally, BZW1 and CAMK2A were not reported in SCC tumors yet; however, they were identified as prognostic markers in non-SCC tumors [46][47][48][49]. In the past, several prognostic biomarkers or gene sets have been published of which some have been confirmed by systematic reviews and meta-analyses for HNSCC more recently [50][51][52]. It is worth noting that none of them are included in our list of survival-related candidate genes and consequently are not part of the prognostic 18 gene signature for risk prediction.…”

Protein Profile of Human Saliva as a Predictive and Prognostic Tool for OSCC in Tamol Chewer’s Population in Assam

“…On the other hand, HPSs, also known as stress protein is expressed in a wide variety of physiological and environmental stress. Mammalian HSPs are classified into 5 categories according to their molecular weight (Lu et al, 2021). The ATP-dependent chaperone families HSP70 and HSP27 are the most studied protein because of their involvement in oral cancer (Lu et al, 2021) and are frequently related to the progression of tongue squamous cell carcinoma and also serve as an important biomarker (Wan et al, 2009).…”

Impact and future of telemedicine amidst the COVID-19 pandemic: a systematic review of the state-of-the-art in Latin America

“…To uncover the objectives of this study as noted in the rationale of this study (see Introduction section); this work performed a systematic review of the relevant literature within the telemedicine, COVID-19, and LATAM context. The study criteria was grounded on a set of theoretic factors that we have chosen based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology [29][30][31][32] . The PRISMA approach for evaluation of the literature was chosen in order to allow the authors to determine the key factors and success rate reported across the LAT-AM region.…”

“…The extracted papers from the databases were selected based on the following criteria [29][30][31][32] (see Figure 1): 1) Description or title of the paper is related to telemedicine, COVID-19, or LATAM? 2) If the full text is available?…”